KEGG   Mus musculus (house mouse): 214585
Entry
214585            CDS       T01002                                 
Symbol
Spg11, 6030465E24Rik, A330015I11, C530005A01Rik
Name
(RefSeq) SPG11, spatacsin vesicle trafficking associated
  KO
K19026  spatacsin
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu05014  Amyotrophic lateral sclerosis
mmu05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    214585 (Spg11)
   05022 Pathways of neurodegeneration - multiple diseases
    214585 (Spg11)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins [BR:mmu03400]
    214585 (Spg11)
DNA repair and recombination proteins [BR:mmu03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    Other HR factors
     214585 (Spg11)
SSDB
Motif
Pfam: Spatacsin_C
Other DBs
NCBI-GeneID: 214585
NCBI-ProteinID: NP_663506
MGI: 2444989
Ensembl: ENSMUSG00000033396
UniProt: Q3UHA3
Position
2:complement(121884001..121949915)
AA seq 2430 aa
MAAQPGPGSAASPGCAGAMERVLPMLLVRIPAEETAQLGPRAQLHRELEALGSLTAAGSL
QVLSLAPGSRGGSSCCLPGPFRQFLWEESQNSTSRDRPKLLVAREDYELLVYEFDLRDGR
CDAALLHGCCGRTLQKLTEDQGVSISFKSLRILSFHNNTSLLLINRCLILRVVFPGKEPG
VPVLDCLSLPLPAQAADMIIDAQLCERFLFVLSTVGLIYIFNTMDGTQVAQVDLALLRED
SEQLEPASVSSFTSLRVSQDLDVLVLVSSASTAVALNLHLYFRQHPGHLLCEGTLEDLPI
EGPPGIDEDDLVNSAHNMKLSKVSFQVDRSWRAQLLSLNESVRGSEPEVSCCAPWFQSAL
RLESLESADHTPTVPTHVFIPGDVPRGRCAFPQKEHVKSSDPGRPWKTMHLSEHEQPTEL
TCLSVTGFTALFTWAVGATSCTIGLWDLETQSMQCFSLSQKCTPVDIGGDQQLCLALTDD
GLSLILFGLTQEEFLNRLMIHGSASTVDSLCHLNGWGRCSIPIHALEAGIENRQLDTVDF
FLKSKENLLTPSSQSPAPDQQHPFSSHLYLRQVEEMSPALDLLCSAIRESDSETQSKHFA
EQLLHLTLSFLNKQIRELCVHTEELDEHFQKGVAILTSYINELRTFMIKFPWKPGDAIDE
SDVNEGVVTVKEDRVWEELSFEEVIADAILNNRIPEAQTFFRISGHSAQRLEELVRIGLD
LAFDSLKKNNVEEASRLLRNMGFSVEDELLKICFYTTDKNIRDFLVEILKEKECFSEKER
RTVDFVHQLEALYSGHFQENAQTQAFPRYWIKEQDCFKHKSVLDTFLKYDKKDEFHKQDH
RIALNWAHRWDLQTQECILLRRLSPEEYKARSPEALWRHLTARHDCSSISLWMEEFQTQE
TESPQQSKWPPLSADIIEQGTCCHSHMRNEILDKLARSGIFLASELEDFERLLLRLSRIG
GVMQDSLPVQSYKSRAGCDFHSRFILYCLEHGLQHLLYTYLDYYKLSPGNCPFLEKKELH
EAHPWLEFLVQCRQVSSNLTDPKLIFQASLANAQILIPTNQASVSSMLLEGHTLLALATT
MYAPGGVSQVIQNEDSENCLKKVDPQLLKVALTPYPKLKAALFPQYTAPSILPSDITLYH
LIQSLPPFDPSRLFVWQSANTLAIGDTGSQLPHFSSPDLVSKYAVLERLNYAYYLHHGRP
SFAFGTFLVQELIKSKTPKQLIQQVGKEAYTLGLSSFTNPSVGAACVCFLELLGLSSLKL
RVDLKMANVILGSKRRDEDARSSFIRESLAEKLSKLADGDRAATEELLVLLEEGVWDSIE
QQGFSRLSSESSSQWALVLQFCMLHDRKLSVSYLRECAKANDWLQFLVHSQLHNYHPAEV
ESLLQYFSPVLQSHLKLASEKLSSGSISRDDSCLQELQKNKGETSNFFEILHRCSDESTS
WSWLLAEAVRHRAPILSVLASCVQGASVVSCLCVWIVTSVEDKVAAEAMGHIQISVEDHH
WSLKDLSIIWRTVLTRRKSHTLIRGFQLFIKDSPLLLIMEMYELCMFFKNYEKAKVKLLE
FQKSLETLDTVAARVLPIIPASWMKDQVCFLLKLMPQQCETQYELGKLLQLFVGTEQLFS
DGPDVQKLCLLSQVLKDTPIAISPAVISSYSTENFQRECRSILEKLKADGQFAVARRVAE
LAALPVDSLLIEQLTQEMQTLTHTPQWSLKQERLGFWKKCHEIFKKNSISKRAASSFFSS
QAPEVSEHPAEQGSLEERHLLLTLAGHWLAQEEPVPVEELEGLEKQIWICRVAQHTCGGA
EEEAKPSLSQHKLAAAELSFDSLASELSFSKLAALNTSKYLGLNDLPSKTTCENRLKHKE
