KEGG   Mus musculus (mouse): 23821
Entry
23821             CDS       T01002                                 

Gene name
Bace1, ASP2, Bace, C76936
Definition
(RefSeq) beta-site APP cleaving enzyme 1
  KO
K04521  beta-site APP-cleaving enzyme 1 (memapsin 2) [EC:3.4.23.46]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu05010  Alzheimer disease
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    23821 (Bace1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:mmu01002]
    23821 (Bace1)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.23  Aspartic endopeptidases
    3.4.23.46  memapsin 2
     23821 (Bace1)
Peptidases and inhibitors [BR:mmu01002]
 Aspartic peptidases
  Family A1: pepsin family
   23821 (Bace1)
SSDB
Motif
Pfam: Asp TAXi_C TAXi_N
Other DBs
NCBI-GeneID: 23821
NCBI-ProteinID: NP_035922
MGI: 1346542
Ensembl: ENSMUSG00000032086
Vega: OTTMUSG00000034962
UniProt: P56818 Q8C4F4
Position
9; 9 A5.2
AA seq 501 aa
MAPALHWLLLWVGSGMLPAQGTHLGIRLPLRSGLAGPPLGLRLPRETDEESEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAGFPLNQTEALASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRHQHDDFADDISLLK
NT seq 1506 nt   +upstreamnt  +downstreamnt
atggccccagcgctgcactggctcctgctatgggtgggctcgggaatgctgcctgcccag
ggaacccatctcggcatccggctgccccttcgcagcggcctggcagggccacccctgggc
ctgaggctgccccgggagaccgacgaggaatcggaggagcctggccggagaggcagcttt
gtggagatggtggacaacctgaggggaaagtccggccagggctactatgtggagatgacc
gtaggcagccccccacagacgctcaacatcctggtggacacgggcagtagtaactttgca
gtgggggctgccccacaccctttcctgcatcgctactaccagaggcagctgtccagcaca
tatcgagacctccgaaagggtgtgtatgtgccctacacccagggcaagtgggagggggaa
ctgggcaccgacctggtgagcatccctcatggccccaacgtcactgtgcgtgccaacatt
gctgccatcactgaatcggacaagttcttcatcaatggttccaactgggagggcatccta
gggctggcctatgctgagattgccaggcccgacgactctttggagcccttctttgactcc
ctggtgaagcagacccacattcccaacatcttttccctgcagctctgtggcgctggcttc
cccctcaaccagaccgaggcactggcctcggtgggagggagcatgatcattggtggtatc
gaccactcgctatacacgggcagtctctggtacacacccatccggcgggagtggtattat
gaagtgatcattgtacgtgtggaaatcaatggtcaagatctcaagatggactgcaaggag
tacaactacgacaagagcattgtggacagtgggaccaccaaccttcgcttgcccaagaaa
gtatttgaagctgccgtcaagtccatcaaggcagcctcctcgacggagaagttcccggat
ggcttttggctaggggagcagctggtgtgctggcaagcaggcacgaccccttggaacatt
ttcccagtcatttcactttacctcatgggtgaagtcaccaatcagtccttccgcatcacc
atccttcctcagcaatacctacggccggtggaggacgtggccacgtcccaagacgactgt
tacaagttcgctgtctcacagtcatccacgggcactgttatgggagccgtcatcatggaa
ggtttctatgtcgtcttcgatcgagcccgaaagcgaattggctttgctgtcagcgcttgc
catgtgcacgatgagttcaggacggcggcagtggaaggtccgtttgttacggcagacatg
gaagactgtggctacaacattccccagacagatgagtcaacacttatgaccatagcctat
gtcatggcggccatctgcgccctcttcatgttgccactctgcctcatggtatgtcagtgg
cgctgcctgcgttgcctgcgccaccagcacgatgactttgctgatgacatctccctgctc
aagtaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (8)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
   VEGA (1)   
Protein sequence (7)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (4)   
DNA sequence (54)   
   RefSeq(nuc) (4)   
   GenBank (25)   
   EMBL (25)   
Protein domain (3)   
   Pfam (3)   
All databases (87)   

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KEGG   Mus musculus (mouse): 56175
Entry
56175             CDS       T01002                                 

