KEGG   Mus musculus (mouse): 20541
Entry
20541             CDS       T01002                                 

Gene name
Slc8a1, AI852629, AV344025, D930008O12Rik, Ncx, Ncx1
Definition
(RefSeq) solute carrier family 8 (sodium/calcium exchanger), member 1
  KO
K05849  solute carrier family 8 (sodium/calcium exchanger)
Organism
mmu  Mus musculus (mouse)
Pathway
mmu04020  Calcium signaling pathway
mmu04022  cGMP-PKG signaling pathway
mmu04260  Cardiac muscle contraction
mmu04261  Adrenergic signaling in cardiomyocytes
mmu04371  Apelin signaling pathway
mmu04740  Olfactory transduction
mmu04961  Endocrine and other factor-regulated calcium reabsorption
mmu04974  Protein digestion and absorption
mmu04978  Mineral absorption
mmu05410  Hypertrophic cardiomyopathy
mmu05412  Arrhythmogenic right ventricular cardiomyopathy
mmu05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    20541 (Slc8a1)
   04020 Calcium signaling pathway
    20541 (Slc8a1)
   04022 cGMP-PKG signaling pathway
    20541 (Slc8a1)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    20541 (Slc8a1)
   04261 Adrenergic signaling in cardiomyocytes
    20541 (Slc8a1)
  09154 Digestive system
   04974 Protein digestion and absorption
    20541 (Slc8a1)
   04978 Mineral absorption
    20541 (Slc8a1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    20541 (Slc8a1)
  09157 Sensory system
   04740 Olfactory transduction
    20541 (Slc8a1)
 09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    20541 (Slc8a1)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    20541 (Slc8a1)
   05414 Dilated cardiomyopathy
    20541 (Slc8a1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:mmu02000]
    20541 (Slc8a1)
   00536 Glycosaminoglycan binding proteins [BR:mmu00536]
    20541 (Slc8a1)
Transporters [BR:mmu02000]
 Solute carrier family (SLC)
  SLC8: Na+/Ca2+ exchanger
   20541 (Slc8a1)
Glycosaminoglycan binding proteins [BR:mmu00536]
 Heparan sulfate / Heparin
  Others
   20541 (Slc8a1)
SSDB
Motif
Pfam: Calx-beta Na_Ca_ex Na_Ca_ex_C DnaG_DnaB_bind
Other DBs
NCBI-GeneID: 20541
NCBI-ProteinID: NP_035536
MGI: 107956
Ensembl: ENSMUSG00000054640
UniProt: P70414 G3X9J1 Q68FL0
Position
17 E3; 17 51.29 cM
AA seq 970 aa
MLRLSLPPNVSMGFRLVALVALLFSHVDHITADTEAETGGNETTECTGSYYCKKGVILPI
WEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETT
KTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIII
ALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVSSPGVVEVWEGLLTFFFFP
ICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPASKTEIEMDGKVVNSHVDNF
LDGALVLEVDERDQDDEEARREMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAF
YRIQATRLMTGAGNILKRHAADQARKAVSMHEVNMEMAENDPVSKIFFEQGTYQCLENCG
TVALTIMRRGGDLSTTVFVDFRTEDGTANAGSDYEFTEGTVIFKPGETQKEIRVGIIDDD
IFEEDENFLVHLSNVRVSSDVSEDGILESNHASSIACLGSPSTATITIFDDDHAGIFTFE
EPVTHVSESIGIMEVKVLRTSGARGNVIIPYKTIEGTARGGGEDFEDTCGELEFQNDEIV
KTISVKVIDDEEYEKNKTFFIEIGEPRLVEMSEKKALLLNELGGFTLTGKEMYGQPIFRK
VHARDHPIPSTVITISEEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFK
STVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTV
FWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVAL
GTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVS
PGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSSLFVLLWLLYIFFSS
LEAYCHIKGF
NT seq 2913 nt   +upstreamnt  +downstreamnt
atgcttcgattaagtctcccacccaatgtttcaatgggatttcgtctggtagctctggtg
gctctcttgttttcccatgttgaccatataactgcagatacagaggcagaaacaggagga
aatgaaaccactgaatgtactggctcatattactgtaagaaaggggtgatcttgcccatt
tgggaaccccaagacccatcttttggggacaaaattgctagagcaactgtgtattttgtg
gccatggtctacatgttccttggagtttctattattgcagaccggtttatgtcctctata
gaggtcatcacctctcaagagaaagaaataacgataaagaaaccgaatggagagaccacc
aagacgacggtgagaatctggaacgagactgtgtcgaacctgaccttgatggccctggga
tcttctgctcctgagattctcctgtcagtcattgaagtgtgcggccataacttcaccgca
ggggacctgggtcccagcaccatcgtgggaagtgctgcctttaacatgttcatcataatc
gcactctgtgtttacgtggtccctgatggagagacaaggaagatcaagcatctgcgtgtg
ttctttgtgacagcagcctggagcatctttgcctatacctggctttatataatcttgtct
gtcagctctcctggagttgtggaggtctgggaaggcttgcttactttcttcttctttccc
atctgcgttgtgttcgcgtgggtagcagacaggcggcttctcttttacaagtatgtctac
aagcggtacagggccggcaagcagagggggatgatcattgaacatgaaggagacagacca
gcttccaaaactgaaatcgaaatggatgggaaagtggtcaactctcatgttgacaatttc
ttagatggggctctggttttggaagttgatgagagggaccaagatgatgaggaagccagg
cgtgagatggcaaggattctgaaggaacttaagcagaagcatcctgagaaagaaattgag
caattaatagaattagccaactaccaggtcctaagtcaacagcagaaaagccgagcattt
tacaggattcaagctactcgcctgatgaccggagctggcaacatcttgaagaggcacgca
gctgatcaagcaaggaaggctgtcagtatgcatgaagtcaacatggaaatggctgaaaac
gacccagtcagtaagatcttctttgagcaaggaacataccagtgtctagagaactgtggt
actgtggccctcaccattatgcgcagagggggcgacttgagcaccactgtgtttgttgac
ttcaggacagaagacggcacagccaatgctgggtctgattatgaattcacggaagggact
gtgatcttcaaaccaggggagacccagaaggaaatcagagttggcatcattgatgatgat
atctttgaagaagatgaaaacttccttgtgcatcttagcaatgtcagagtctcttcagat
gtttcagaagatggcatactagaatccaatcacgcttcttcaattgcttgtcttgggtca
cccagcactgccaccataaccatttttgatgatgaccatgcaggcatctttacatttgag
gaacccgtgactcacgtgagcgagagcattggcatcatggaggtgaaggttttgagaacc
tctggagctcgaggaaatgttatcattccctacaaaactattgaaggcacagcccgaggt
ggaggggaagactttgaggacacctgtggagagctcgaattccagaacgatgaaatagtc
aaaacaatatcagtcaaggtaatcgatgacgaggagtatgagaaaaacaagaccttcttc
attgagattggagagccccgtctggtggagatgagtgagaagaaagccctgttgttgaat
gagcttggtggcttcacattaacaggaaaagagatgtatggccaacctatcttcaggaag
gtccatgctagagatcatccgattccctctactgtaatcaccatctcagaggaatatgat
gacaagcagccactgaccagcaaagaagaggaggagaggcgcattgcggaaatggggcgc
cccatcctaggcgagcacaccaagctggaggtgatcatcgaagagtcttacgaattcaag
agcactgtggacaaactcattaagaagacgaacctggcccttgtggtggggaccaacagc
tggagagagcagtttatcgaagccatcactgtcagcgctggggaagatgacgatgatgat
gaatgtggggaggagaagctgccctcctgttttgattacgtgatgcactttctcacagtg
ttctggaaggttctgtttgccttcgtcccacctacagaatactggaatggctgggcctgc
ttcattgtctccatcctcatgatcggcctactgaccgccttcattggagacctggcttcc
cactttggctgcaccattggtctgaaagattccgtgactgccgttgtgtttgttgctctt
ggaacctcggtgccagacacatttgccagcaaagtagcagctacccaggaccagtatgca
gatgcgtctataggcaatgtcactggaagcaatgctgtgaatgtcttcctgggaatcggc
gtggcctggtccattgctgccatctaccatgcggccaacggggaacagttcaaagtgtcc
cccggcacgctagctttctctgtcactctcttcactatttttgctttcatcaacgtgggg
gtgctgctgtatcggcggaggccagaaataggaggtgagctgggagggccccggactgcc
aagctcctcacatcttccctgtttgtgctcctgtggctcttgtacattttcttctcctcc
ctggaagcctactgccacataaagggcttctaa

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