KEGG   Mus musculus (house mouse): 269881
Entry
269881            CDS       T01002                                 
Symbol
Map3k10, MST, Mlk2
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 10
  KO
K04418  mitogen-activated protein kinase kinase kinase 10 [EC:2.7.11.25]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04010  MAPK signaling pathway
mmu05016  Huntington disease
mmu05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    269881 (Map3k10)
   05022 Pathways of neurodegeneration - multiple diseases
    269881 (Map3k10)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    269881 (Map3k10)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     269881 (Map3k10)
Protein kinases [BR:mmu01001]
 Serine/threonine kinases: TKL group
  MLK family
   269881 (Map3k10)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH3_9 SH3_1 SH3_2 Pkinase_fungal OmpH RNase_Y_N
Other DBs
NCBI-GeneID: 269881
NCBI-ProteinID: NP_001277457
MGI: 1346879
Ensembl: ENSMUSG00000040390
UniProt: Q66L42
Position
7:complement(27355800..27374059)
AA seq 940 aa
MEEEEGAAAREWGATPAGPVWTAVFDYEAVGDEELTLRRGDRVQVLSQDCAVSGDEGWWT
GQLPSGRVGVFPSNYVAPAAPAAPSDLQLPQEIPFHELQLEEIIGVGGFGKVYRAVWRGE
EVAVKAARLDPERDPAVTAEQVRQEARLFGALQHPNIIALRGACLSPPNLCLVMEYARGG
ALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLA
DTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGE
VPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQLEVI
EQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLR
RREQELAEREMDIVERELHLLMSQLSQEKPRVRKRKGNFKRSRLLKLREGSSHISLPSGF
EHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPMDCGGSSGSGTWSRSGPPKK
EELVGGKKKGRTWGPSSTLQKERAGGEERLKALGEGSKQWSSSAPNLGKSPKHTPMAPGF
ASLNEMEEFAEADEGNNVPPSPYSTPSYLKVPLPAEPSPCVQAPWEPPAVTPSRPGHGAR
RRCDLALLSCATLLSAVGLGADVAEARAGDGEEQRRWLDSLFFPRPGRFPRGLSPTGRPG
GRREDTAPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPLAPSPSTN
PLVDVELESFKKDPRQSLTPTHVTAAHAVSRGHRRTPSDGALRQREPLELTNHGPRDPLD
FPRLPDPQALFPTRRRPLEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLSISPPS
RPDTPESPGPPSVQPTLLDMDMEGQSQDNTVPLCGVYGSH
NT seq 2823 nt   +upstreamnt  +downstreamnt
atggaggaggaggagggggcggcggccagagagtggggcgcgacccccgcggggccagtg
tggaccgccgtgttcgactacgaggcggtgggcgacgaggagctgaccctgcggagaggc
gaccgcgtccaggtgctttcccaggactgtgcggtgtctggagatgagggctggtggaca
gggcagctgcccagcggccgtgtgggcgtcttccccagcaactacgtggcccccgctgca
cccgccgcaccctcagacctccagctgccacaggagatccccttccacgagctgcagctg
gaggagatcatcggtgtcgggggctttggcaaagtctatcgcgccgtatggcgtggagag
gaagtagcggtcaaggccgctcggctggaccctgaacgggacccggcagtgacagcggag
caggtccgccaggaggcccggctctttggagccctgcagcaccccaacatcattgccctg
aggggcgcctgcctcagccccccaaacctctgcctggtgatggaatatgctcggggaggt
gcattgagcagggtactggcaggtcgccgggtcccccctcatgtgctggtcaactgggct
gtgcaggtggctcggggcatgaactatctacacaatgatgcccctgtgcccatcattcac
cgggacctcaagtccatcaacatcctaatcctggaggccattgagaaccacaacctcgct
gacacggtgctcaagatcacagacttcggccttgcccgagagtggcacaagacgaccaaa
atgagtgcagcggggacctacgcctggatggctcctgaggttatccgcctgtccctcttc
tccaaaagcagcgacgtctggagcttcggggttcttctttgggagctgctgaccggggag
gtcccctaccgagaaatcgacgccttggccgtggcttacggtgtggctatgaacaagctg
acgctacccatcccctccacgtgccccgagccctttgcccgcctactggaggaatgctgg
gacccagaccctcacgggcgaccagattttggcagcatcctgaagcagctggaggtcatc
gagcagtcagccctgttccagatgccactggagtccttccactccctgcaggaagactgg
aagctggagattcagcatatgtttgatgaccttcggaccaaggagaaggagttgcgcagc
cgggaagaggagctattgcgggctgcacaggagcagcgttttcaggaagagcagctacgg
cgtcgggagcaggagctggcagagcgagagatggacatcgtagaacgtgagctgcacctg
ctcatgagccagctgagccaggagaagcccagggtccgaaaacgcaagggcaacttcaag
cgcagccgcttgctcaagctacgggaaggaagcagccacatcagcctgccctctggattt
gaacataagatcaccgtccaggcctccccaaccctggacaagaggaaaggatccgatggg
gccagccctcctgccagccccagcatcattccccggttgagggccattcgattgactccc
atggactgtggtggcagcagtggtagtggaacatggagccgcagtgggccaccaaagaag
gaagaactggttgggggcaagaagaaaggcaggacatggggccccagttccactttgcag
aaggagcgagctggaggagaggagaggctcaaggccctgggggaaggaagcaagcagtgg
tcctcgagcgcccccaacctgggcaaatcccctaagcacacccccatggccccaggcttc
gccagcctcaacgagatggaagaatttgcggaggcagatgaaggcaacaacgtgccccct
tctccctactccaccccgtcctacctcaaggtgcctctgcccgccgagccttctccttgt
gttcaggcgccttgggagccgccggctgtcaccccttcccggccaggacacggagctcgt
aggcgctgcgacctggcgctgctaagctgtgccacgctgctgagtgcggtgggcctgggc
gccgacgtggccgaggcacgggccggggacggtgaggagcagcggcgctggctggacagt
ctcttcttcccgcgccccggccgcttccctcgcggtctcagcccaaccgggcgccccgga
ggtcgccgcgaagacacagccccaggcttgggtctggcaccctcggccaccctggtgtca
ttatcctctgtatcggattgtaactctacgcgctcattgctgcgctctgacagtgacgag
gctgcccctgccgccccctccccgccgccttctccgctcgcgccctcacccagcaccaat
cctctcgtggacgtggagttggagagcttcaagaaggacccccggcagtcacttacgccc
acccacgtcactgccgcccacgctgtgagccgtggacacaggcggacgccatcagatggg
gctttgagacaacgggagcctctggagctcaccaaccacggtcctcgagaccccctggac
ttccctcgactgcccgacccccaggccctgttccctacccgacgccggcccctggagttc
cctggccgccccaccaccctcacttttgccccaagaccccggcctgctgccagccgcccc
cgtctggatccctggaaactggtctcctttggccggacactcagcatctcgcctccaagc
aggccagacactccagagagccctgggccccccagcgtgcaacccacgttgctggacatg
gacatggagggccagagccaggacaatacagtgcccctatgtggggtctatggctctcac
tga

  All links  
Gene (21)   
   RefGene (16)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (9)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (7)   
DNA sequence (21)   
   RefSeq(nuc) (13)   
   GenBank (4)   
   EMBL (4)   
Protein domain (8)   
   Pfam (8)   
All databases (59)   

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