KEGG   Mus musculus (mouse): 18783Help
Entry
18783             CDS       T01002                                 

Gene name
Pla2g4a, Pla2g4, cPLA2, cPLA2-alpha, cPLA2alpha
Definition
(RefSeq) phospholipase A2, group IVA (cytosolic, calcium-dependent)
  KO
K16342  cytosolic phospholipase A2 [EC:3.1.1.4]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu00564  Glycerophospholipid metabolism
mmu00565  Ether lipid metabolism
mmu00590  Arachidonic acid metabolism
mmu00591  Linoleic acid metabolism
mmu00592  alpha-Linolenic acid metabolism
mmu01100  Metabolic pathways
mmu04010  MAPK signaling pathway
mmu04014  Ras signaling pathway
mmu04072  Phospholipase D signaling pathway
mmu04217  Necroptosis
mmu04270  Vascular smooth muscle contraction
mmu04370  VEGF signaling pathway
mmu04611  Platelet activation
mmu04664  Fc epsilon RI signaling pathway
mmu04666  Fc gamma R-mediated phagocytosis
mmu04724  Glutamatergic synapse
mmu04726  Serotonergic synapse
mmu04730  Long-term depression
mmu04750  Inflammatory mediator regulation of TRP channels
mmu04912  GnRH signaling pathway
mmu04913  Ovarian steroidogenesis
mmu04921  Oxytocin signaling pathway
mmu05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09103 Lipid metabolism
   00564 Glycerophospholipid metabolism
    18783 (Pla2g4a)
   00565 Ether lipid metabolism
    18783 (Pla2g4a)
   00590 Arachidonic acid metabolism
    18783 (Pla2g4a)
   00591 Linoleic acid metabolism
    18783 (Pla2g4a)
   00592 alpha-Linolenic acid metabolism
    18783 (Pla2g4a)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    18783 (Pla2g4a)
   04010 MAPK signaling pathway
    18783 (Pla2g4a)
   04370 VEGF signaling pathway
    18783 (Pla2g4a)
   04072 Phospholipase D signaling pathway
    18783 (Pla2g4a)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    18783 (Pla2g4a)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    18783 (Pla2g4a)
   04664 Fc epsilon RI signaling pathway
    18783 (Pla2g4a)
   04666 Fc gamma R-mediated phagocytosis
    18783 (Pla2g4a)
  09152 Endocrine system
   04912 GnRH signaling pathway
    18783 (Pla2g4a)
   04913 Ovarian steroidogenesis
    18783 (Pla2g4a)
   04921 Oxytocin signaling pathway
    18783 (Pla2g4a)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    18783 (Pla2g4a)
  09156 Nervous system
   04724 Glutamatergic synapse
    18783 (Pla2g4a)
   04726 Serotonergic synapse
    18783 (Pla2g4a)
   04730 Long-term depression
    18783 (Pla2g4a)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    18783 (Pla2g4a)
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    18783 (Pla2g4a)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.4  phospholipase A2
     18783 (Pla2g4a)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PLA2_B C2
Motif
Other DBs
NCBI-GeneID: 18783
NCBI-ProteinID: NP_032895
MGI: 1195256
Ensembl: ENSMUSG00000056220
Vega: OTTMUSG00000016429
UniProt: P47713 Q3UMQ1
Position
1 G1; 1 63.51 cM
AA seq 748 aa AA seqDB search
MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGTFGDMLDTPDPYVELFISTTPDSRKRT
RHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFPVSSMKVGEKKEV
PFIFNQVTEMILEMSLEVCSCPDLRFSMALCDQEKTFRQQRKENIKENMKKLLGPKKSEG
LYSTRDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYIAGLSGSTWYMSTLYSH
PDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIG
ETLIQNRMSMTLSSLKEKVNAARCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYG
TFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQNKGSTMEEE
LENITAKHIVSNDSSDSDDEAQGPKGTENEEAEKEYQSDNQASWVHRMLMALVSDSALFN
TREGRAGKVHNFMLGLNLNTSYPLSPLRDFSSQDSFDDELDAAVADPDEFERIYEPLDVK
SKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDTSPPFKELLLAEKWAKMNK
LPFPKIDPYVFDREGLKECYVFKPKNPDVEKDCPTIIHFVLANINFRKYKAPGVLRETKE
EKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMYFNTLNNIDVIKDAIVESIEYRRQ
NPSRCSVSLSNVEARKFFNKEFLSKPTV
NT seq 2247 nt NT seq  +upstreamnt  +downstreamnt
atgtctttcatagatccttatcagcacattatagtggaacaccagtactcccataagttt
actgttgtggttctacgtgccaccaaagtaaccaaggggacctttggcgatatgctggac
actccagatccttatgtggaacttttcatctctacaacccctgacagcaggaagcgaacg
agacacttcaataatgatataaaccccgtgtggaatgagacctttgagttcattttggat
cctaatcaggaaaatgttttggagatcacactgatggatgccaactacgtcatggatgaa
accctaggcacagctacattccctgtatcttcaatgaaagtgggagagaagaaagaagtc
ccttttattttcaaccaagtcactgaaatgattctggaaatgtctctggaagtttgttca
tgcccagacctacggttcagcatggcactgtgtgatcaggagaaaactttcagacagcag
aggaaagagaacataaaagagaacatgaagaaacttttgggtccaaaaaagagtgagggg
ctttattccacacgtgatgtgccggtggtggccattttgggttcaggtgggggtttccgg
gccatggtgggattctctggtgtgatgaaggcactgtatgagtcggggattttggactgt
gctacatacattgctggtctttctggatccacatggtacatgtcaaccttgtactctcac
cccgattttccagagaaaggtcccgaggagattaatgaagagctaatgaaaaatgtcagc
cacaaccctctcttacttcttacaccacagaaagttaaaagatacgttgagtctttatgg
aagaagaaaagttctggccagcctgtcacctttactgacatctttgggatgctaatagga
gaaacactaattcaaaataggatgagcatgaccctgagtagtttgaaggaaaaggtcaat
gccgcccggtgtcctttgcctctcttcacgtgtctccacgtcaaacctgatgtgtcagag
ctgatgtttgccgattgggtggaatttagtccatatgagattggcatggcaaaatatggt
acctttatggctcctgacctatttggaagcaagttttttatgggaacagttgtaaaaaaa
tatgaagaaaaccccttgcatttcttgatgggtgtctggggcagtgccttttctatactg
ttcaacagagttttgggagtttctggctcacagaataaaggctctacaatggaagaggaa
ttagaaaatattacagcaaagcacatcgtgagtaatgacagctccgacagtgatgatgag
gctcaaggacccaaaggcaccgagaatgaagaagctgaaaaagagtaccaaagcgacaac
caagcaagttgggtccatcggatgctaatggccttggtgagcgactcggctttattcaat
acccgagaaggacgtgccggaaaggtgcataacttcatgctgggcttgaatctcaacaca
tcatatccactgtctcccctgagagacttcagctctcaggattccttcgatgacgagctc
gacgcagcggtagcagatccagatgaatttgaacgaatatatgaaccactggatgtcaaa
agtaagaagattcatgtggtagatagtgggctcacatttaacctgccatatcccttgatt
cttcgacctcagagaggtgtggatcttatcatctcctttgacttttctgcaaggccgagt
gacaccagtccccctttcaaggaacttctgcttgcagagaagtgggcgaaaatgaacaag
cttccctttccaaagatcgatccttatgtgtttgatcgggaaggattaaaggaatgctat
gtttttaaacctaagaatcctgatgtggagaaggattgcccaaccattatccactttgtt
ctggccaacatcaacttcagaaagtacaaggccccaggtgttctaagggaaaccaaagaa
gagaaagaaattgctgactttgacatttttgatgaccccgaatcgccattttcaaccttc
aactttcagtatcccaatcaagcattcaaaaggcttcacgatttgatgtacttcaacaca
ctgaacaacattgatgtgataaaggatgccattgttgagagcattgaatacagaagacag
aacccatctcgttgctctgtttccctcagtaatgttgaagcaagaaaattcttcaataag
gagtttctaagtaaacccactgtgtaa

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