KEGG   Mus musculus (mouse): 20848Help
Entry
20848             CDS       T01002                                 

Gene name
Stat3, 1110034C02Rik, AW109958, Aprf
Definition
(RefSeq) signal transducer and activator of transcription 3
  KO
K04692  signal transducer and activator of transcription 3
Organism
mmu  Mus musculus (mouse)
Pathway
mmu01521  EGFR tyrosine kinase inhibitor resistance
mmu04062  Chemokine signaling pathway
mmu04066  HIF-1 signaling pathway
mmu04068  FoxO signaling pathway
mmu04217  Necroptosis
mmu04550  Signaling pathways regulating pluripotency of stem cells
mmu04630  Jak-STAT signaling pathway
mmu04659  Th17 cell differentiation
mmu04917  Prolactin signaling pathway
mmu04920  Adipocytokine signaling pathway
mmu04931  Insulin resistance
mmu04933  AGE-RAGE signaling pathway in diabetic complications
mmu05145  Toxoplasmosis
mmu05160  Hepatitis C
mmu05161  Hepatitis B
mmu05162  Measles
mmu05163  Human cytomegalovirus infection
mmu05167  Kaposi sarcoma-associated herpesvirus infection
mmu05169  Epstein-Barr virus infection
mmu05200  Pathways in cancer
mmu05203  Viral carcinogenesis
mmu05205  Proteoglycans in cancer
mmu05206  MicroRNAs in cancer
mmu05212  Pancreatic cancer
mmu05221  Acute myeloid leukemia
mmu05223  Non-small cell lung cancer
mmu05321  Inflammatory bowel disease (IBD)
Module
mmu_M00684  JAK-STAT signaling
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 Jak-STAT signaling pathway
    20848 (Stat3)
   04066 HIF-1 signaling pathway
    20848 (Stat3)
   04068 FoxO signaling pathway
    20848 (Stat3)
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    20848 (Stat3)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    20848 (Stat3)
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    20848 (Stat3)
   04062 Chemokine signaling pathway
    20848 (Stat3)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    20848 (Stat3)
   04917 Prolactin signaling pathway
    20848 (Stat3)
 09160 Human Diseases
  09161 Cancers: Overview
   05200 Pathways in cancer
    20848 (Stat3)
   05206 MicroRNAs in cancer
    20848 (Stat3)
   05205 Proteoglycans in cancer
    20848 (Stat3)
   05203 Viral carcinogenesis
    20848 (Stat3)
  09162 Cancers: Specific types
   05212 Pancreatic cancer
    20848 (Stat3)
   05221 Acute myeloid leukemia
    20848 (Stat3)
   05223 Non-small cell lung cancer
    20848 (Stat3)
  09163 Immune diseases
   05321 Inflammatory bowel disease (IBD)
    20848 (Stat3)
  09167 Endocrine and metabolic diseases
   04931 Insulin resistance
    20848 (Stat3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    20848 (Stat3)
  09172 Infectious diseases: Viral
   05162 Measles
    20848 (Stat3)
   05161 Hepatitis B
    20848 (Stat3)
   05160 Hepatitis C
    20848 (Stat3)
   05163 Human cytomegalovirus infection
    20848 (Stat3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    20848 (Stat3)
   05169 Epstein-Barr virus infection
    20848 (Stat3)
  09174 Infectious diseases: Parasitic
   05145 Toxoplasmosis
    20848 (Stat3)
  09176 Drug resistance: Antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    20848 (Stat3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:mmu03000]
    20848 (Stat3)
Transcription factors [BR:mmu03000]
 Eukaryotic Type
  beta-Scaffold factors with minor groove contacts
   STAT
    20848 (Stat3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: STAT_bind STAT_alpha STAT_int SH2 E2R135 Syntaxin-6_N Fib_alpha
Motif
Other DBs
NCBI-GeneID: 20848
NCBI-ProteinID: NP_998824
MGI: 103038
Ensembl: ENSMUSG00000004040
Vega: OTTMUSG00000002128
UniProt: P42227 Q3ULI4
Structure
PDB: 

