KEGG   Mus musculus (mouse): 18795Help
Entry
18795             CDS       T01002                                 

Gene name
Plcb1, 3110043I21Rik, AI132408, Plcb, mKIAA0581
Definition
(RefSeq) phospholipase C, beta 1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu00562  Inositol phosphate metabolism
mmu01100  Metabolic pathways
mmu04015  Rap1 signaling pathway
mmu04020  Calcium signaling pathway
mmu04022  cGMP-PKG signaling pathway
mmu04062  Chemokine signaling pathway
mmu04070  Phosphatidylinositol signaling system
mmu04071  Sphingolipid signaling pathway
mmu04072  Phospholipase D signaling pathway
mmu04261  Adrenergic signaling in cardiomyocytes
mmu04270  Vascular smooth muscle contraction
mmu04310  Wnt signaling pathway
mmu04371  Apelin signaling pathway
mmu04540  Gap junction
mmu04611  Platelet activation
mmu04621  NOD-like receptor signaling pathway
mmu04713  Circadian entrainment
mmu04720  Long-term potentiation
mmu04723  Retrograde endocannabinoid signaling
mmu04724  Glutamatergic synapse
mmu04725  Cholinergic synapse
mmu04726  Serotonergic synapse
mmu04728  Dopaminergic synapse
mmu04730  Long-term depression
mmu04750  Inflammatory mediator regulation of TRP channels
mmu04911  Insulin secretion
mmu04912  GnRH signaling pathway
mmu04915  Estrogen signaling pathway
mmu04916  Melanogenesis
mmu04918  Thyroid hormone synthesis
mmu04919  Thyroid hormone signaling pathway
mmu04921  Oxytocin signaling pathway
mmu04922  Glucagon signaling pathway
mmu04924  Renin secretion
mmu04925  Aldosterone synthesis and secretion
mmu04926  Relaxin signaling pathway
mmu04927  Cortisol synthesis and secretion
mmu04928  Parathyroid hormone synthesis, secretion and action
mmu04929  GnRH secretion
mmu04933  AGE-RAGE signaling pathway in diabetic complications
mmu04934  Cushing syndrome
mmu04935  Growth hormone synthesis, secretion and action
mmu04961  Endocrine and other factor-regulated calcium reabsorption
mmu04970  Salivary secretion
mmu04971  Gastric acid secretion
mmu04972  Pancreatic secretion
mmu04973  Carbohydrate digestion and absorption
mmu05010  Alzheimer disease
mmu05016  Huntington disease
mmu05142  Chagas disease (American trypanosomiasis)
mmu05143  African trypanosomiasis
mmu05146  Amoebiasis
mmu05163  Human cytomegalovirus infection
mmu05200  Pathways in cancer
Module
mmu_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    18795 (Plcb1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    18795 (Plcb1)
   04310 Wnt signaling pathway
    18795 (Plcb1)
   04371 Apelin signaling pathway
    18795 (Plcb1)
   04020 Calcium signaling pathway
    18795 (Plcb1)
   04070 Phosphatidylinositol signaling system
    18795 (Plcb1)
   04072 Phospholipase D signaling pathway
    18795 (Plcb1)
   04071 Sphingolipid signaling pathway
    18795 (Plcb1)
   04022 cGMP-PKG signaling pathway
    18795 (Plcb1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    18795 (Plcb1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    18795 (Plcb1)
   04621 NOD-like receptor signaling pathway
    18795 (Plcb1)
   04062 Chemokine signaling pathway
    18795 (Plcb1)
  09152 Endocrine system
   04911 Insulin secretion
    18795 (Plcb1)
   04922 Glucagon signaling pathway
    18795 (Plcb1)
   04929 GnRH secretion
    18795 (Plcb1)
   04912 GnRH signaling pathway
    18795 (Plcb1)
   04915 Estrogen signaling pathway
    18795 (Plcb1)
   04921 Oxytocin signaling pathway
    18795 (Plcb1)
   04926 Relaxin signaling pathway
    18795 (Plcb1)
   04935 Growth hormone synthesis, secretion and action
    18795 (Plcb1)
   04918 Thyroid hormone synthesis
    18795 (Plcb1)
   04919 Thyroid hormone signaling pathway
    18795 (Plcb1)
   04928 Parathyroid hormone synthesis, secretion and action
