KEGG   Mus musculus (house mouse): 23805
Entry
23805             CDS       T01002                                 
Symbol
Apc2, APCL
Name
(RefSeq) APC regulator of WNT signaling pathway 2
  KO
K02085  adenomatosis polyposis coli protein
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04310  Wnt signaling pathway
mmu04390  Hippo signaling pathway
mmu04550  Signaling pathways regulating pluripotency of stem cells
mmu04810  Regulation of actin cytoskeleton
mmu04934  Cushing syndrome
mmu05010  Alzheimer disease
mmu05022  Pathways of neurodegeneration - multiple diseases
mmu05165  Human papillomavirus infection
mmu05200  Pathways in cancer
mmu05206  MicroRNAs in cancer
mmu05210  Colorectal cancer
mmu05213  Endometrial cancer
mmu05217  Basal cell carcinoma
mmu05224  Breast cancer
mmu05225  Hepatocellular carcinoma
mmu05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    23805 (Apc2)
   04390 Hippo signaling pathway
    23805 (Apc2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    23805 (Apc2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    23805 (Apc2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    23805 (Apc2)
   05206 MicroRNAs in cancer
    23805 (Apc2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    23805 (Apc2)
   05225 Hepatocellular carcinoma
    23805 (Apc2)
   05226 Gastric cancer
    23805 (Apc2)
   05217 Basal cell carcinoma
    23805 (Apc2)
   05213 Endometrial cancer
    23805 (Apc2)
   05224 Breast cancer
    23805 (Apc2)
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    23805 (Apc2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    23805 (Apc2)
   05022 Pathways of neurodegeneration - multiple diseases
    23805 (Apc2)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    23805 (Apc2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:mmu01009]
    23805 (Apc2)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:mmu03036]
    23805 (Apc2)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:mmu04812]
    23805 (Apc2)
Protein phosphatases and associated proteins [BR:mmu01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     23805 (Apc2)
Chromosome and associated proteins [BR:mmu03036]
 Eukaryotic type
  Centrosome formation proteins
   Other centriole associated proteins
    23805 (Apc2)
Cytoskeleton proteins [BR:mmu04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    EB / APC
     23805 (Apc2)
SSDB
Motif
