KEGG   Mus musculus (mouse): 56480
Entry
56480             CDS       T01002                                 

Gene name
Tbk1, 1200008B05Rik, AI462036, AW048562
Definition
(RefSeq) TANK-binding kinase 1
  KO
K05410  TANK-binding kinase 1 [EC:2.7.11.10]
Organism
mmu  Mus musculus (mouse)
Pathway
mmu04014  Ras signaling pathway
mmu04137  Mitophagy - animal
mmu04140  Autophagy - animal
mmu04620  Toll-like receptor signaling pathway
mmu04621  NOD-like receptor signaling pathway
mmu04622  RIG-I-like receptor signaling pathway
mmu04623  Cytosolic DNA-sensing pathway
mmu04657  IL-17 signaling pathway
mmu05014  Amyotrophic lateral sclerosis
mmu05022  Pathways of neurodegeneration - multiple diseases
mmu05135  Yersinia infection
mmu05160  Hepatitis C
mmu05161  Hepatitis B
mmu05162  Measles
mmu05163  Human cytomegalovirus infection
mmu05164  Influenza A
mmu05165  Human papillomavirus infection
mmu05167  Kaposi sarcoma-associated herpesvirus infection
mmu05168  Herpes simplex virus 1 infection
mmu05169  Epstein-Barr virus infection
mmu05170  Human immunodeficiency virus 1 infection
mmu05171  Coronavirus disease - COVID-19
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    56480 (Tbk1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    56480 (Tbk1)
   04137 Mitophagy - animal
    56480 (Tbk1)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    56480 (Tbk1)
   04621 NOD-like receptor signaling pathway
    56480 (Tbk1)
   04622 RIG-I-like receptor signaling pathway
    56480 (Tbk1)
   04623 Cytosolic DNA-sensing pathway
    56480 (Tbk1)
   04657 IL-17 signaling pathway
    56480 (Tbk1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    56480 (Tbk1)
   05161 Hepatitis B
    56480 (Tbk1)
   05160 Hepatitis C
    56480 (Tbk1)
   05171 Coronavirus disease - COVID-19
    56480 (Tbk1)
   05164 Influenza A
    56480 (Tbk1)
   05162 Measles
    56480 (Tbk1)
   05168 Herpes simplex virus 1 infection
    56480 (Tbk1)
   05163 Human cytomegalovirus infection
    56480 (Tbk1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    56480 (Tbk1)
   05169 Epstein-Barr virus infection
    56480 (Tbk1)
   05165 Human papillomavirus infection
    56480 (Tbk1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    56480 (Tbk1)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    56480 (Tbk1)
   05022 Pathways of neurodegeneration - multiple diseases
    56480 (Tbk1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    56480 (Tbk1)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmu04131]
    56480 (Tbk1)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     56480 (Tbk1)
Protein kinases [BR:mmu01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   56480 (Tbk1)
Membrane trafficking [BR:mmu04131]
 Autophagy
  Xenophagy
   Other xenophagy associated proteins
    56480 (Tbk1)
SSDB
Motif
Pfam: TBK1_CCD1 Pkinase TBK1_ULD PK_Tyr_Ser-Thr Pkinase_fungal CEP63 DUF713 Kinase-like ubiquitin
Other DBs
NCBI-GeneID: 56480
NCBI-ProteinID: NP_062760
MGI: 1929658
Ensembl: ENSMUSG00000020115
UniProt: Q9WUN2 A1L361
Structure
PDB: 
4JLC 4JL9 6O8C