    18795 (Plcb1)
   04916 Melanogenesis
    18795 (Plcb1)
   04924 Renin secretion
    18795 (Plcb1)
   04925 Aldosterone synthesis and secretion
    18795 (Plcb1)
   04927 Cortisol synthesis and secretion
    18795 (Plcb1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    18795 (Plcb1)
   04270 Vascular smooth muscle contraction
    18795 (Plcb1)
  09154 Digestive system
   04970 Salivary secretion
    18795 (Plcb1)
   04971 Gastric acid secretion
    18795 (Plcb1)
   04972 Pancreatic secretion
    18795 (Plcb1)
   04973 Carbohydrate digestion and absorption
    18795 (Plcb1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    18795 (Plcb1)
  09156 Nervous system
   04724 Glutamatergic synapse
    18795 (Plcb1)
   04725 Cholinergic synapse
    18795 (Plcb1)
   04728 Dopaminergic synapse
    18795 (Plcb1)
   04726 Serotonergic synapse
    18795 (Plcb1)
   04720 Long-term potentiation
    18795 (Plcb1)
   04730 Long-term depression
    18795 (Plcb1)
   04723 Retrograde endocannabinoid signaling
    18795 (Plcb1)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    18795 (Plcb1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    18795 (Plcb1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    18795 (Plcb1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    18795 (Plcb1)
   05016 Huntington disease
    18795 (Plcb1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    18795 (Plcb1)
   04934 Cushing syndrome
    18795 (Plcb1)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    18795 (Plcb1)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    18795 (Plcb1)
   05142 Chagas disease (American trypanosomiasis)
    18795 (Plcb1)
   05143 African trypanosomiasis
    18795 (Plcb1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmu04131]
    18795 (Plcb1)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     18795 (Plcb1)
Membrane trafficking [BR:mmu04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    18795 (Plcb1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    18795 (Plcb1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PI-PLC-X PLC-beta_C PH_14 PI-PLC-Y EF-hand_like DUF1154
Motif
Other DBs
NCBI-GeneID: 18795
NCBI-ProteinID: NP_001139302
MGI: 97613
Ensembl: ENSMUSG00000051177
Vega: OTTMUSG00000015592
UniProt: Q9Z1B3 Q3UPW0
Position
2 F3; 2 65.66 cM
AA seq 1216 aa AA seqDB search
MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE
TELLDLSLVKDARCGKHAKAPKDPKLRELLDVGNIGHLEQRMITVVYGPDLVNISHLNLV
AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA
DRKRVETALEACSLPSSRNDSIPQEDFTPDVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL
TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKKGQMSVDGFMRYLS
GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV
ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ
QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK
KLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM
SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK
GTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK
HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG
NAVNPVWEEEPIVFKKVVLPSLACLRIAAYEEGGKFIGHRILPVQAIRPGYHYICLRNER
NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK
EADPGETSSEAPSETRTTPAENGVNHTASLAPKPPSQAPHSQPAPGSVKAPAKTEDLIQS
VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTELIKEHTTKYNEIQNDYL
RRRAALEKSAKKDSKKKSEPSSPDHGSSAIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR
QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI
TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHNEIRQQILDEKP
KLQTELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPPSLASDAAKVNLKSPSS
EEIERENPGREFDTPL
NT seq 3651 nt NT seq  +upstreamnt  +downstreamnt
atggctggggctcagcccggagtgcacgccttgcaactcaagcccgtgtgcgtgtccgac