Pfam: APC_basic APC_rep APC_N_CC APC_r Arm_APC_u3 Arm Suppressor_APC SAMP bZIP_1 HALZ Sec7-like_HUS CCDC138_cc FtsL_2
Other DBs
NCBI-GeneID: 23805
NCBI-ProteinID: NP_001359166
MGI: 1346052
Ensembl: ENSMUSG00000020135
Position
10:80131790..80154091
AA seq 2303 aa
MGLLGLLSLLHSAFFGNQALQELKMTSSMASYEQLVRQVEALKAENTHLRQELRDNSSHL
SKLETETSGMKEVLKHLQGKLEQEARVLVSSGQTEVLEQLKALQTDISSLYNLKFHAPAL
GPEPAARTPEGSPVHGSGPSKDSFGELSRATIRLLEELDQERCFLLSEIEKEEKEKLWYY
SQLQGLSKRLDELPHVDTFSMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRAS
RLEQIDKELLEAQDRVQQTEPQALLAVKPVAVEEEQEAEVPTHPEDGTPQPGNSKVEVVF
WLLSMLATRDQEDTARTLLAMSSSPESCVAMRRSGCLPLLLQILHGTEAGSVGRAGIPGA
PGAKDARMRANAALHNIVFSQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDSGTES
GTGDTPVPIEPQICQATCAVMKLSFDEEYRRAMNELGGLQAVAELLQVDYEMHKMTRDPL
NLALRRYAGMTLTNLTFGDVANKATLCARRGCMEAIVAQLGSESEELHQVVSSILRNLSW
RADINSKKVLREVGSMTALMECVLRASKESTLKSVLSALWNLSAHSTENKAAICQVDGAL
GFLVSTLTYRCQGNSLAVIESGGGILRNVSSLIATREDYRQVLRDHNCLQTLLQHLTSHS
LTIVSNACGTLWNLSARSPRDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLAHR
PAKYQAAAMAVSPGTCVPSLYVRKQRALEAELDTRHLVHALGHLEKQSLPEAETTSKKPL
PPLRHLDGLVQDYASDSGCFDDDDAPSLAAAATTAEPASPAVMSMFLGGPFLQGQALART
PPARQGGLEAEKEAGGEAAVAAKAKAKLALAVARIDRLVEDISALHTSSDDSFSLSSGDP
GQEAPREGRAQSCSPCRGTEGGRREAGSRAHPLLRLKAAHTSLSNDSLNSGSTSDGYCTR
EHMTPCPLAALAEHRDDPVRGQTRPSRLDLDLPSRAELPARDTAATDARVRTIKLSPTYQ
HVPLLDGAAGAGVRPLVGPGTSPGARKQAWIPADSLSKVPEKLVASPLPIASKVLQKLVA
QDGPMSLSRCSSLSSLSSTGHAVPSQAENLDSDSSLEGLEEAGPGEAELGRAWRASGSTS
LPVSIPAPQRGRSRGLGVEDATPSSSSENCVQETPLVLSRCSSVSSLGSFESRSIASSIP
SDPCSGLGSGTVSPSELPDSPGQTMPPSRSKTPPAPPGQPETSQFSLQWESYVKRFLDIA
DCRERCQPPSELDAGSVRFTVEKPDENFSCASSLSALALHELYVQQDVELRLRPPACPER
AVGGGGHRRRDEAASRLDGPAPAGSRARSATDKELEALRECLGAAMPARLRKVASALVPG
RRSLPVPVYMLVPAPARGDDSGTDSAEGTPVNFSSAASLSDETLQGPSRDKPAGPGDRQK
PTGRAAPARQTRSHRPKAAGAGKSTEHTRGPCRNRAGLELPLSRPQSARSNRDSSCQTRT
RGDGALQSLCLTTPTEEAVYCFYDSDEEPPATAPPPRRASAIPRALKREKPAGRKETPSR
AAQPATLPVRAQPRLIVDETPPCYSLTSSASSLSEPEAPEQPANHARGPEQGSKQDSSPS
PRAEEELLQRCISLAMPRRRTQVPGSRRRKPRALRSDIRPTEITQKCQEEVAGSDPASDL
DSVEWQAIQEGANSIVTWLHQAAAKASLEASSESDSLLSLVSGVSAGSTLQPSKLRKGRK
PAAEAGGAWRPEKRGTTSTKINGSPRLPNGPEKAKGTQKMMAGESTMLRGRTVIYSAGPA
SRTQSKGISGPCTTPKKTGTSGTTQPETVTKAPSPEQQRSRSLHRPGKISELAALRHPPR
SATPPARLAKTPSSSSSQTSPASQPLPRRSPLATPTGGPLPGPGGSLVPKSPARALLAKQ
HKTQKSPVRIPFMQRPARRVPPPLARPSPEPGSRGRAGAEGTPGARGSRLGLVRMASARS
SGSESSDRSGFRRQLTFIKESPGLLRRRRSELSSADSTASTSQAASPRRGRPALPAVFLC
SSRCDELRVSPRQPLAAQRSPQAKPGLAPRAPRRTSSESPSRLPVRASPGRPETVKRYAS
