KEGG   Mus musculus (house mouse): 384783
Entry
384783            CDS       T01002                                 
Symbol
Irs2, Irs-2
Name
(RefSeq) insulin receptor substrate 2
  KO
K07187  insulin receptor substrate 2
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04022  cGMP-PKG signaling pathway
mmu04068  FoxO signaling pathway
mmu04140  Autophagy - animal
mmu04152  AMPK signaling pathway
mmu04211  Longevity regulating pathway
mmu04213  Longevity regulating pathway - multiple species
mmu04910  Insulin signaling pathway
mmu04920  Adipocytokine signaling pathway
mmu04923  Regulation of lipolysis in adipocytes
mmu04930  Type II diabetes mellitus
mmu04931  Insulin resistance
mmu04932  Non-alcoholic fatty liver disease
mmu04935  Growth hormone synthesis, secretion and action
mmu05010  Alzheimer disease
mmu05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    384783 (Irs2)
   04022 cGMP-PKG signaling pathway
    384783 (Irs2)
   04152 AMPK signaling pathway
    384783 (Irs2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    384783 (Irs2)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    384783 (Irs2)
   04923 Regulation of lipolysis in adipocytes
    384783 (Irs2)
   04920 Adipocytokine signaling pathway
    384783 (Irs2)
   04935 Growth hormone synthesis, secretion and action
    384783 (Irs2)
  09149 Aging
   04211 Longevity regulating pathway
    384783 (Irs2)
   04213 Longevity regulating pathway - multiple species
    384783 (Irs2)
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    384783 (Irs2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    384783 (Irs2)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    384783 (Irs2)
   04932 Non-alcoholic fatty liver disease
    384783 (Irs2)
   04931 Insulin resistance
    384783 (Irs2)
SSDB
Motif
Pfam: IRS PH PH_11 MEKK4_N
Other DBs
NCBI-GeneID: 384783
NCBI-ProteinID: NP_001074681
MGI: 109334
Ensembl: ENSMUSG00000038894
UniProt: P81122
Structure
Position
8:complement(11034681..11058929)
AA seq 1321 aa
MASAPLPGPPASAGGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGTGGDEA
SAAGGSPPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDE
YFAVAAENEQEQEGWYRALTDLVSEGRSGEGGSGTTGGSCSASLPGVLGGSAGAAGCDDN
YGLVTPATAVYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTLQLM
NIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEFRPR
SKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCTSCRVRT
ASEGDGGAAGGAGTAGGRPMSVAGSPLSPGPVRAPLSRSHTLSAGCGGRPSKVTLAPAGG
ALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPLPPGSHPHLPHPLHHPQGQRPSS
GSASASGSPSDPGFMSLDEYGSSPGDLRAFSSHRSNTPESIAETPPARDGSGGELYGYMS
MDRPLSHCGRPYRRVSGDGAQDLDRGLRKRTYSLTTPARQRQVPQPSSASLDEYTLMRAT
FSGSSGRLCPSFPASSPKVAYNPYPEDYGDIEIGSHKSSSSNLGADDGYMPMTPGAALRS
GGPNSCKSDDYMPMSPTSVSAPKQILQPRLAAALPPSGAAVPAPPSGVGRTFPVNGGGYK
ASSPAESSPEDSGYMRMWCGSKLSMENPDPKLLPNGDYLNMSPSEAGTAGTPPDFSAALR
GGSEGLKGIPGHCYSSLPRSYKAPCSCSGDNDQYVLMSSPVGRILEEERLEPQATPGAGT
FGAAGGSHTQPHHSAVPSSMRPSAIGGRPEGFLGQRCRAVRPTRLSLEGLQTLPSMQEYP
LPTEPKSPGEYINIDFGEAGTRLSPPAPPLLASAASSSSLLSASSPASSLGSGTPGTSSD
SRQRSPLSDYMNLDFSSPKSPKPSTRSGDTVGSMDGLLSPEASSPYPPLPPRPSTSPSSL
QQPLPPAPGDLYRLPPASAATSQGPTAGSSMSSEPGDNGDYTEMAFGVAATPPQPIVAPP
KPEGARVASPTSGLKRLSLMDQVSGVEAFLQVSQPPDPHRGAKVIRADPQGGRRRHSSET
FSSTTTVTPVSPSFAHNSKRHNSASVENVSLRKSSEGSSTLGGGDEPPTSPGQAQPLVAV
PPVPQARPWNPGQPGALIGCPGGSSSPMRRETSVGFQNGLNYIAIDVRGEQGSLAQSQPQ
PGDKNSWSRTRSLGGLLGTVGGSGASGVCGGPGTGALPSASTYASIDFLSHHLKEATVVK
E
NT seq 3966 nt   +upstreamnt  +downstreamnt
atggctagcgcgcccctgcctgggccccccgcgtcggcgggcggggacggcccgaacctc
aataacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcag
aagcacggccacaagcgctttttcgtgttgcgcggccccggcacgggcggcgacgaggca
tccgcggctggggggtcgccgccgcagcctccgcggctggagtactacgagagcgagaag
aagtggaggagcaaggcgggcgcgccgaagcgagtgatcgcgctcgactgctgtctgaac