Position
10; 10 D2
AA seq 729 aa
MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLK
KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
HPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
KPSGAISGVQKAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFDQFFA
ETSDVLHRMVIHVFSLQHMTAHKIYIHSYNTAAVFHELVYKQTKIVSSNQELIYEGRRLV
LELGRLAQHFPKTTEENPIFVTSREQLNTVGLRYEKISLPKIHPRYDLDGDASMAKAVTG
VVCYACRTASTLLLYQELMRKGVRWLVELVKDDYNETVHKKTEVVITLDFCIRNIEKTVK
VYEKLMKVNLEAAELGEISDIHTKLLRLSSSQGTIESSLQDISSRLSPGGLLADTWAHQE
GTHPRDRNVEKLQVLLNCITEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMSH
FSEECVRKYEAFKDKSEEWMRKMLHLRKQLLSLTNQCFDIEEEVSKYQDYTNELQETLPQ
KMLAASGGVKHAMAPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD
GGLRNVDCL
NT seq 2190 nt   +upstreamnt  +downstreamnt
atgcagagcacctccaaccatctgtggctcctgtctgatatcctaggccagggggccact
gcaaatgtcttccgaggaaggcataagaaaactggtgatctctatgctgtcaaagtattt
aataacataagcttccttcgcccagtggatgttcaaatgagagaatttgaagtgttaaaa
aaactcaatcacaaaaacattgtcaagttatttgctattgaagaggagacaacaacaaga
cataaagtgcttattatggagttttgtccctgtgggagtttatacactgttctagaggag
ccgtccaatgcgtatggacttccagaatcagaatttctcattgtcttacgagatgtggtg
ggcgggatgaatcatctccgagagaacggcatagtgcaccgagatatcaagccaggcaac
atcatgcgcgtcataggggaggacggccagtctgtgtacaaactcacggatttcggcgcc
gctcgagagctggaggacgatgagcagtttgtgtctctgtacggcacagaagagtacctg
catccggacatgtatgaaagggcagtgctaagaaaggaccatcagaagaagtacggggct
accgttgatctgtggagtgttggagtgacattctaccatgcagccacggggtcgctgccg
tttagacccttcgaggggcctcggaggaacaaagaagtaatgtataaaataatcactggg
aagccgtctggtgcaatatctggagtacagaaagcagaaaacggaccaattgactggagt
ggagacatgcctctctcctgtagtctttctcagggtcttcaggcactgcttaccccagtt
cttgcaaacatacttgaagctgatcaggagaagtgctggggttttgaccagttctttgca
gagaccagtgatgtgcttcaccgaatggtgatccatgtcttctcgctacaacacatgacg
gcgcataagatttacattcacagctataacactgctgctgtgttccatgaactggtctat
aaacaaaccaagattgtttcctcaaatcaagaacttatctacgaaggacgacgcttagtc
ctagaactcggacgactagcccagcattttcctaaaaccacagaggaaaatcctatcttt
gtcacgagccgggaacaactcaataccgtaggactgagatatgaaaaaatttccctccct
aaaatacatccacgctatgatctggatggggacgccagcatggccaaggcagtgacgggg
gttgtgtgctacgcctgcagaactgccagtaccctgctgctctatcaagaattaatgcga
aagggggtacggtggctggttgaactggttaaggatgattacaacgagaccgtccacaag
aagacggaggtagtgatcacactggatttctgcatcaggaacattgagaagactgtgaaa
gtgtatgagaagttgatgaaggtcaacctggaagccgcagagctgggtgagatttcagac
atacacaccaagctgctgagactttccagttctcagggaacaatagaaagcagtcttcag
gacatcagcagcaggctgtctccagggggcttgctggccgacacctgggcacatcaagaa
ggcacgcatccaagagacaggaatgtagaaaaactgcaggtcctgttgaactgcatcaca
gagatttactatcagttcaaaaaagacaaagcagaacgcagactagcttataatgaagaa
cagatccacaaatttgataagcaaaaattgtattaccatgccacaaaagcaatgagccac
ttctcagaagaatgtgttagaaagtatgaagcgtttaaagataagtcggaagagtggatg
agaaagatgcttcatcttaggaagcagctgttatcgctaactaatcagtgtttcgatatc
gaagaggaagtgtccaagtatcaagactatactaacgagttacaagaaactctgcctcag
aaaatgctcgcagcctccggcggcgtcaagcacgccatggccccgatctaccccagctct
aacaccttagtggagatgactcttggtatgaagaagttaaaggaggagatggaaggcgtg
gttaaggagctggccgagaacaatcatattttagaaaggtttgggtctttaacaatggat
ggtggccttcgcaatgtggactgtctttag

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (22)   
   KEGG PATHWAY (22)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (21)   
   RefSeq(nuc) (1)   
   GenBank (10)   
   EMBL (10)   
Protein domain (9)   
   Pfam (9)   
All databases (72)   

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