QESLNTLIGQLLDGGCVHEASRVCQYFRFYSQDLVLVLHCRALASAEATMEDLHSEIRAL
LSSAAQPEDLESPSVPLRKAHSSSSLDSQSFVMVPPTDEVAQNLHTLISKCLHGKNYCRQ
VLCLYELAKDLGCSYGDVAARDSEAMLRAILASQRPDRCRQAQVFINTQGLEADTVAELV
AEEVTRELLTPSEGTGEKQPFNPAEESQTFLQLTALCQDRTLVGMKLLDKIPSVPHGELS
CTTELLILAHHCFTFTCHMEGITRVLQAARMLTDNHLAPNEEYGLVVRLLTGIGRYNEMT
YIFDLLHQKHYFEVLMRKKLDPTGTLKTALLDYIKRCRPGDSEKHNMIALCFSMCREIGE
NHEAAACIQLKLIESQPWEESLKDGAQLKQLLLKALTLMLDAAESYAKDSCVRQALHCNR
LTKLITLQIHFLNSGQNTMLINLGHQKLMDCIMTLPRFYQASIVAEAYDFVPDWAEVLYQ
QVILKGDFSYLEEFKQQKLLRPNIFEDISKKYKQHQPTDRVTENLKKLLSYCEDIYLYYK
LAYEHKFFEIVNMLLKDPQTGCCLKDMLAG
NT seq 7293 nt   +upstreamnt  +downstreamnt
atggctgcccagccagggcccggaagtgctgcctcccccggctgtgccggggccatggag
cgggtcctgcccatgctgctggtgcggatcccagctgaggagacggcgcagctgggaccg
cgggcgcagctgcaccgagagctggaggccctggggagcctgacggctgcgggcagtctc
caagtgctttccttggcgccgggcagcaggggtgggagcagctgctgcctcccaggaccc
tttaggcagttcctatgggaggagtctcagaacagcacatcaagagacaggcccaagctg
cttgttgccagagaagattatgagctgctcgtatatgaatttgacttgagagatggaaga
tgtgacgcagccttattacacggctgttgtgggaggacactgcagaagctcactgaagat
caaggtgtcagtatttccttcaagtctttgagaattctgtcatttcacaacaacacgtca
ttactgctcatcaacagatgtctcatcctacgcgttgtgtttccggggaaagaacctggg
gtcccagtgctggactgcctctcactgcccctgcctgcacaggcagcggacatgatcatt
gatgcacagctctgtgagagatttctttttgttctgagcacagtgggcttgatctatatt
tttaacactatggatggcacgcaggtagcgcaagtggacctggctcttctcagagaagat
tctgagcagctggagcccgccagtgtctcttcctttacatcgctgagagtgtctcaggac
ttggatgttctggtgctggtcagctcagccagtactgcagttgctcttaacctacatttg
tatttcaggcaacatccgggacacctactgtgtgaaggaacactggaagaccttcctatt
gaagggcctccagggatagatgaagacgacctggttaactctgcccacaacatgaaactg
agcaaggtgtcctttcaagttgataggtcctggagagcccagctgttgtcactgaatgaa
tcagtgaggggctcggaaccagaggtttcctgctgtgctccgtggttccagagtgctttg
cgtttggagtccctggaatctgctgaccacacccccactgtgccaacccacgttttcatt
cccggggatgtcccacgtggccggtgtgcttttcctcagaaggagcacgtgaagagcagt
gatccaggaaggccgtggaagacaatgcacctgagtgaacatgagcagcccacggagctc
acgtgcctgtctgtgacgggatttactgcactgtttacctgggcagtaggagcgaccagc
tgcaccatcggcctctgggacttggagacccagagcatgcagtgtttttctctcagccag
aagtgtactcctgtagacattggcggagaccagcagctgtgccttgctttgacagatgat
ggtctgtctctgattttgtttggtttaacccaagaggagtttttgaacagactaatgatc
cacggcagcgccagcactgtggactccctttgtcatctcaacggttggggacggtgctca
atccctatccacgctctagaggctggcatagaaaatcgtcagctggacacagtagatttc
ttcttgaagagcaaggaaaatcttcttactccgtcttcacaatctcctgctcctgatcag
cagcatcccttttcatcccatctgtacctaagacaggtagaagagatgagcccagccctg
gatttactatgctcagcaattagagaaagtgactcggaaacccaaagcaaacactttgct
gagcagctgcttcacctcacactgtccttccttaacaaacagataagggagctttgtgtt
cacactgaagagctagatgagcattttcagaaaggagtggccattttgaccagctacatc
aatgagcttcggacttttatgataaagtttccttggaaaccaggagatgccatagatgaa
tctgatgtaaatgaaggtgtcgtcacagtgaaggaggaccgggtttgggaggaactcagc
tttgaggaagttattgctgatgccattttaaataacagaataccagaggcacaaactttc
