KEGG   Mus musculus (house mouse): 56508
Entry
56508             CDS       T01002                                 
Symbol
Rapgef4, 1300003D15Rik, 5730402K07Rik, 6330581N18Rik, EPAC_2, Epac-2, Epac2, mKIAA4040
Name
(RefSeq) Rap guanine nucleotide exchange factor (GEF) 4
  KO
K04351  Rap guanine nucleotide exchange factor 4
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu04015  Rap1 signaling pathway
mmu04024  cAMP signaling pathway
mmu04072  Phospholipase D signaling pathway
mmu04081  Hormone signaling
mmu04261  Adrenergic signaling in cardiomyocytes
mmu04670  Leukocyte transendothelial migration
mmu04911  Insulin secretion
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    56508 (Rapgef4)
   04072 Phospholipase D signaling pathway
    56508 (Rapgef4)
   04024 cAMP signaling pathway
    56508 (Rapgef4)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    56508 (Rapgef4)
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    56508 (Rapgef4)
  09152 Endocrine system
   04911 Insulin secretion
    56508 (Rapgef4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    56508 (Rapgef4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmu04131]
    56508 (Rapgef4)
Membrane trafficking [BR:mmu04131]
 Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   Rab associated proteins
    56508 (Rapgef4)
SSDB
Motif
Pfam: RasGEF cNMP_binding DEP RasGEF_N RA_2
Other DBs
NCBI-GeneID: 56508
NCBI-ProteinID: NP_001191094
MGI: 1917723
Ensembl: ENSMUSG00000049044
UniProt: Q9EQZ6 A2ASW4 Q571A8
Structure
Position
2:71811559..72087818
AA seq 1011 aa
MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGY
YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN
TPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT
PLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTE
LVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLP
TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHL
STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD
FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV
PAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVF
MPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMA
FLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK
RQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEK
VVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQM
TTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKR
VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM
DPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART
VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
NT seq 3036 nt   +upstreamnt  +downstreamnt
atggtcgctgcgcacgctgcacactctcagtcctcggccgagtggatcgcctgcctggat
aaaaggccgttggagcgatctagtgaagatgtggacataattttcacgcggctgaaagga
gttaaagcttttgagaaatttcacccaaacctccttcgtcagatttgtttatgcggttac
tatgagaacctggaaaaaggaatcacactgtttcgccaaggggatattggaaccaactgg
tatgctgtcctggctgggtctttggatgttaaagtgtctgagaccagcagtcaccaggat
gcggtgaccatctgcactctgggaattgggacagcctttggagagtccattctggataac
acccctcgccatgcaaccatcgttaccagggagagcagcgaacttctccgcattgagcag
gaggacttcaaggcactatgggagaaataccgacagtatatggccggacttctggctcct
ccctatggtgttatggaaacgggctctaacaatgacaggattcctgacaaggagaataca
cctctcattgaaccccacgttcctctccgtcctgctcacaccattaccaaggtcccttca
gagaagatcctcagagctggaaaaattttacgaattgccattctctctcgagctccccac
atgataagagacagaaagtaccacctaaagacatacagacaatgctgtgttgggactgag
ctggtagactggatgatacagcagacatcctgtgttcactcgcggactcaagctgttggc
atgtggcaagtcttgctggaagatggtgtcctcaaccatgtggaccaggagcgccatttc
caagacaaatatttattttatcgatttctggatgacgagcgtgaggatgcccctttgcct
actgaggaagagaagaaggagtgtgatgaagaacttcaggacaccatgctgctgctctca
cagatgggccctgacgcccacatgagaatgatcctgcgaaaaccacctggccagaggact
gtggatgacctagagattatctacgacgagctccttcatattaaagccttatcccatctc
tctaccacagtgaaacgggagttagcaggtgttctcatttttgagtctcacgccaaagga
ggaactgtgttgtttaaccagggggaagaaggtacctcctggtacatcattctgaaagga
tccgtgaatgtagtcatttatggcaagggtgtggtctgcaccctgcacgaaggagatgac
tttggcaagttagctctagtgaacgatgctccaagagctgcctccattgttcttcgggaa
gataattgtcacttcctaagagtcgacaaggaagacttcaatcggattctgagggacgtt
gaggcgaatacagtcagacttaaagaacatgaccaagatgtcttggtactggagaaggtc
ccagcagggaacagagctgctaatcaaggaaactcacagcctcagcaaaagtatactgtg
atgtcaggaacacctgaaaagattttagagcattttctagaaacaatacgccttgagcca
tcgttgaatgaagcaacagattcggttttaaatgactttgttatgatgcactgtgttttt
atgccaaatacccagctttgccctgcccttgtggcccattaccacgcacagccttctcaa
ggtaccgagcaggagagaatggattatgccctcaacaacaagaggcgggtcatccgcttg
gtcctgcagtgggcggccatgtatggcgatctcctccaagaagatgatgtggccatggcc
ttcctggaggagttctatgtgtctgtatcagatgacgcacggatgatggctgccttcaag
gagcagctgccagagctggagaagattgtcaagcaaatctcagaagacgcaaaagctcca
cagaagaagcacaaggtgcttttgcaacagttcaacacaggtgacgagagggcccagaag
cgtcagcctattcgtggctctgatgaggttttgttcaaggtctactgcatcgaccacacc
tatactaccattcgtgtgccggtagctgcctcggtgaaggaagtcatcagtgcagtagct
gacaaactgggctcaggggaaggcctgatcatcgtcaagatgaactctggaggagaaaag
gtggtgctgaaatctaatgatgtttcagtatttacgacgctcaccattaatggacgcctg
tttgcctgcccgagagagcaattcgactcactgactcccttgccggaacaggaaggcccg
accactgggacagtgggaacatttgagctgatgagctcgaaagacctggcgtaccagatg
acaacctacgattgggaactcttcaactgtgtgcatgagctggagctaatctaccacaca
tttggaaggcataattttaaaaagaccacggcaaacttggatttgttcctgaggaggttt
aatgaaattcagttttgggttgtcactgaggtctgcctttgttcccagctcagcaaacgt
gttcagcttttgaaaaaatttatcaagatagcggctcactgcaaggagtacaaaaatcta
aattcctttttcgccatcgtcatgggactcagcaacgtggccgtgagccgcttggcacta
acgtgggagaaactgccgagcaagtttaagaagttctatgcggagtttgagagcttgatg
gatccttccagaaaccacagggcatacaggctgacagcagccaagctggagccccctctc
atccctttcatgcccttgcttattaaagatatgacatttactcatgaggggaacaagacg
ttcattgacaatctagtaaactttgaaaaaatgcgcatgattgcaaacactgccagaaca
gtacggtactacaggagccagcccttcaatccggatgccgctcaagctaataagaaccat
caggatgtccggagttatgtacggcaattaaatgtgattgacaaccagagaactttatca
cagatgtcacacagattagagcctcgaaggccatag

  All links  
Gene (11)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (12)   
   UniProt (3)   
   SWISS-PROT (1)   
   RefSeq(pep) (8)   
DNA sequence (40)   
   RefSeq(nuc) (8)   
   GenBank (16)   
   EMBL (16)   
3D Structure (9)   
   PDB (9)   
Protein domain (5)   
   Pfam (5)   
All databases (77)   

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