agcctcaagaagggcaccaaattcgtcaagtgggatgatgactccactattgttactcca
attattttgaggactgatcctcagggatttttcttttactggacagaccagaataaggag
acggagctgttagatctcagccttgtcaaggatgccaggtgtgggaagcacgccaaagct
cccaaggaccccaagttgcgtgaacttctggatgttgggaacatcggacacttggaacag
cgcatgataactgtggtgtatggaccagacctggtgaacatttcccacttgaatcttgtg
gcttttcaagaggaagtagccaaggaatggacaaatgaggttttcagcttggcaacaaac
ctgctggctcagaacatgtccagggacgcatttctggagaaagcatatactaagctcaag
ctccaggtcaccccagaaggccgcattcctcttaaaaacatctatcgattgttctcagca
gaccggaagcgcgttgaaactgcactagaggcttgtagtcttccatcttcgaggaatgac
tccattccccaagaggacttcactccagatgtatacagagttttcctgaacaatctctgt
ccccgacctgaaattgataacatcttttctgaatttggtgccaaaagcaaaccgtacctg
acggttgatcagatgatggattttatcaaccttaagcagagagatccccggctcaatgaa
atcctttacccacctctgaagcaggagcaggtccaagtgttgattgagaaatatgagccc
aacagcagcctcgccaagaaagggcagatgtcagtggatggattcatgcgctacctgagc
ggagaagaaaatggagtcgtttcacctgagaaactggatttgaacgaagacatgtctcag
cccctgtctcactatttcatcaattcctcgcacaacacctacctcacagctggccagttg
gctgggaactcgtctgtagagatgtatcgccaggtgcttctgtctggatgtcgctgtgtg
gagctggactgctggaagggaaggaccgctgaggaagagcctgtcattacccatggattc
accatgacaacagaaatatccttcaaggaagtcatagaagccatcgcagagtgtgcgttc
aagacgtctcctttccccatcctcctttcctttgagaaccacgtggattccccgaagcaa
caagccaagatggccgagtattgccgattaatctttggtgatgccctcctgatggaacca
ctggaaaaatacccactggaatctggggtacctcttccaagccctatggatttaatgtat
aaaatcttggtgaaaaacaagaagaagtcgcacaagtcgtcagagggaagtggtaagaag
aagctttcagagcaagcttccaacacctacagcgactcctccagtgtgttcgagccttcg
tctccaggagctggggaagcagatacggagagtgatgacgatgacgacgacgatgactgt
aaaaagtcttccatggatgaggggacagctggcagcgaagccatggccacagaagagatg
tctaacctggtgaactatattcagcctgtcaagtttgagtcctttgaaatttcaaaaaaa
agaaataaaagctttgaaatgtcttccttcgtggaaaccaaaggacttgaacaacttaca
aagtctccggtggaatttgtagaatacaacaagatgcaacttagcaggatatatcccaag
ggaacacgtgtggattcatccaactacatgcctcaactcttctggaatgctggctgtcag
atggtggcgctcaacttccagacagtggatctagctatgcagataaacatgggcatgtat
gagtacaatgggaagagcggctataggctgaagccagagttcatgaggaggccggacaag
cattttgatccatttactgaaggaatcgtagatgggatagtggccaacactctatctgtt
aagattatttcaggtcagttcctctctgataagaaagttgggacttatgtggaagtggat
atgtttggcttgcctgtggacacaaggaggaaggcatttaaaaccaagacatcccaagga
aatgctgtaaaccctgtctgggaagaagaacctattgtattcaaaaaggtagttctacct
tctctggcctgtttgaggatagcagcatatgaagagggaggcaaatttattggccaccgg
atattgcctgtgcaggctattcggccaggctatcactacatctgcctgcggaatgagagg
aaccagcccctgacgctgccagctgtctttgtctacatagaagtcaaagattatgtgcca
gacacgtatgcagatgtaatcgaagctctatcaaacccaatccgatatgtcaatctgatg
gaacagagagctaagcagctggctgcgttgaccctggaggatgaagaggaagtaaagaag
gaggctgaccctggagaaacatcttccgaggctccaagcgaaaccaggacaacgccagca
gagaatggggtgaatcacaccgcatcccttgcacccaagccgccttcccaggctccacac
agccagcctgctccagggtctgtgaaggcacctgccaaaacagaagatctgatccagagc
gtgttaacagaagtagaggcgcaaaccatcgaagagctcaagcaacagaaatcgttcgtg
aaacttcaaaagaaacactacaaagaaatgaaagacctggtgaagagacaccacaagaaa
accacggagctcattaaggagcacacgaccaagtacaacgagattcagaatgactacctg
agaaggagggcagccttggagaagtccgccaaaaaggacagcaagaagaaatctgaaccc
agcagccctgaccacggctcatcagccattgagcaagacctcgctgccctggatgcagaa
atgactcagaagttgatagacttgaaagacaagcaacaacagcagctgcttaatcttcgg
caagagcagtattacagcgagaagtaccaaaagcgagaacacattaaactgcttattcag
aagttgacagatgttgcagaagagtgtcagaacaatcagttaaagaagctgaaggaaatc
tgcgagaaagagaagaaggaattaaagaagaaaatggataagaagaggcaagagaagata
acagaagccaagtccaaagacaaaagccagatggaagaggagaagacagagatgatccga
tcgtacatccaggaggtggttcagtacatcaagaggttagaggaagcacaaagtaaaaga
caagaaaaactcgtggagaaacacaatgagatccgccagcagatcctcgatgagaagccc
aagctgcagacggagctggagcaagaataccaagacaagttcaaaaggctgcccctggag
attctggagtttgtacaggaagccatgaaagggaagatcagcgaggacagcaatcacggc
tctgcccctccctctctggcctcagatgctgcaaaggtgaacctcaagtctccctccagt
gaggagatagaaagagagaacccaggaagagagtttgatactcctctgtga

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