atcaacaagcgcgcggacgccaagcacaagtacctgatcgccctctacaccaaggacgag
tacttcgctgtagcggcggagaacgagcaggagcaggagggctggtaccgcgcactcacc
gacttggtcagcgaaggccgctctggcgaggggggctcgggcaccaccggaggctcttgc
agcgcctctctcccgggcgtcctgggcggctcagcgggcgccgctggctgcgatgacaac
tacgggctcgtgacacccgccacggccgtctaccgcgaggtgtggcaggtgaacctgaaa
cctaagggactgggccagagcaagaacctgactggtgtataccgcctatgcctgtctgcg
cgcaccatcggcttcgtgaagctcaattgcgaacagccgtcggtgacgctgcagcttatg
aacattcgccgctgcggccactcggacagcttcttcttcatcgaggtgggccgttcggcc
gtcaccggtcccggggagctgtggatgcaagccgacgactcggtggtggcgcagaacatc
catgagaccatcctagaagctatgaaggcactcaaagagctcttcgagttccggcctcgc
agcaagagtcagtcgtccgggtcgtcagccacgcatcccatcagcgtgccgggcgcgcgc
cgccaccaccacctagtcaacctaccccctagccagaccggcctggtgcgccgctcgcgc
actgacagcctggcggccacccccccagcagccaagtgcacttcgtgccgggttcgtacg
gccagcgagggcgacggcggcgcggcaggcggggccgggacggcaggaggcaggccgatg
tcggtggcagggagccccctgagtcccgggccggtgcgcgcgccccttagccgctcgcac
accctgagcgccggctgcggaggccgcccgagcaaagtgactctggcgccggcaggggga
gccctgcaacacagccgctccatgtccatgcccgtggcgcactcacctcctgcagccacc
agcccaggcagcctgtcctccagcagtgggcacggctcgggctcctacccgctgccacct
ggctcccacccgcacctgcctcatccactgcatcacccccaaggccagcgtccgtccagc
ggtagtgcctccgcctcgggctcccccagcgacccgggtttcatgtcccttgacgagtat
ggctccagccctggcgacctgagagccttcagtagccacaggagcaacacacccgagtca
atagcggagaccccgccagccagagatggcagtgggggcgaactctatgggtacatgagc
atggatagacccctgagccactgtggccgcccttaccgtagggtctcaggggatggggcc
caggacctggatagaggactgaggaagaggacttattccctaaccacgcctgccaggcag
cggcaggtacctcagccttcctctgcctctctagatgaatacactctcatgagggccacc
ttctctggtagttcaggtcgcctctgcccatccttccctgcgtcctctcccaaagtggcc
tacaacccttacccagaggactatggagacattgagattggttctcacaagagttccagc
agtaacctgggggcagatgatggctacatgcccatgacccctggggcagcccttaggagt
ggtggtcccaatagctgcaagagcgatgactacatgcccatgagccccacaagcgtgtct
gctcccaagcagatcctgcagccacgcttggcagcggccttgcccccttccggagcagcc
gtgccagcacccccttcaggggtgggcaggaccttcccagtaaacggaggtggctacaaa
gccagctccccagcggagagctccccagaagacagtgggtacatgcgaatgtggtgtggc
tccaagctgtctatggagaacccagaccctaagctactccccaacggggactacctcaac
atgtcccccagcgaggcaggcactgcagggaccccacctgacttctcagcagctttgcgt
ggaggcagtgaaggcctcaaaggcatcccgggccactgctacagctctttgccccgctct
tataaggctccctgttcctgcagcggagacaatgaccagtatgtgctcatgagctcccct
gtgggccggatcttggaagaggagagactggagccccaggccaccccaggggctggcacc
tttggggcagctggtggtagtcatacccagcctcatcactcagcagtgccttcctccatg
aggccgagtgccatcggtggccgccctgagggcttcctgggccagcgatgtcgggcagtg
cggcctacacgcctatcgctagagggactgcagacccttcccagcatgcaagagtaccct
ctacccacagagcccaagagccctggcgagtacatcaacattgactttggtgaggcaggt
acccgtctgtctccgcctgcccccccactactggcatccgcggcctcatcttcttcactg
ctctcagctagtagtcctgcttcatccctgggttcaggaaccccaggcaccagcagcgac
agccggcagcgctctccactctctgactatatgaacctggacttcagttctcccaagtcc
cccaagcctagcacccgcagtggggacacagtaggctccatggatggccttctctctcca
gaggcttcatccccatacccaccactgcccccacgtccttccacttccccttcctcctta
cagcagcctctgccacctgccccgggagacctataccgcctgcctccagcatcagctgcc
acttcccagggtcccactgctggctcctcaatgtcctccgagcctggggataatggtgac
tataccgagatggcctttggtgtggctgcaaccccgccacaacctatcgtggcacctcca
aagccagaaggtgcccgagtggccagtcccacatcgggcttgaagcggctaagtctcatg
gatcaggtatctggggtggaggctttccttcaagtcagccagccccctgacccccaccgg
ggtgctaaggtcatccgtgcagacccacaggggggacgtcgtcgccacagttcagagacc
ttttcctctaccaccaccgtcaccccagtgtccccatcctttgcccacaattccaagcgc
cacaattcggcctctgtggaaaatgtctcactcaggaaaagcagtgaaggcagcagtacc
ctgggaggaggtgatgagccgcccacatccccaggacaggcacagcccttggtggctgtg
cccccagtgccacaggctaggccgtggaaccccggtcagcccggagctttgattggctgt
cctggaggcagcagttctcccatgcgcagagagacctccgtgggtttccagaacggcctc
aactatatcgccatcgatgtgagaggcgagcaggggtccttggcgcagtctcagccgcag
ccaggagacaagaactcctggagccggacccgtagccttggggggctcctcggcaccgtc
ggaggctctggcgccagcggagtgtgtgggggtccaggcactggagctttgccctctgcc
agcacctatgcaagcatcgacttcctgtcccatcacttgaaggaagccacagtcgtgaaa
gagtga

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