LPHISVSRRSDSAVSVPTTQANATRRGSDGEARPLPRVAPPGTTWRRIKDEDVPHILRST
LPATALPLRVSSPEDSPAGTPQRKTSDAVVQTEDVATSKTNSSTSPSLESRDPPQAPASG
PVAPQGSDVDGPVLTKPPASAPFPHEGLSAVIAGFPTSRHGSPSRAARVPPFNYVPSPMA
AATMASDSAVEKAPVSSPASLLE
NT seq 6912 nt   +upstreamnt  +downstreamnt
atggggctcttgggactcctgagcctgctgcactcagccttctttgggaaccaggcactg
caggagttgaaaatgaccagctccatggcctcatatgagcagctggtgcgccaggtggag
gccctgaaggccgagaacactcacttaaggcaggagctgagggataactctagccatctc
tccaagcttgagacagagacttctggaatgaaggaggtcctgaaacacctccagggcaag
ctggagcaggaggcgagagtgctcgtgtcttccgggcagacagaagtgttagagcaactg
aaagctcttcagactgacatcagtagcctgtacaacctcaagtttcatgctccagccctg
ggcccggagcctgccgcccggactccagagggaagcccagtgcacggctctggaccatcc
aaggacagctttggagagctgagccgggccaccatccgcctgctggaagaactggaccag
gagagatgcttcctgctgagcgagatagagaaagaggagaaggagaagctatggtattac
tctcagctccagggcctgtccaagcgcttggatgagctgccgcacgtggacacgttttcg
atgcagatggatctgattcggcagcagctggagttcgaggcccagcacatccgctcgctg
atggaggagcgcttcggtacctccgacgagatggtgcagcgggcgcagatccgggcttcg
cgcttggagcagattgacaaggagctgttggaagcccaggaccgggtgcagcagacagag
cctcaggctctgctggcggtgaagcctgtggcagtagaggaggagcaggaggcagaagtc
cccacacatcctgaggatggcacccctcagcctggcaacagcaaggtggaggtggtgttc
tggcttctatctatgttggcaacgcgcgaccaggaagatactgcgcgcacactgctggcc
atgtccagctctccagagagctgtgtagccatgcgccgctcgggctgtctgccactgctg
ctccagatccttcatggcactgaggctgggtctgtggggcgcgcagggatccccggagcg
cctggtgccaaagatgcacgcatgcgcgccaatgcggccctgcacaacatcgttttctcc
cagccggatcagggcctggcacgcaaggagatgcgtgtgctgcatgtgctggagcagatc
cgagcctactgcgagacctgctgggactggcttcaggcgcgggacagcgggacagaaagt
ggtacaggagacactcctgtcccaatcgagccgcagatctgccaggctacctgtgcagtg
atgaagctgtcatttgacgaagaataccgtcgggctatgaatgagctaggggggctgcag
gctgtggcagaactactgcaggtggactatgaaatgcacaagatgacccgggacccactc
aaccttgccctgcgccgctacgctggcatgaccctcaccaacctcacctttggagacgtt
gccaacaaggccacactgtgtgcccgccgaggctgcatggaagccattgtggcccagctt
ggctctgagagcgaggagctgcatcaggttgtttccagtattctgcgtaatctgtcatgg
agggcagacatcaacagcaagaaggtgctgagggaggttggcagcatgaccgccttgatg
gaatgtgtgctgcgggcctccaaggagtcgaccctaaagagtgtgctcagtgctctgtgg
aacctgtcagcacacagcacagagaacaaggcagccatctgccaggtagatggtgcactg
ggtttcctggtgagcaccctcacataccgttgccaagggaactccctggcagtcatcgag
agtggcggtgggatcctgcgcaacgtgtcaagcctcattgccacacgggaggactacagg
caggtgctccgtgaccacaactgcctgcagacactgctgcagcacctcacatcacacagt
ttgaccatcgtgagcaatgcctgtggcaccctctggaacctgtctgcccgcagcccccgc
gatcaggaactgttgtgggacctgggggccgtgggcatgctacgcaacctcgtccactcc
aaacacaagatgatcgccatgggtagtgctgctgctctgcggaacctgctagcccaccga
