KEGG   Mus musculus (house mouse): 19106
Entry
19106             CDS       T01002                                 
Symbol
Eif2ak2, 2310047A08Rik, 4732414G15Rik, Pkr, Prkr, Tik
Name
(RefSeq) eukaryotic translation initiation factor 2-alpha kinase 2
  KO
K16195  eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04217  Necroptosis
mmu05010  Alzheimer disease
mmu05160  Hepatitis C
mmu05162  Measles
mmu05164  Influenza A
mmu05165  Human papillomavirus infection
mmu05167  Kaposi sarcoma-associated herpesvirus infection
mmu05168  Herpes simplex virus 1 infection
mmu05169  Epstein-Barr virus infection
mmu05171  Coronavirus disease - COVID-19
mmu05203  Viral carcinogenesis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    19106 (Eif2ak2)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    19106 (Eif2ak2)
  09172 Infectious disease: viral
   05160 Hepatitis C
    19106 (Eif2ak2)
   05171 Coronavirus disease - COVID-19
    19106 (Eif2ak2)
   05164 Influenza A
    19106 (Eif2ak2)
   05162 Measles
    19106 (Eif2ak2)
   05168 Herpes simplex virus 1 infection
    19106 (Eif2ak2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    19106 (Eif2ak2)
   05169 Epstein-Barr virus infection
    19106 (Eif2ak2)
   05165 Human papillomavirus infection
    19106 (Eif2ak2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    19106 (Eif2ak2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    19106 (Eif2ak2)
   01009 Protein phosphatases and associated proteins [BR:mmu01009]
    19106 (Eif2ak2)
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:mmu03019]
    19106 (Eif2ak2)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     19106 (Eif2ak2)
Protein kinases [BR:mmu01001]
 Serine/threonine kinases: Other
  PEK family [OT]
   19106 (Eif2ak2)
Protein phosphatases and associated proteins [BR:mmu01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     19106 (Eif2ak2)
Messenger RNA biogenesis [BR:mmu03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     19106 (Eif2ak2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr dsrm DSRM_2 ABC1 Pkinase_fungal Kinase-like DND1_DSRM Kdo
Other DBs
NCBI-GeneID: 19106
NCBI-ProteinID: NP_035293
MGI: 1353449
Ensembl: ENSMUSG00000024079
UniProt: Q03963
Structure
Position
17:complement(79157933..79190001)
AA seq 515 aa
MASDTPGFYMDKLNKYRQMHGVAITYKELSTSGPPHDRRFTFQVLIDEKEFPEAKGRSKQ
EARNAAAKLAVDILDNENKVDCHTSASEQGLFVGNYIGLVNSFAQKKKLSVNYEQCEPNS
ELPQRFICKCKIGQTMYGTGSGVTKQEAKQLAAKEAYQKLLKSPPKTAGTSSSVVTSTFS
GFSSSSSMTSNGVSQSAPGSFSSENVFTNGLGENKRKSGVKVSPDDVQRNKYTLDARFNS
DFEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRVKYNTEKAEHEVQALAELNHVNIVQYHS
CWEGVDYDPEHSMSDTSRYKTRCLFIQMEFCDKGTLEQWMRNRNQSKVDKALILDLYEQI
VTGVEYIHSKGLIHRDLKPGNIFLVDERHIKIGDFGLATALENDGKSRTRRTGTLQYMSP
EQLFLKHYGKEVDIFALGLILAELLHTCFTESEKIKFFESLRKGDFSNDIFDNKEKSLLK
KLLSEKPKDRPETSEILKTLAEWRNISEKKKRNTC
NT seq 1548 nt   +upstreamnt  +downstreamnt
atggccagtgataccccaggtttctacatggacaaacttaataaataccgccagatgcac
ggagtagccattacgtataaagaacttagtacttcgggacctccacatgacagaaggttt
acatttcaagttttaatagatgagaaggaatttccagaagccaaaggtagatcaaagcag
gaggcaagaaacgctgcagccaaattagctgttgatatacttgataacgaaaacaaggtg
gattgtcacacgagtgcatctgagcaaggcttgttcgttggtaactacataggccttgtc
aatagctttgcccagaagaaaaagctgtctgtaaattatgaacagtgtgagcccaactct
gagttgcctcaaagatttatttgtaaatgcaaaattgggcagacaatgtatggtactggt
tcaggtgtcaccaaacaggaggcaaagcagttggctgcgaaagaagcctatcagaagctg
ttaaagagcccgccgaaaactgccggaacatcctctagcgttgtcacatctacattcagt
ggcttttccagcagctcgtctatgacaagtaatggtgtttcccagtcagcacctggaagt
ttttcctcagagaacgtgtttacgaacggtctcggagaaaataaaaggaaatcaggagta
aaagtatcccctgatgatgtgcaaagaaataaatataccttggacgccaggtttaacagc
gattttgaagacatagaagaaattggcttaggtggatttggtcaagttttcaaagcgaaa
cacagaattgatggaaagagatacgctattaagcgcgttaaatataacacggagaaggcg
gagcacgaagtacaagcgctggcagaactcaatcacgtcaacattgtccaataccatagt
tgttgggagggagttgactatgatcctgagcacagcatgagtgatacaagtcgatacaaa
acccggtgcctctttattcaaatggaattctgtgataaaggaactttggagcaatggatg
agaaacagaaatcagagtaaagtggacaaagctttgattttggacttatatgaacaaatc
gtgaccggagtggagtatatacactcgaaagggttaattcacagagatcttaagccaggt
aatatatttttagtagatgaaagacacattaagatcggagactttggccttgcaacagcc
ctggaaaatgatggaaaatcccgaacaaggagaacaggaactcttcaatacatgagtcca
gaacagttatttttaaagcactatggaaaagaagtggacatctttgctttgggccttatt
ctagctgaacttcttcacacgtgcttcacggagtcagagaaaataaagtttttcgaaagt
ctaagaaaaggcgacttctctaatgatatattcgacaacaaagaaaaaagccttctaaaa
aaactactctcagagaaacccaaggaccgacctgagacatctgaaatcctgaagaccttg
gctgaatggaggaacatctcagagaaaaagaaaagaaacacatgttag

  All links  
Gene (48)   
   RefGene (43)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (18)   
   RefSeq(nuc) (2)   
   GenBank (8)   
   EMBL (8)   
3D Structure (2)   
   PDB (2)   
Protein domain (9)   
   Pfam (9)   
All databases (81)   

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