KEGG   Mus musculus (house mouse): 21813
Entry
21813             CDS       T01002                                 
Symbol
Tgfbr2, 1110020H15Rik, DNIIR, RIIDN, TBR-II, TbetaR-II, TbetaRII
Name
(RefSeq) transforming growth factor, beta receptor II
  KO
K04388  TGF-beta receptor type-2 [EC:2.7.11.30]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04010  MAPK signaling pathway
mmu04060  Cytokine-cytokine receptor interaction
mmu04068  FoxO signaling pathway
mmu04144  Endocytosis
mmu04218  Cellular senescence
mmu04350  TGF-beta signaling pathway
mmu04380  Osteoclast differentiation
mmu04390  Hippo signaling pathway
mmu04520  Adherens junction
mmu04659  Th17 cell differentiation
mmu04926  Relaxin signaling pathway
mmu04933  AGE-RAGE signaling pathway in diabetic complications
mmu05142  Chagas disease
mmu05161  Hepatitis B
mmu05166  Human T-cell leukemia virus 1 infection
mmu05200  Pathways in cancer
mmu05202  Transcriptional misregulation in cancer
mmu05210  Colorectal cancer
mmu05212  Pancreatic cancer
mmu05220  Chronic myeloid leukemia
mmu05225  Hepatocellular carcinoma
mmu05226  Gastric cancer
mmu05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    21813 (Tgfbr2)
   04390 Hippo signaling pathway
    21813 (Tgfbr2)
   04068 FoxO signaling pathway
    21813 (Tgfbr2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    21813 (Tgfbr2)
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    21813 (Tgfbr2)
  09152 Endocrine system
   04926 Relaxin signaling pathway
    21813 (Tgfbr2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    21813 (Tgfbr2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    21813 (Tgfbr2)
   05202 Transcriptional misregulation in cancer
    21813 (Tgfbr2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    21813 (Tgfbr2)
   05212 Pancreatic cancer
    21813 (Tgfbr2)
   05225 Hepatocellular carcinoma
    21813 (Tgfbr2)
   05226 Gastric cancer
    21813 (Tgfbr2)
   05220 Chronic myeloid leukemia
    21813 (Tgfbr2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    21813 (Tgfbr2)
   05161 Hepatitis B
    21813 (Tgfbr2)
  09174 Infectious disease: parasitic
   05142 Chagas disease
    21813 (Tgfbr2)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    21813 (Tgfbr2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    21813 (Tgfbr2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    21813 (Tgfbr2)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.30  receptor protein serine/threonine kinase
     21813 (Tgfbr2)
Protein kinases [BR:mmu01001]
 Receptor serine/threonine kinases (RSTK): TKL group
  TGFBR2 family [OT]
   21813 (Tgfbr2)
SSDB
Motif
Pfam: ecTbetaR2 PK_Tyr_Ser-Thr Pkinase ABC1 Haspin_kinase Pkinase_fungal APH
Other DBs
NCBI-GeneID: 21813
NCBI-ProteinID: NP_083851
MGI: 98729
Ensembl: ENSMUSG00000032440
UniProt: Q62312 Q543C0 Q8BQS9 Q3UG22
Position
9:complement(115916763..116004431)
AA seq 567 aa
MGRGLLRGLWPLHIVLWTRIASTIPPHVPKSVNSDVMASDNGGAVKLPQLCKFCDVRLST
CDNQKSCMSNCSITAICEKPHEVCVAVWRKNDKNITLETVCHDPKLTYHGFTLEDAASPK
CVMKEKKRAGETFFMCACNMEECNDYIIFSEEYTTSSPDLLLVIIQVTGVSLLPPLGIAI
AVIIIFYCYRVHRQQKLSPSWESSKPRKLMDFSDNCAIILEDDRSDISSTCANNINHNTE
LLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYSSWKTEKDIFSDINLK
HENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAH
LHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVG
TARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVRE
HPCVESMKDSVLRDRGRPEIPSFWLNHQGIQIVCETLTECWDHDPEARLTAQCVAERFSE
LEHPERLSGRSCSQEKIPEDGSLNTTK
NT seq 1704 nt   +upstreamnt  +downstreamnt
atgggtcgggggctgctccggggcctgtggccgctgcatatcgtcctgtggacgcgcatc
gccagcacgatcccgccgcacgttcccaagtcggttaacagtgatgtcatggccagcgac
aatggcggtgcggtcaagcttccacagctgtgcaagttttgcgatgtgagactgtccact
tgcgacaaccagaagtcctgcatgagcaactgcagcatcacggccatctgtgagaagccg
catgaagtctgcgtggccgtgtggaggaagaacgacaagaacattactctggagacggtt
tgccacgaccccaagctcacctaccacggcttcactctggaagatgccgcttctcccaag
tgtgtcatgaaggaaaagaaaagggcgggcgagactttcttcatgtgtgcctgtaacatg
gaagagtgcaacgattacatcatcttttcggaagaatacaccaccagcagtcccgacctg
ttgttggtcattatccaagtgacgggtgtcagcctcctgcctccgctggggattgccata
gctgtcatcatcatcttctactgctaccgtgtccaccggcagcagaagctgagcccgtcc
tgggagagcagcaagccccggaaactgatggatttcagtgacaattgtgccatcatcctg
gaggacgaccgctccgacatcagctccacgtgcgccaacaacatcaaccacaacacggag
ctgctgcccatcgagctggacacgctggtggggaagggccgcttcgccgaggtctacaag
gccaagctgaagcagaacacctcagagcagtttgagaccgtggctgtcaagatcttcccc
tacgaggagtactcctcgtggaaaacagagaaggacatcttctccgatatcaacctgaag
catgagaacatcctgcagttcctgacggccgaggagcggaagacagagctgggcaagcag
tactggctgatcacggcgttccacgcgaagggcaacctgcaggagtacctcacgaggcat
gtcatcagctgggaggacctgaggaagctgggcagctccctggcccggggcatcgctcat
ctccacagtgaccacactccttgtgggaggcccaagatgcccattgttcacagggacctc
aagagctctaacatcctagtgaagaacgacttgacctgttgcctgtgtgacttcgggctg
tccttgcgcctggaccctactctgtctgtggatgacctggccaacagcgggcaggtggga
acggcaagatacatggccccggaagttctagaatccaggatgaatctggaaaacgtggag
tcgttcaagcagacggatgtctactccatggctctggtactctgggaaatgacgtcccgc
tgcaatgctgtgggagaagtgaaggattacgagcccccatttggttccaaggtgcgggag
cacccctgtgtggagagcatgaaagacagtgtgctgagagaccgagggcggccggaaatt
cccagcttctggctcaaccaccagggcatccagatcgtgtgtgagactttgaccgagtgc
tgggaccatgaccccgaagcccgtctcacagcacagtgtgtggcagagcgcttcagtgag
ctggagcatccggagagactctctgggaggagctgctcccaggagaagattccagaagat
ggctcgctgaacactaccaaatag

  All links  
Gene (10)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (7)   
   UniProt (4)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (26)   
   RefSeq(nuc) (2)   
   GenBank (12)   
   EMBL (12)   
Protein domain (7)   
   Pfam (7)   
All databases (50)   

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