tttaggattagtggtcattccgctcaacgactggaggaactggttaggatcggcctagat
ctggcatttgacagtttaaaaaagaacaacgtggaggaggcctcgaggctcctgaggaac
atgggcttcagtgtggaagatgagttgcttaagatatgcttttatacaactgataaaaat
atacgggactttttggttgaaattttaaaagaaaaggaatgtttttctgaaaaagaaaga
agaactgtagactttgttcatcaacttgaagcactttattctggacacttccaggaaaat
gcacagacgcaggctttccccaggtattggataaaggaacaggactgtttcaaacacaaa
tctgtcttggacacattcctcaaatatgataaaaaagatgagtttcacaaacaggaccat
agaattgcattgaattgggctcaccggtgggatctccaaacacaggaatgtatccttctc
cgcagactaagtccagaagaatacaaagcgcgctccccggaagccctgtggagacacctc
acggctcgccatgactgctcaagcatcagcttgtggatggaagaatttcagacccaggaa
accgagtcacctcagcagagcaagtggccccctctgagtgctgacatcattgagcagggc
acttgctgccacagtcacatgaggaatgagattttagacaagctggccagaagtggcatt
tttcttgcatctgagctggaagactttgaacgtctcctcctgaggctgagccggattggg
ggcgtaatgcaggacagcctccccgtgcagagctacaaatcccgtgcagggtgtgacttt
cattcccggttcatcctctactgtttagagcacggcctacagcatcttctctacacctat
cttgactattacaaacttagtcctggaaattgtccttttttggaaaagaaagaactacat
gaagctcacccttggcttgaatttttggttcaatgtcggcaagtctccagtaacttgaca
gatcccaaactcatctttcaggctagccttgcaaatgctcagattttgattcccaccaat
caggccagtgtgagcagtatgctgttggaaggacacaccctcctggcccttgctaccacc
atgtatgctccagggggtgtcagccaggtcattcagaatgaagacagcgagaactgtttg
aagaaagtggacccccagctactgaaggtggctttaacaccttacccaaagctcaaagct
gcgctcttcccacagtacactgctcctagtattctgccctctgatattacactctaccac
ctcatccagtccttgccgccctttgatcctagccggctgttcgtctggcagtctgccaac
acactagctataggagacacaggcagtcagctcccacacttttccagccctgacctggtg
agtaaatacgctgtgctggaacggctgaactacgcgtattatctacatcacggacgcccg
tcgtttgcctttggcacctttctggtccaggagttgatcaagagtaagactcccaaacaa
ctgatccagcaagtaggcaaggaggcctataccttagggctctcttccttcaccaaccct
tcggtaggggctgcctgtgtctgcttcttagaattgcttggcctcagcagcctcaagctc
agagttgacctgaaaatggcaaatgtaattttgggctccaagcgtagagatgaagatgct
cgttccagcttcatcagagagtctctggctgagaagctgtctaagcttgctgacggtgac
agagcagccacagaagagctgcttgttctcttggaggaaggcgtgtgggacagcattgag
cagcagggctttagcaggttgtccagtgagtccagcagccagtgggcattagtgcttcag
ttctgcatgctccatgacaggaagctgagcgtgtcctaccttagagaatgtgccaaagcc
aatgactggctgcagttcctggtccacagccagctgcataactaccacccagcagaggtg
gaatctcttcttcagtatttcagtcctgtccttcagagccacttgaagctggcttctgag
aaactgtcatcagggtccatctctagggatgacagctgcctccaggaactccagaaaaac
aaaggagaaacgagtaatttctttgaaattctccaccggtgctcagatgagtccacctct
tggagctggctcctggctgaggcagtgagacatcgggctcccatcctcagtgtcctggcc
tcgtgtgtgcagggtgccagtgttgtctcctgtctctgtgtttggattgtcacctccgtg
gaggacaaggttgcagctgaagcaatgggacacattcagatctctgtagaggaccatcac
tggagcctgaaggacctgtccatcatctggagaactgtattgacaagacgcaagagccac
actctcatccgaggtttccagctctttattaaggattccccacttctattgattatggag
atgtatgaactgtgtatgttcttcaagaattacgagaaagccaaagttaaacttttggag
ttccagaaaagccttgaaacacttgacacagtggccgcaagggtccttcctatcatacct
gcctcgtggatgaaagaccaggtttgtttccttttgaaacttatgccgcagcagtgtgag
acgcagtatgagctggggaaactcctccaactgtttgttggcactgagcagctcttctct