cccgccaagtatcaggccgcagccatggctgtctccccaggcacctgcgtgcccagtctt
tacgtccgcaagcagagggctctggaagctgagttggacactcggcacctggtgcatgca
ctcggtcacttagagaagcagagtctgcctgaggcagagaccacttcaaagaagcccctg
ccacccctccgccacctggacgggctggtgcaggactatgcctctgattctggctgcttt
gacgatgatgatgcaccatccctggctgctgctgccaccacagctgagcccgccagccca
gcagtgatgtctatgttccttggcggtcccttccttcagggccaggcactggcccgcacc
ccacctgcccgccagggtggcctagaagccgagaaggaggctggtggggaggcagctgtg
gctgccaaggccaaggccaagctggcgttggctgtggctcggatcgacagattggtggag
gacatctctgccctgcacacctcatcagacgacagcttcagtctcagctcgggggaccct
gggcaggaggcgccaagggagggccgtgctcagtcctgctctccatgccggggcactgag
ggtgggaggcgtgaggctggcagccgggcgcaccctcttttgaggctcaaggcagcccac
actagcctctctaatgatagcttgaacagcggtagcaccagcgatggctactgtacccgg
gaacacatgacgccttgcccgctggctgcactggccgagcaccgtgatgaccctgtgcgc
ggacagactcggcccagccgactggacctggaccttcccagccgggctgagcttcctgcc
cgggacacagcagccaccgatgcccgagtgcgcacaatcaagttatccccaacctatcag
catgttccactgctggatggggccgctggggcaggtgttcgacccctggttgggccggga
acctccccgggggctcggaaacaggcatggatacctgcagacagcctgagcaaagtccct
gagaaactggtggcctctccactgcccatagctagcaaggtgctgcagaagctggtcgca
caggatgggccgatgtccctctccaggtgcagctctctgtcctctctatcttccacgggc
catgctgtccccagccaggcagagaaccttgacagcgattcatccctggaggggcttgag
gaggctggtcctggtgaggccgagctgggcagggcgtggcgagcatccgggtccacctct
cttccggtgtccatcccagccccgcagcgggggcgcagtagaggtcttggggtggaggat
gcaacaccatccagctcatctgagaactgcgtccaggagacgcctttggtcctgagccgt
tgtagttccgtgagctccctgggcagcttcgagagccgctccattgccagctccatcccc
agtgacccgtgcagcgggctgggcagtggcacagtgagtcccagcgagctgccagacagc
cccgggcagacgatgccaccgagccgcagcaagacgccaccggcacctcctgggcagcct
gagaccagccagttcagcctgcagtgggaaagctatgtgaagcgcttcctagacatcgca
gactgtcgagaaagatgccagccgccctcggagctggacgcgggcagcgttcgcttcaca
gtggagaagccagatgagaatttctcctgcgcctccagcctcagtgcactggcccttcat
gagctgtatgtccagcaggatgtggagctgcgtctgaggccacctgcctgcccagagcgt
gcggtgggtggtgggggccaccgtcggagggacgaggctgccagccgcctggatggtcca
gcaccagctggttctagggctcggtcagcaactgataaagaactggaggctttgcgtgaa
tgcctgggggcagccatgcccgcccggctccgcaaggtggcctcggccttggtgcctggc
cgccgctcattgccagtccctgtgtacatgttagtgcccgccccggctcggggtgatgac
tcgggcacggactccgcagagggcacacccgttaacttttccagtgcagcctcgctcagt
gacgagaccttacagggaccctccagggacaagccagccgggcctggggacaggcagaaa
cctacaggccgagctgcccctgccaggcagacccgatctcaccggcccaaagcagcaggc
gctggtaagagcacagaacacacccgggggccctgtaggaaccgggcaggattggagcta
ccactcagcaggccccagagtgctcggtccaacagggatagctcatgccagacccggacc
cgcggagatggtgccctgcagtcgctatgcctcacaacacccacagaggaagctgtgtac
