| Entry |
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| Gene name |
Pklr, Pk, Pk-, Pk-1, Pk1, R-, R-PK
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| Definition |
(RefSeq) pyruvate kinase liver and red blood cell
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| KO |
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| Organism |
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| Pathway |
| mmu04932 | Non-alcoholic fatty liver disease |
| mmu04950 | Maturity onset diabetes of the young |
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| Module |
| mmu_M00001 | Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate |
| mmu_M00002 | Glycolysis, core module involving three-carbon compounds |
| mmu_M00049 | Adenine ribonucleotide biosynthesis, IMP => ADP,ATP |
| mmu_M00050 | Guanine ribonucleotide biosynthesis IMP => GDP,GTP |
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| Brite |
KEGG Orthology (KO) [BR:mmu00001]
09100 Metabolism
09101 Carbohydrate metabolism
00010 Glycolysis / Gluconeogenesis
18770 (Pklr)
00620 Pyruvate metabolism
18770 (Pklr)
09104 Nucleotide metabolism
00230 Purine metabolism
18770 (Pklr)
09150 Organismal Systems
09152 Endocrine system
04910 Insulin signaling pathway
18770 (Pklr)
09160 Human Diseases
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
18770 (Pklr)
04950 Maturity onset diabetes of the young
18770 (Pklr)
04932 Non-alcoholic fatty liver disease
18770 (Pklr)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:mmu04147]
18770 (Pklr)
Enzymes [BR:mmu01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.1 Phosphotransferases with an alcohol group as acceptor
2.7.1.40 pyruvate kinase
18770 (Pklr)
Exosome [BR:mmu04147]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
18770 (Pklr)
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| SSDB |
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| Motif |
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| Other DBs |
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| Position |
3 F1; 3 39.01 cM
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| AA seq |
543 aa
MEGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSII
ATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFATSPLSYRPV
AIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFRTRGDAKTVWVDYHNITQVV
AVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGFLGNRKGVNLPNAEVDLPGLSEQDLLD
LRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKFDEILEVSD
GIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDV
ANAVLDGADCIMLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDP
TEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLSRG
VFPLLYREPPEAVWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVL
TIS |
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| NT seq |
1632 nt +upstreamnt +downstreamnt
atggaagggccagcaggatacctgagacgtgccagtgtggcccagctgacccaggagctg
ggcactgccttcttccagcagcagcaactgcccgcagctatggcggacaccttcctggaa
cacctctgccttctggatatcgactcagagcctgtggccgctaggagcaccagcatcatt
gccaccatcgggccggcgtcacgctctgtggaccgcctcaaggagatgatcaaggcaggg
atgaacattgcacgactcaacttctcccatggctcccatgagtaccatgcagagtccatc
gccaacattcgggaggcggctgaaagctttgcaacctccccactcagctacagacccgtg
gccatcgccctggacaccaagggtcccgagatacgcactggagtcctgcaggggggtcca
gagtcggaggtggaaattgtgaagggttcacaggtgctggtgactgtggatccgaagttc
cggacaaggggcgatgcaaagacagtgtgggtggactaccacaatatcacccaggtcgtt
gcagtggggggccgcatctacattgacgacgggctcatctccttagtggtgcggaaaatt
ggcccagagggactggtgaccgaagtggaacacggtggtttcttgggcaacaggaagggt
gtgaacttgccaaatgccgaggtggacctgcctgggctatcagagcaagatcttttggat
ctgcgcttcggggtggagcataatgtggacatcatctttgcctcctttgtacgaaaagcc
agtgatgtggtggcagtccgagatgccctagggccagaaggacggggcatcaaaattatc
agcaaaatcgagaaccatgaaggcgtgaagaagtttgatgagatcctagaagtgagcgat
ggcatcatggtggctcggggtgaccttggcattgagatcccagcagagaaggttttcttg
gctcagaagatgatgattggacgctgcaacctggctggcaagcctgtcgtttgtgccaca
cagatgctggagagcatgatcactaaggctcgaccaactcgggcggagacaagcgatgtg
gccaatgctgtgctggatggggctgactgtatcatgctgtctggagagaccgccaaaggc
agtttccccgtggaggctgtaaagatgcaacatgcgattgcccgggaggcagaggccgct
gtgtaccaccgccagttgtttgaggagctacgccgggcagcgccgctgagccgtgaccca
accgaggtcactgcaattggagccgtggaggcttccttcaagtgctgtgccgcagccatc
attgtgctgacaaagactggccgctcagctcagcttctgtctcgctaccgacctcgggct
gctgtcattgctgtgactcgttctgcccaggctgcccgacaggtccacctgtcccgagga
gtcttccccttgctctaccgtgagcctccagaggctgtctgggcagatgatgtggaccga
agggtccaatttggcatcgaaagtggaaagcttcgtggcttcctccgagttggtgatctg
gtgattgtggtgacaggctggcgacctggctctggctataccaacattatgcgggtgctg
accatatcctga |
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