KEGG   Mus musculus (mouse): 216148
Entry
216148            CDS       T01002                                 

Gene name
Shc2, 6720466E06, SCK, Shc, ShcB, Sli
Definition
(RefSeq) SHC (Src homology 2 domain containing) transforming protein 2
  KO
K17447  SHC-transforming protein 2
Organism
mmu  Mus musculus (mouse)
Pathway
mmu01521  EGFR tyrosine kinase inhibitor resistance
mmu01522  Endocrine resistance
mmu04012  ErbB signaling pathway
mmu04014  Ras signaling pathway
mmu04062  Chemokine signaling pathway
mmu04072  Phospholipase D signaling pathway
mmu04370  VEGF signaling pathway
mmu04510  Focal adhesion
mmu04650  Natural killer cell mediated cytotoxicity
mmu04722  Neurotrophin signaling pathway
mmu04910  Insulin signaling pathway
mmu04915  Estrogen signaling pathway
mmu04917  Prolactin signaling pathway
mmu04926  Relaxin signaling pathway
mmu04935  Growth hormone synthesis, secretion and action
mmu05034  Alcoholism
mmu05100  Bacterial invasion of epithelial cells
mmu05214  Glioma
mmu05220  Chronic myeloid leukemia
mmu05224  Breast cancer
mmu05225  Hepatocellular carcinoma
mmu05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    216148 (Shc2)
   04014 Ras signaling pathway
    216148 (Shc2)
   04370 VEGF signaling pathway
    216148 (Shc2)
   04072 Phospholipase D signaling pathway
    216148 (Shc2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    216148 (Shc2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    216148 (Shc2)
   04062 Chemokine signaling pathway
    216148 (Shc2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    216148 (Shc2)
   04915 Estrogen signaling pathway
    216148 (Shc2)
   04917 Prolactin signaling pathway
    216148 (Shc2)
   04926 Relaxin signaling pathway
    216148 (Shc2)
   04935 Growth hormone synthesis, secretion and action
    216148 (Shc2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    216148 (Shc2)
 09160 Human Diseases
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    216148 (Shc2)
   05226 Gastric cancer
    216148 (Shc2)
   05214 Glioma
    216148 (Shc2)
   05220 Chronic myeloid leukemia
    216148 (Shc2)
   05224 Breast cancer
    216148 (Shc2)
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    216148 (Shc2)
  09165 Substance dependence
   05034 Alcoholism
    216148 (Shc2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    216148 (Shc2)
   01522 Endocrine resistance
    216148 (Shc2)
SSDB
Motif
Pfam: PID SH2
Other DBs
NCBI-GeneID: 216148
NCBI-ProteinID: NP_001019710
MGI: 106180
Ensembl: ENSMUSG00000020312
UniProt: Q8BMC3
Position
10 C1; 10 39.72 cM
AA seq 573 aa
MTQGPGGRAAPEPEAPTTFCALLPRMPQWKFAAPGSFLGRGPAATRVAGVAEAQPEPGVP
ALAAVLGACEPRCAAPCPLPALGRCRGSGTRGARVTPDVADEWVRKGGFIHKPAHGWLHP
DARVLGPGVSYIVRYMGCIEVLRSMRSLDFNTRTQVTREAINRLHEAVPGVRGSWKKKAP
NKALASILGKSNLRFAGMSISVNISVDGLNLSVPATRQIIANHHMQSISFASGGDTDMTD
YVAYVAKDPINQRACHILECCEGLAQSVISTVGQAFELRFKQYLHSPPKAVVPPERLTGL
EELAWGDDDAAADHNYYNSIPGKEPPLGGLVDSRLAVTQPCALATLGGLGQGMTPVWRDA
RGLPWDMGPSGAAPPGDGYVQADARGPHDYEEHLYVNTQGLDAVELEDTAEAPLQFEDSP
KKDLFDMRPFEDALKLHACSVAAGITAASPPLEDQWPSPPTRRAPIAPTEEQLRQEPWYH
GRMSRRAAEKLLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGVVRTKDVLFE
SISHLIDYHLKNGLPIVAAESELHLRGVVSREP
NT seq 1722 nt   +upstreamnt  +downstreamnt
atgacgcagggtccgggtggccgcgcggcccccgagcccgaggcgcccaccaccttctgc
gcactgctgccgcggatgccgcagtggaagttcgcagcgccgggtagcttcctgggccgc
ggtcccgcggcgacgcgcgtggcgggggtggcagaggcgcagccggagcccggggtcccc
gcgctggccgctgtgttgggcgcttgcgaaccgcgctgcgccgcgccctgtccgctgccc
gcgctcggccgctgccggggctcggggacgcggggcgcgcgggtgactccggatgtcgct
gacgagtgggtgcgcaagggcggcttcattcacaagccggcgcacggctggttgcatccc
gatgccagggtcctggggcccggggtctcttacatcgttcggtacatgggctgcattgag
gtgcttcgatccatgcgctccctggatttcaacacccgaacacaggtgacgagggaagcc
atcaatcggctccatgaggctgtgcccggtgtccggggctcctggaagaagaaggccccc
aacaaggctctggcctccatcttggggaaaagcaacctgcgcttcgccggcatgagcatc
tcagtcaacatctccgtggacggccttaacttgtctgttcccgccacccgccagatcatc
gccaaccatcatatgcagtctatttccttcgcctcgggtggtgacacggacatgactgat
tacgtggcctatgtggccaaggaccccatcaaccagagagcctgccacatcttggaatgc
tgtgaaggtcttgcccagagcgtcatcagcaccgtagggcaagcctttgagctgcgcttc
aagcaatacctgcacagtccgcccaaggcggtagtgccccctgaaaggctgactgggctg
gaggagttggcctggggagatgatgacgctgctgcagaccacaattactacaacagcatt
ccgggaaaggagccacccctgggcgggctggtggactccagactggctgtcacacagccc
tgtgcgctggcgacactcgggggccttggacagggaatgacaccagtatggagagatgcc
cgtggcttgccttgggacatgggcccctctggagcagccccaccgggggatggctacgtg
caggcagatgcccgagggccacatgactacgaggagcacctgtatgtcaatacccagggc
ctggatgctgtggagcttgaggacaccgccgaggcacctctgcagtttgaggacagcccc
aagaaggacctgtttgacatgcgaccctttgaagatgccctgaagttgcacgcgtgctca
gtggcagccggcatcactgcagcctcaccccctctggaagaccagtggcccagtccccct
acccgcagggcccccattgcacccacagaggagcaattgaggcaggagccctggtaccac
ggacgaatgagccgtcgggctgcagagaagctgcttcgggccgatggggacttccttgtg
agagacagcgtcaccaacccggggcagtatgtcctcacgggcatgcatgcggggcagccc
aagcacctgctgctggtggaccccgagggtgtggtgcggacgaaagatgtgttgtttgag
agcatcagccacctcatagactatcacctgaagaatgggctgcctatcgtggctgctgag
agcgagctgcatctgcggggagtggtctctcgggagccatga

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