Gene name
Bace2, 1110059C24Rik, A, AEPLC, AI850424, AL, ALP56, ARP1, AS, ASP1, ASP21, BAE, BAE2, CDA1, CDA13, CEA, CEAP1, DRAP
Definition
(RefSeq) beta-site APP-cleaving enzyme 2
  KO
K07747  beta-site APP-cleaving enzyme 2 (memapsin 1) [EC:3.4.23.45]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu05010  Alzheimer disease
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    56175 (Bace2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors [BR:mmu01002]
    56175 (Bace2)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.23  Aspartic endopeptidases
    3.4.23.45  memapsin 1
     56175 (Bace2)
Peptidases and inhibitors [BR:mmu01002]
 Aspartic peptidases
  Family A1: pepsin family
   56175 (Bace2)
SSDB
Motif
Pfam: Asp TAXi_C TAXi_N
Other DBs
NCBI-GeneID: 56175
NCBI-ProteinID: NP_062390
MGI: 1860440
Ensembl: ENSMUSG00000040605
UniProt: Q9JL18 A0A0R4J0I8
Position
16; 16 C4
AA seq 514 aa
MGALLRALLLPVLAQWLLSAVPALAPAPFTLPLQVARATNHRASAVPGLGTPELPRADGL
ALALEPVRATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVQILVDTGSSNFAVAGAPHS
YIDTYFDSESSSTYHSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESE
NFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGT
NGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQNLNLDCREYNADKAIVDS
GTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRD
ENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQR
RVGFAVSPCAEIEGTTVSEISGPFSTEDIASNCVPAQALNEPILWIVSYALMSVCGAILL
VLILLLLLPLHCRHAPRDPEVVNDESSLVRHRWK
NT seq 1545 nt   +upstreamnt  +downstreamnt
atgggcgcgctgcttcgagcactcttgctcccggtgctggcgcagtggctcttgagtgcg
gtccccgcgctggcccccgcgcccttcacgctgcccctccaagtggcccgggccacgaac
cacagagcctcggctgttcccggactcgggacccccgagttgccccgggccgatggtctg
gccctcgcactggagcctgtcagggctactgccaacttcttggctatggtggacaacctt
cagggggactctggccgcggctactacctagagatgctgatcgggacccctccgcagaag
gtacagattcttgtggacactggaagcagtaacttcgctgtggcaggtgccccacactcc
tacatagacacctactttgactcagagagctccagcacataccactccaagggctttgat
gtcactgtgaagtacacacagggaagctggactggctttgttggtgaggaccttgtcacc
atcccaaaaggcttcaacagctctttcttggtcaatattgccactattttcgagtctgag
aatttctttttgcctggtattaaatggaatggaatccttggacttgcttatgctgctttg
gccaagccatcaagctctctggagacattttttgattccctggtggcccaagcaaagatt
ccagacattttctccatgcagatgtgcggggctggattgccagtagctggttctggtacc
aacggaggtagtcttgtcctgggtgggattgaaccaagtttgtataaaggagatatctgg
tataccccaattaaagaggaatggtactatcaaatagaaatcctgaagttggaaattgga
ggccagaacctcaacctggactgcagagagtataacgcagacaaggccattgtggacagt
ggcaccacgctcctgcgcctgccccagaaggtgtttgatgcagtggtggaagctgtggca
cgaacatctctgattccagagttttctgatggcttctggacaggggcccagctggcatgc
tggacaaattctgaaacgccatgggcatatttccctaagatttctatctacctgagagat
gagaatgccagtcgctccttccggatcaccattctcccacagctctacattcagcccatg
atgggagctggtttcaattatgaatgctaccgttttggtatctcctcttccacaaatgcg
ctggtgattggtgcgaccgtgatggaaggcttctacgtggtctttgacagagctcagagg
agggtgggctttgcagtgagtccctgtgcagagattgaaggtaccacagtgtctgaaatt
tctgggcccttttccacggaagacatagccagcaactgtgttccagcacaggctctgaat
gagcccatcttgtggattgtgtcctatgccctgatgagtgtgtgtggagccattctcctg
gttctgatcctcctcctgctgctcccgctgcactgccgtcatgccccccgagaccctgag
gtagttaacgatgagtcctcactagtcagacatcgctggaaatga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (16)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (9)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (5)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (2)   
DNA sequence (46)   
   RefSeq(nuc) (2)   
   GenBank (22)   
   EMBL (22)   
Protein domain (3)   
   Pfam (3)   
All databases (76)   

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