gacgggccagacgtgcagaagctgtgtctcctcagccaagtgctgaaggacacacctatc
gccattagccctgcagtcatttccagctacagcactgagaactttcagcgggaatgtaga
tctattttggagaagctaaaagcagatgggcagtttgctgtggctaggagagtggccgag
ttagcagccctgcctgtggacagcttgctgattgaacagttaactcaggaaatgcaaaca
ctaacacacactccgcagtggtccctgaaacaagaaagacttggcttctggaaaaaatgc
catgaaatttttaagaaaaactctatttcaaagagagcagcctcttccttcttctctagc
caagcccccgaggtgagtgagcaccctgctgaacagggcagccttgaggagcgccatctg
ctgctcactctggctggccactggcttgcccaagaagagccggttcccgtggaggaactg
gaggggctggagaaacagatttggatctgccgcgtcgcccagcacacatgtggaggggct
gaagaggaagccaagcccagcctctctcaacacaagttggctgctgctgaactttctttt
gatagcttagccagtgagctgtccttctccaagctcgctgctttgaacacatccaaatac
ttaggccttaatgatcttccatccaagacgacgtgtgagaacagactgaaacacaaagag
caggagtcactgaacactttgatcgggcagctgctggatggtggctgtgtgcatgaagca
agcagagtgtgccagtatttccgtttctatagccaggatctagtgctggtgttgcactgc
agagccttggcctccgcagaagccaccatggaagacttgcactcagagatccgtgccctc
ctctcaagtgccgcacagcctgaggacctggagagcccgagtgtccctcttcggaaagcc
catagctcttcaagtttggacagtcagtcatttgtgatggtaccacccactgatgaggta
gcccagaacctccacactctcataagcaagtgcctccatgggaagaactactgccggcag
gtcctctgtctgtatgaacttgccaaggatttgggctgttcctatggagatgttgctgct
agggacagtgaagccatgctccgagcaatcttggcttctcagcggcctgaccgatgtaga
caagcccaggtcttcatcaacacccagggccttgaagcagacactgtggctgaactagtg
gctgaagaggtgacacgggagctactgactccatcagagggaacaggagaaaagcaacct
ttcaacccagcagaggaaagccagacatttcttcagctaactgctttgtgtcaagaccgt
acattggtaggcatgaagttgttggacaagattccctctgtcccccacggggagctgtct
tgcaccacagagctcctgatcctggcccaccactgctttaccttcacgtgccacatggaa
ggcatcaccagagtcctgcaagccgcccgcatgctcacagataaccacttggctcccaat
gaggagtacggattagtggtccgcctcctcactggcatcgggcgctacaatgagatgacg
tacatatttgacttgctgcatcaaaagcattatttcgaagttctgatgagaaagaagcta
gacccaaccggcaccctgaagacagccctactagactacatcaaacgttgccgccctgga
gacagcgaaaagcacaatatgattgccctgtgcttcagtatgtgccgggagataggagag
aatcacgaggcagcagcctgcatccaactgaagctgattgagtctcagccctgggaggaa
agcctcaaggatggagcccaactaaaacagctcctgcttaaagccctgactctgatgttg
gatgcagcagagagttacgccaaggactcctgtgttcgacaggccctgcactgtaaccgg
ctcaccaagttgataacactacagattcactttctcaacagtggccagaatacaatgctt
atcaacttgggccatcagaagctaatggactgtatcatgaccctacctcggttctaccag
gcttctattgtagctgaggcctatgactttgttcctgactgggctgaagtactctaccaa
caagtgattcttaaaggagactttagttatttggaagaatttaagcagcagaagttacta
agacccaatatatttgaagacatttccaaaaaatataaacaacaccagcctaccgacagg
gtcacagaaaacctgaagaagttactttcatattgtgaagatatctacctgtattacaag
ttggcatatgaacacaaattttttgaaattgtaaatatgcttctgaaggaccctcagacg
ggatgctgccttaaagatatgctcgcaggttag

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (66)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (60)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (25)   
   RefSeq(nuc) (7)   
   GenBank (9)   
   EMBL (9)   
Protein domain (1)   
   Pfam (1)   
All databases (102)   

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