KEGG   Mus musculus (house mouse): 23821
Entry
23821             CDS       T01002                                 
Symbol
Bace1, ASP2, Bace
Name
(RefSeq) beta-site APP cleaving enzyme 1
  KO
K04521  beta-site APP-cleaving enzyme 1 (memapsin 2) [EC:3.4.23.46]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu05010  Alzheimer disease
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    23821 (Bace1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:mmu01002]
    23821 (Bace1)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.23  Aspartic endopeptidases
    3.4.23.46  memapsin 2
     23821 (Bace1)
Peptidases and inhibitors [BR:mmu01002]
 Aspartic peptidases
  Family A1: pepsin family
   23821 (Bace1)
SSDB
Motif
Pfam: Asp TAXi_C TAXi_N
Other DBs
NCBI-GeneID: 23821
NCBI-ProteinID: NP_035922
MGI: 1346542
Ensembl: ENSMUSG00000032086
UniProt: P56818 Q8C4F4
Position
9:45749878..45775694
AA seq 501 aa
MAPALHWLLLWVGSGMLPAQGTHLGIRLPLRSGLAGPPLGLRLPRETDEESEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAGFPLNQTEALASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRHQHDDFADDISLLK
NT seq 1506 nt   +upstreamnt  +downstreamnt
atggccccagcgctgcactggctcctgctatgggtgggctcgggaatgctgcctgcccag
ggaacccatctcggcatccggctgccccttcgcagcggcctggcagggccacccctgggc
ctgaggctgccccgggagaccgacgaggaatcggaggagcctggccggagaggcagcttt
gtggagatggtggacaacctgaggggaaagtccggccagggctactatgtggagatgacc
gtaggcagccccccacagacgctcaacatcctggtggacacgggcagtagtaactttgca
gtgggggctgccccacaccctttcctgcatcgctactaccagaggcagctgtccagcaca
tatcgagacctccgaaagggtgtgtatgtgccctacacccagggcaagtgggagggggaa
ctgggcaccgacctggtgagcatccctcatggccccaacgtcactgtgcgtgccaacatt
gctgccatcactgaatcggacaagttcttcatcaatggttccaactgggagggcatccta
gggctggcctatgctgagattgccaggcccgacgactctttggagcccttctttgactcc
ctggtgaagcagacccacattcccaacatcttttccctgcagctctgtggcgctggcttc
cccctcaaccagaccgaggcactggcctcggtgggagggagcatgatcattggtggtatc
gaccactcgctatacacgggcagtctctggtacacacccatccggcgggagtggtattat
gaagtgatcattgtacgtgtggaaatcaatggtcaagatctcaagatggactgcaaggag
tacaactacgacaagagcattgtggacagtgggaccaccaaccttcgcttgcccaagaaa
gtatttgaagctgccgtcaagtccatcaaggcagcctcctcgacggagaagttcccggat
ggcttttggctaggggagcagctggtgtgctggcaagcaggcacgaccccttggaacatt
ttcccagtcatttcactttacctcatgggtgaagtcaccaatcagtccttccgcatcacc
atccttcctcagcaatacctacggccggtggaggacgtggccacgtcccaagacgactgt
tacaagttcgctgtctcacagtcatccacgggcactgttatgggagccgtcatcatggaa
ggtttctatgtcgtcttcgatcgagcccgaaagcgaattggctttgctgtcagcgcttgc
catgtgcacgatgagttcaggacggcggcagtggaaggtccgtttgttacggcagacatg
gaagactgtggctacaacattccccagacagatgagtcaacacttatgaccatagcctat
gtcatggcggccatctgcgccctcttcatgttgccactctgcctcatggtatgtcagtgg
cgctgcctgcgttgcctgcgccaccagcacgatgactttgctgatgacatctccctgctc
aagtaa

  All links  
Gene (14)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (8)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (5)   
DNA sequence (55)   
   RefSeq(nuc) (5)   
   GenBank (25)   
   EMBL (25)   
Protein domain (3)   
   Pfam (3)   
All databases (80)   

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