KEGG   Mus musculus (mouse): 19106
Entry
19106             CDS       T01002                                 

Gene name
Eif2ak2, 2310047A08Rik, 4732414G15Rik, AI467567, AI747578, P, Pkr, Prkr, Ti, Tik
Definition
(RefSeq) eukaryotic translation initiation factor 2-alpha kinase 2
  KO
K16195  eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu04141  Protein processing in endoplasmic reticulum
mmu04217  Necroptosis
mmu05010  Alzheimer disease
mmu05160  Hepatitis C
mmu05162  Measles
mmu05164  Influenza A
mmu05165  Human papillomavirus infection
mmu05167  Kaposi sarcoma-associated herpesvirus infection
mmu05168  Herpes simplex virus 1 infection
mmu05169  Epstein-Barr virus infection
mmu05171  Coronavirus disease - COVID-19
mmu05203  Viral carcinogenesis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    19106 (Eif2ak2)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    19106 (Eif2ak2)
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    19106 (Eif2ak2)
  09172 Infectious disease: viral
   05160 Hepatitis C
    19106 (Eif2ak2)
   05171 Coronavirus disease - COVID-19
    19106 (Eif2ak2)
   05164 Influenza A
    19106 (Eif2ak2)
   05162 Measles
    19106 (Eif2ak2)
   05168 Herpes simplex virus 1 infection
    19106 (Eif2ak2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    19106 (Eif2ak2)
   05169 Epstein-Barr virus infection
    19106 (Eif2ak2)
   05165 Human papillomavirus infection
    19106 (Eif2ak2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    19106 (Eif2ak2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    19106 (Eif2ak2)
   01009 Protein phosphatases and associated proteins [BR:mmu01009]
    19106 (Eif2ak2)
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis [BR:mmu03019]
    19106 (Eif2ak2)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     19106 (Eif2ak2)
Protein kinases [BR:mmu01001]
 Serine/threonine kinases: Other
  PEK family [OT]
   19106 (Eif2ak2)
Protein phosphatases and associated proteins [BR:mmu01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     19106 (Eif2ak2)
Messenger RNA biogenesis [BR:mmu03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    P-body specific factors
     19106 (Eif2ak2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr dsrm Pkinase_fungal Kdo Kinase-like APH DND1_DSRM
Other DBs
NCBI-GeneID: 19106
NCBI-ProteinID: NP_035293
MGI: 1353449
Ensembl: ENSMUSG00000024079
Vega: OTTMUSG00000036019
UniProt: Q03963
Structure
PDB: 
1X48 1X49

Position
17 E3; 17 49.56 cM
AA seq 515 aa
MASDTPGFYMDKLNKYRQMHGVAITYKELSTSGPPHDRRFTFQVLIDEKEFPEAKGRSKQ
EARNAAAKLAVDILDNENKVDCHTSASEQGLFVGNYIGLVNSFAQKKKLSVNYEQCEPNS
ELPQRFICKCKIGQTMYGTGSGVTKQEAKQLAAKEAYQKLLKSPPKTAGTSSSVVTSTFS
GFSSSSSMTSNGVSQSAPGSFSSENVFTNGLGENKRKSGVKVSPDDVQRNKYTLDARFNS
DFEDIEEIGLGGFGQVFKAKHRIDGKRYAIKRVKYNTEKAEHEVQALAELNHVNIVQYHS
CWEGVDYDPEHSMSDTSRYKTRCLFIQMEFCDKGTLEQWMRNRNQSKVDKALILDLYEQI
VTGVEYIHSKGLIHRDLKPGNIFLVDERHIKIGDFGLATALENDGKSRTRRTGTLQYMSP
EQLFLKHYGKEVDIFALGLILAELLHTCFTESEKIKFFESLRKGDFSNDIFDNKEKSLLK
KLLSEKPKDRPETSEILKTLAEWRNISEKKKRNTC
NT seq 1548 nt   +upstreamnt  +downstreamnt
atggccagtgataccccaggtttctacatggacaaacttaataaataccgccagatgcac
ggagtagccattacgtataaagaacttagtacttcgggacctccacatgacagaaggttt
acatttcaagttttaatagatgagaaggaatttccagaagccaaaggtagatcaaagcag
gaggcaagaaacgctgcagccaaattagctgttgatatacttgataacgaaaacaaggtg
gattgtcacacgagtgcatctgagcaaggcttgttcgttggtaactacataggccttgtc
aatagctttgcccagaagaaaaagctgtctgtaaattatgaacagtgtgagcccaactct
gagttgcctcaaagatttatttgtaaatgcaaaattgggcagacaatgtatggtactggt
tcaggtgtcaccaaacaggaggcaaagcagttggctgcgaaagaagcctatcagaagctg
ttaaagagcccgccgaaaactgccggaacatcctctagcgttgtcacatctacattcagt
ggcttttccagcagctcgtctatgacaagtaatggtgtttcccagtcagcacctggaagt
ttttcctcagagaacgtgtttacgaacggtctcggagaaaataaaaggaaatcaggagta
aaagtatcccctgatgatgtgcaaagaaataaatataccttggacgccaggtttaacagc
gattttgaagacatagaagaaattggcttaggtggatttggtcaagttttcaaagcgaaa
cacagaattgatggaaagagatacgctattaagcgcgttaaatataacacggagaaggcg
gagcacgaagtacaagcgctggcagaactcaatcacgtcaacattgtccaataccatagt
tgttgggagggagttgactatgatcctgagcacagcatgagtgatacaagtcgatacaaa
acccggtgcctctttattcaaatggaattctgtgataaaggaactttggagcaatggatg
agaaacagaaatcagagtaaagtggacaaagctttgattttggacttatatgaacaaatc
gtgaccggagtggagtatatacactcgaaagggttaattcacagagatcttaagccaggt
aatatatttttagtagatgaaagacacattaagatcggagactttggccttgcaacagcc
ctggaaaatgatggaaaatcccgaacaaggagaacaggaactcttcaatacatgagtcca
gaacagttatttttaaagcactatggaaaagaagtggacatctttgctttgggccttatt
ctagctgaacttcttcacacgtgcttcacggagtcagagaaaataaagtttttcgaaagt
ctaagaaaaggcgacttctctaatgatatattcgacaacaaagaaaaaagccttctaaaa
aaactactctcagagaaacccaaggaccgacctgagacatctgaaatcctgaagaccttg
gctgaatggaggaacatctcagagaaaaagaaaagaaacacatgttag

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (12)   
   KEGG PATHWAY (12)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (51)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (43)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (4)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (18)   
   RefSeq(nuc) (2)   
   GenBank (8)   
   EMBL (8)   
Protein domain (8)   
   Pfam (8)   
All databases (100)   

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