KEGG   Mus musculus (house mouse): 56480
Entry
56480             CDS       T01002                                 
Symbol
Tbk1, 1200008B05Rik
Name
(RefSeq) TANK-binding kinase 1
  KO
K05410  TANK-binding kinase 1 [EC:2.7.11.10]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04014  Ras signaling pathway
mmu04137  Mitophagy - animal
mmu04140  Autophagy - animal
mmu04620  Toll-like receptor signaling pathway
mmu04621  NOD-like receptor signaling pathway
mmu04622  RIG-I-like receptor signaling pathway
mmu04623  Cytosolic DNA-sensing pathway
mmu04657  IL-17 signaling pathway
mmu04936  Alcoholic liver disease
mmu05014  Amyotrophic lateral sclerosis
mmu05022  Pathways of neurodegeneration - multiple diseases
mmu05135  Yersinia infection
mmu05160  Hepatitis C
mmu05161  Hepatitis B
mmu05162  Measles
mmu05163  Human cytomegalovirus infection
mmu05164  Influenza A
mmu05165  Human papillomavirus infection
mmu05167  Kaposi sarcoma-associated herpesvirus infection
mmu05168  Herpes simplex virus 1 infection
mmu05169  Epstein-Barr virus infection
mmu05170  Human immunodeficiency virus 1 infection
mmu05171  Coronavirus disease - COVID-19
mmu05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    56480 (Tbk1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    56480 (Tbk1)
   04137 Mitophagy - animal
    56480 (Tbk1)
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    56480 (Tbk1)
   04621 NOD-like receptor signaling pathway
    56480 (Tbk1)
   04622 RIG-I-like receptor signaling pathway
    56480 (Tbk1)
   04623 Cytosolic DNA-sensing pathway
    56480 (Tbk1)
   04657 IL-17 signaling pathway
    56480 (Tbk1)
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    56480 (Tbk1)
   05161 Hepatitis B
    56480 (Tbk1)
   05160 Hepatitis C
    56480 (Tbk1)
   05171 Coronavirus disease - COVID-19
    56480 (Tbk1)
   05164 Influenza A
    56480 (Tbk1)
   05162 Measles
    56480 (Tbk1)
   05168 Herpes simplex virus 1 infection
    56480 (Tbk1)
   05163 Human cytomegalovirus infection
    56480 (Tbk1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    56480 (Tbk1)
   05169 Epstein-Barr virus infection
    56480 (Tbk1)
   05165 Human papillomavirus infection
    56480 (Tbk1)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    56480 (Tbk1)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    56480 (Tbk1)
   05022 Pathways of neurodegeneration - multiple diseases
    56480 (Tbk1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    56480 (Tbk1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    56480 (Tbk1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    56480 (Tbk1)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmu04131]
    56480 (Tbk1)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     56480 (Tbk1)
Protein kinases [BR:mmu01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   56480 (Tbk1)
Membrane trafficking [BR:mmu04131]
 Autophagy
  Xenophagy
   Other xenophagy associated proteins
    56480 (Tbk1)
SSDB
Motif
Pfam: TBK1_CCD1 Pkinase TBK1_ULD PK_Tyr_Ser-Thr Pkinase_fungal ABC1 DUF713 CEP63 Kinase-like ubiquitin
Other DBs
NCBI-GeneID: 56480
NCBI-ProteinID: NP_062760
MGI: 1929658
Ensembl: ENSMUSG00000020115
UniProt: Q9WUN2 A1L361
Structure
Position
10:complement(121382360..121422699)
AA seq 729 aa
MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNISFLRPVDVQMREFEVLK
KLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLRDVV
GGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYL
HPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITG
KPSGAISGVQKAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQEKCWGFDQFFA
ETSDVLHRMVIHVFSLQHMTAHKIYIHSYNTAAVFHELVYKQTKIVSSNQELIYEGRRLV
LELGRLAQHFPKTTEENPIFVTSREQLNTVGLRYEKISLPKIHPRYDLDGDASMAKAVTG
VVCYACRTASTLLLYQELMRKGVRWLVELVKDDYNETVHKKTEVVITLDFCIRNIEKTVK
VYEKLMKVNLEAAELGEISDIHTKLLRLSSSQGTIESSLQDISSRLSPGGLLADTWAHQE
GTHPRDRNVEKLQVLLNCITEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMSH
FSEECVRKYEAFKDKSEEWMRKMLHLRKQLLSLTNQCFDIEEEVSKYQDYTNELQETLPQ
KMLAASGGVKHAMAPIYPSSNTLVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMD
GGLRNVDCL
NT seq 2190 nt   +upstreamnt  +downstreamnt
atgcagagcacctccaaccatctgtggctcctgtctgatatcctaggccagggggccact
gcaaatgtcttccgaggaaggcataagaaaactggtgatctctatgctgtcaaagtattt
aataacataagcttccttcgcccagtggatgttcaaatgagagaatttgaagtgttaaaa
aaactcaatcacaaaaacattgtcaagttatttgctattgaagaggagacaacaacaaga
cataaagtgcttattatggagttttgtccctgtgggagtttatacactgttctagaggag
ccgtccaatgcgtatggacttccagaatcagaatttctcattgtcttacgagatgtggtg
ggcgggatgaatcatctccgagagaacggcatagtgcaccgagatatcaagccaggcaac
atcatgcgcgtcataggggaggacggccagtctgtgtacaaactcacggatttcggcgcc
gctcgagagctggaggacgatgagcagtttgtgtctctgtacggcacagaagagtacctg
catccggacatgtatgaaagggcagtgctaagaaaggaccatcagaagaagtacggggct
accgttgatctgtggagtgttggagtgacattctaccatgcagccacggggtcgctgccg
tttagacccttcgaggggcctcggaggaacaaagaagtaatgtataaaataatcactggg
aagccgtctggtgcaatatctggagtacagaaagcagaaaacggaccaattgactggagt
ggagacatgcctctctcctgtagtctttctcagggtcttcaggcactgcttaccccagtt
cttgcaaacatacttgaagctgatcaggagaagtgctggggttttgaccagttctttgca
gagaccagtgatgtgcttcaccgaatggtgatccatgtcttctcgctacaacacatgacg
gcgcataagatttacattcacagctataacactgctgctgtgttccatgaactggtctat
aaacaaaccaagattgtttcctcaaatcaagaacttatctacgaaggacgacgcttagtc
ctagaactcggacgactagcccagcattttcctaaaaccacagaggaaaatcctatcttt
gtcacgagccgggaacaactcaataccgtaggactgagatatgaaaaaatttccctccct
aaaatacatccacgctatgatctggatggggacgccagcatggccaaggcagtgacgggg
gttgtgtgctacgcctgcagaactgccagtaccctgctgctctatcaagaattaatgcga
aagggggtacggtggctggttgaactggttaaggatgattacaacgagaccgtccacaag
aagacggaggtagtgatcacactggatttctgcatcaggaacattgagaagactgtgaaa
gtgtatgagaagttgatgaaggtcaacctggaagccgcagagctgggtgagatttcagac
atacacaccaagctgctgagactttccagttctcagggaacaatagaaagcagtcttcag
gacatcagcagcaggctgtctccagggggcttgctggccgacacctgggcacatcaagaa
ggcacgcatccaagagacaggaatgtagaaaaactgcaggtcctgttgaactgcatcaca
gagatttactatcagttcaaaaaagacaaagcagaacgcagactagcttataatgaagaa
cagatccacaaatttgataagcaaaaattgtattaccatgccacaaaagcaatgagccac
ttctcagaagaatgtgttagaaagtatgaagcgtttaaagataagtcggaagagtggatg
agaaagatgcttcatcttaggaagcagctgttatcgctaactaatcagtgtttcgatatc
gaagaggaagtgtccaagtatcaagactatactaacgagttacaagaaactctgcctcag
aaaatgctcgcagcctccggcggcgtcaagcacgccatggccccgatctaccccagctct
aacaccttagtggagatgactcttggtatgaagaagttaaaggaggagatggaaggcgtg
gttaaggagctggccgagaacaatcatattttagaaaggtttgggtctttaacaatggat
ggtggccttcgcaatgtggactgtctttag

  All links  
Gene (8)   
   RefGene (3)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (4)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (21)   
   RefSeq(nuc) (1)   
   GenBank (10)   
   EMBL (10)   
3D Structure (3)   
   PDB (3)   
Protein domain (10)   
   Pfam (10)   
All databases (46)   

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