tgcttctatgactctgatgaggaaccaccagccactgcaccaccacctcggcgggcatcc
gccatcccacgggctctaaagcgcgagaaaccggcaggcagaaaggagactccatccagg
gcagcccagcctgccacactccctgtgagagcccaacccagactgatcgtggatgagacc
ccgccctgctattccctgacttcctcagctagttccctcagtgagcctgaggcccctgaa
cagccggccaaccatgctcgaggcccggagcagggtagtaaacaggacagctctcctagc
ccaagggcagaagaggaacttctgcagagatgtatcagcttggccatgcccaggcgccgg
acccaggtgcctggctcacggcgtcgcaagcccagagccttgaggtcagacataaggccc
actgagataacccagaaatgccaggaggaggtggctggctccgatccagcctctgaccta
gacagtgtggagtggcaggctatccaagagggcgcaaactccattgtcacatggctgcat
caggcagcggccaaagccagcctggaagcatcttctgagtctgactccctcttgtctttg
gtgtccggggtgtcagcaggctccaccctccagccctccaagctcaggaaagggcgaaag
cctgcagcagaggctggaggtgcctggcgtcctgagaaacggggcacaacttccactaag
atcaatgggagtccccggctacctaacggtcctgagaaggcaaagggtacccagaaaatg
atggcaggggagtcaaccatgctccggggacggacagtgatctactcagccggcccagcc
tcccgcactcagtccaaaggtatttctggaccttgtaccacacctaagaagacagggaca
tctggtaccactcagccagaaactgtcaccaaagcccccagccctgagcaacaacgttca
cggagcctccaccgaccgggcaagatctctgagctggcagctttgcgccacccgcccagg
agtgccactcctccagcccgcctcgccaagaccccgtcctcaagctcttcacagacctct
ccagcatcccagcccctgcctaggcggtcccctctggccactcccacaggaggacctctg
cctggccctggggggtccctggtgcccaagtcaccagcacgggcccttctggctaagcaa
cacaagacccagaagtcacctgtgcggatcccattcatgcaaaggccagccaggcgagtg
ccacctccactggccaggccatccccagaacctggctctaggggccgagctggggctgag
ggtactcctggggcacgtggcagccgcctgggcctggtgcgtatggcttcagctcgctcc
agtggcagcgagtcctcggatcgctcaggcttccgaagacagctgactttcatcaaggaa
tccccaggtctccttcggcgtcgcagatcagagctgtcctctgcggactccacggcctcc
acctcccaggctgcttcgccccgccgtggacggcctgcactccctgctgtctttctctgc
tcctctcgttgcgatgagctgcgggtatccccacggcagcccctggcagcacagaggtcc
ccacaggccaagccaggtctcgccccacgtgcgcccagacgcaccagctctgagagcccc
tcacgcctgcctgtgcgggcgagccctggacggcctgagacagtcaagcggtacgcatcc
ctgccacatattagtgtgtcccgcaggtccgatagcgctgtctctgtgcccaccacccag
gccaatgccactcgccggggaagtgatggcgaggccaggccgctgcccagggtagctcct
ccgggtacgacctggcgtcgaatcaaagatgaagatgtcccccacatcctgcgcagcaca
ctgcctgccactgccctgcctctcagggtctcgtcacccgaagacagccccgctggaact
ccacagcgcaagaccagtgacgcagtggtgcaaacagaggacgtggccacttctaagacc
aactctagcacgtcacctagcctggagagcagggatccgccacaggcccctgccagcggc
cctgtggctccccagggcagcgatgtggatggaccagtactcaccaagcctcctgcctca
gcgcccttcccccatgagggtctgagtgctgtcatagcaggctttcccaccagcaggcat
ggctcccccagcagggctgcacgggttccccccttcaactatgtgcccagccctatggca
gcggccacaatggccagtgactccgcagtggagaaagccccggtctcctctccagccagt
ctcctggagtag

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