Position
11 D; 11 63.82 cM
AA seq 770 aa AA seqDB search
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM
NT seq 2313 nt NT seq  +upstreamnt  +downstreamnt
atggctcagtggaaccagctgcagcagctggacacacgctacctggagcagctgcaccag
ctgtacagcgacagcttccccatggagctgcggcagttcctggcaccttggattgagagt
caagactgggcatatgcagccagcaaagagtcacatgccacgttggtgtttcataatctc
ttgggtgaaattgaccagcaatatagccgattcctgcaagagtccaatgtcctctatcag
cacaaccttcgaagaatcaagcagtttctgcagagcaggtatcttgagaagccaatggaa
attgcccggatcgtggcccgatgcctgtgggaagagtctcgcctcctccagacggcagcc
acggcagcccagcaagggggccaggccaaccacccaacagccgccgtagtgacagagaag
cagcagatgttggagcagcatcttcaggatgtccggaagcgagtgcaggatctagaacag
aaaatgaaggtggtggagaacctccaggacgactttgatttcaactacaaaaccctcaag
agccaaggagacatgcaggatctgaatggaaacaaccagtctgtgaccagacagaagatg
cagcagctggaacagatgctcacagccctggaccagatgcggagaagcattgtgagtgag
ctggcggggctcttgtcagcaatggagtacgtgcagaagacactgactgatgaagagctg
gctgactggaagaggcggcagcagatcgcgtgcatcggaggccctcccaacatctgcctg
gaccgtctggaaaactggataacttcattagcagaatctcaacttcagacccgccaacaa
attaagaaactggaggagctgcagcagaaagtgtcctacaagggcgaccctatcgtgcag
caccggcccatgctggaggagaggatcgtggagctgttcagaaacttaatgaagagtgcc
ttcgtggtggagcggcagccctgcatgcccatgcacccggaccggcccttagtcatcaag
actggtgtccagtttaccacgaaagtcaggttgctggtcaaatttcctgagttgaattat
cagcttaaaattaaagtgtgcattgataaagactctggggatgttgctgccctcagaggg
tctcggaaatttaacattctgggcacgaacacaaaagtgatgaacatggaggagtctaac
aacggcagcctgtctgcagagttcaagcacctgacccttagggagcagagatgtgggaat
ggaggccgtgccaattgtgatgcctccttgatcgtgactgaggagctgcacctgatcacc
ttcgagactgaggtgtaccaccaaggcctcaagattgacctagagacccactccttgcca
gttgtggtgatctccaacatctgtcagatgccaaatgcttgggcatcaatcctgtggtat
aacatgctgaccaataaccccaagaacgtgaacttcttcactaagccgccaattggaacc
tgggaccaagtggccgaggtgctcagctggcagttctcgtccaccaccaagcgggggctg
agcatcgagcagctgacaacgctggctgagaagctcctagggcctggtgtgaactactca
gggtgtcagatcacatgggctaaattctgcaaagaaaacatggctggcaagggcttctcc
ttctgggtctggctagacaatatcatcgaccttgtgaaaaagtatatcttggccctttgg
aatgaagggtacatcatgggtttcatcagcaaggagcgggagcgggccatcctaagcaca
aagcccccgggcaccttcctactgcgcttcagcgagagcagcaaagaaggaggggtcact
ttcacttgggtggaaaaggacatcagtggcaagacccagatccagtctgtagagccatac
accaagcagcagctgaacaacatgtcatttgctgaaatcatcatgggctataagatcatg
gatgcgaccaacatcctggtgtctccacttgtctacctctaccccgacattcccaaggag
gaggcatttggaaagtactgtaggcccgagagccaggagcaccccgaagccgacccaggt
agtgctgccccgtacctgaagaccaagttcatctgtgtgacaccaacgacctgcagcaat
accattgacctgccgatgtccccccgcactttagattcattgatgcagtttggaaataac
ggtgaaggtgctgagccctcagcaggagggcagtttgagtcgctcacgtttgacatggat
ctgacctcggagtgtgctacctcccccatgtga

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