KEGG   Mus musculus (mouse): 18770
Entry
18770             CDS       T01002                                 

Gene name
Pklr, Pk, Pk-, Pk-1, Pk1, R-, R-PK
Definition
(RefSeq) pyruvate kinase liver and red blood cell
  KO
K12406  pyruvate kinase isozymes R/L [EC:2.7.1.40]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu00010  Glycolysis / Gluconeogenesis
mmu00230  Purine metabolism
mmu00620  Pyruvate metabolism
mmu01100  Metabolic pathways
mmu01200  Carbon metabolism
mmu01230  Biosynthesis of amino acids
mmu01240  Biosynthesis of cofactors
mmu04910  Insulin signaling pathway
mmu04930  Type II diabetes mellitus
mmu04932  Non-alcoholic fatty liver disease
mmu04950  Maturity onset diabetes of the young
Module
mmu_M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
mmu_M00002  Glycolysis, core module involving three-carbon compounds
mmu_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP
mmu_M00050  Guanine ribonucleotide biosynthesis IMP => GDP,GTP
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    18770 (Pklr)
   00620 Pyruvate metabolism
    18770 (Pklr)
  09104 Nucleotide metabolism
   00230 Purine metabolism
    18770 (Pklr)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    18770 (Pklr)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    18770 (Pklr)
   04950 Maturity onset diabetes of the young
    18770 (Pklr)
   04932 Non-alcoholic fatty liver disease
    18770 (Pklr)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mmu04147]
    18770 (Pklr)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.40  pyruvate kinase
     18770 (Pklr)
Exosome [BR:mmu04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   18770 (Pklr)
SSDB
Motif
Pfam: PK PK_C IMPDH
Other DBs
NCBI-GeneID: 18770
NCBI-ProteinID: NP_001093249
MGI: 97604
Ensembl: ENSMUSG00000041237
Vega: OTTMUSG00000017504
UniProt: E9Q509 Q3UEI4 Q3UEH4
Position
3 F1; 3 39.01 cM
AA seq 543 aa
MEGPAGYLRRASVAQLTQELGTAFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSII
ATIGPASRSVDRLKEMIKAGMNIARLNFSHGSHEYHAESIANIREAAESFATSPLSYRPV
AIALDTKGPEIRTGVLQGGPESEVEIVKGSQVLVTVDPKFRTRGDAKTVWVDYHNITQVV
AVGGRIYIDDGLISLVVRKIGPEGLVTEVEHGGFLGNRKGVNLPNAEVDLPGLSEQDLLD
LRFGVEHNVDIIFASFVRKASDVVAVRDALGPEGRGIKIISKIENHEGVKKFDEILEVSD
GIMVARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMITKARPTRAETSDV
ANAVLDGADCIMLSGETAKGSFPVEAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDP
TEVTAIGAVEASFKCCAAAIIVLTKTGRSAQLLSRYRPRAAVIAVTRSAQAARQVHLSRG
VFPLLYREPPEAVWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTGWRPGSGYTNIMRVL
TIS
NT seq 1632 nt   +upstreamnt  +downstreamnt
atggaagggccagcaggatacctgagacgtgccagtgtggcccagctgacccaggagctg
ggcactgccttcttccagcagcagcaactgcccgcagctatggcggacaccttcctggaa
cacctctgccttctggatatcgactcagagcctgtggccgctaggagcaccagcatcatt
gccaccatcgggccggcgtcacgctctgtggaccgcctcaaggagatgatcaaggcaggg
atgaacattgcacgactcaacttctcccatggctcccatgagtaccatgcagagtccatc
gccaacattcgggaggcggctgaaagctttgcaacctccccactcagctacagacccgtg
gccatcgccctggacaccaagggtcccgagatacgcactggagtcctgcaggggggtcca
gagtcggaggtggaaattgtgaagggttcacaggtgctggtgactgtggatccgaagttc
cggacaaggggcgatgcaaagacagtgtgggtggactaccacaatatcacccaggtcgtt
gcagtggggggccgcatctacattgacgacgggctcatctccttagtggtgcggaaaatt
ggcccagagggactggtgaccgaagtggaacacggtggtttcttgggcaacaggaagggt
gtgaacttgccaaatgccgaggtggacctgcctgggctatcagagcaagatcttttggat
ctgcgcttcggggtggagcataatgtggacatcatctttgcctcctttgtacgaaaagcc
agtgatgtggtggcagtccgagatgccctagggccagaaggacggggcatcaaaattatc
agcaaaatcgagaaccatgaaggcgtgaagaagtttgatgagatcctagaagtgagcgat
ggcatcatggtggctcggggtgaccttggcattgagatcccagcagagaaggttttcttg
gctcagaagatgatgattggacgctgcaacctggctggcaagcctgtcgtttgtgccaca
cagatgctggagagcatgatcactaaggctcgaccaactcgggcggagacaagcgatgtg
gccaatgctgtgctggatggggctgactgtatcatgctgtctggagagaccgccaaaggc
agtttccccgtggaggctgtaaagatgcaacatgcgattgcccgggaggcagaggccgct
gtgtaccaccgccagttgtttgaggagctacgccgggcagcgccgctgagccgtgaccca
accgaggtcactgcaattggagccgtggaggcttccttcaagtgctgtgccgcagccatc
attgtgctgacaaagactggccgctcagctcagcttctgtctcgctaccgacctcgggct
gctgtcattgctgtgactcgttctgcccaggctgcccgacaggtccacctgtcccgagga
gtcttccccttgctctaccgtgagcctccagaggctgtctgggcagatgatgtggaccga
agggtccaatttggcatcgaaagtggaaagcttcgtggcttcctccgagttggtgatctg
gtgattgtggtgacaggctggcgacctggctctggctataccaacattatgcgggtgctg
accatatcctga

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