KEGG   Mus musculus (house mouse): 66725
Entry
66725             CDS       T01002                                 
Symbol
Lrrk2, 4921513O20Rik, 9330188B09Rik, D630001M17Rik, Gm927, cI-46
Name
(RefSeq) leucine-rich repeat kinase 2
  KO
K08844  leucine-rich repeat kinase 2 [EC:2.7.11.1]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu05012  Parkinson disease
mmu05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    66725 (Lrrk2)
   05022 Pathways of neurodegeneration - multiple diseases
    66725 (Lrrk2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mmu01001]
    66725 (Lrrk2)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmu04131]
    66725 (Lrrk2)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:mmu04147]
    66725 (Lrrk2)
Enzymes [BR:mmu01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     66725 (Lrrk2)
Protein kinases [BR:mmu01001]
 Serine/threonine kinases: TKL group
  LRRK family
   66725 (Lrrk2)
Membrane trafficking [BR:mmu04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    66725 (Lrrk2)
Exosome [BR:mmu04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   66725 (Lrrk2)
SSDB
Motif
Pfam: ARM_LRRK2 Beta-prop_LRRK2 ANK_LRRK2 Pkinase PK_Tyr_Ser-Thr LRR_8 LRR_4 Roc COR-B Ras COR-A LRR_1 LRR_14 WD40_CDC20-Fz Beta-prop_RSE1_2nd WDR55 Beta-prop_WDR36-Utp21_1st LRR_NXF1-5 Arf LRR_9 Beta-prop_EML_2 Ank_2 ABC_tran LRR_13 T2SSE AAA_22 Ank_3 PduV-EutP Beta-prop_WDR5 MMR_HSR1 nSTAND3 GTP_EFTU G-alpha AAA_16 AAA_7 Kdo Arm TniB MobB WD40_Prp19 WD40_WDHD1_1st NACHT AAA_29 NB-ARC FtsK_SpoIIIE TrwB_AAD_bind cobW AAA_18 nSTAND_NTPase5 Ank_5 LRR_6 ARM_CUL7_CUL9
Other DBs
NCBI-GeneID: 66725
NCBI-ProteinID: NP_080006
MGI: 1913975
Ensembl: ENSMUSG00000036273
UniProt: Q5S006 Q9CQG8
Position
15:91556994..91700327
AA seq 2527 aa
MASGACQGCEEEEEEEALKKLIVRLNNVQEGKQIETLLQLLEDMLVFTYSDRASKLFEDK
NFHVPLLIVLDSYMRVASVQQAGWSLLCKLIEVCPGTLQSLIGPQDIGNDWEVLGIHRLI
LKMLTVHHANVNLSIVGLKALDLLLDSGKLTLLILDEECDIFLLIFDAMHRYSANDEVQK
LGCKALHVLFERVSEEQLTEFVENKDYTILLSTFGSFRRDKEIVYHVLCCLHSLAVTCSN
VEVLMSGNVRCYNLVVEAMKAFPTNENIQEVSCSLFQKLTLGNFFNILVLNEVHVFVVKA
VRQYPENAALQISALSCLALLTETIFLNQDLEERSETQEQSEEEDSEKLFWLEPCYKALV
RHRKDKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKDVFQAA
AHALSTLLEQNVNFRKILLAKGVYLNVLELMQKHAHAPEVAESGCKMLSHLFEGSNPSLD
TMAAVVPKILTVMKAHGTSLSVQLEALRAILHFVVPGLLEESREDSQCRPNVLRKQCFRT
DIHKLVLVALNRFIGNPGIQKCGLKVISSLAHLPDATETLSLQGAVDSVLHTLQMYPDDQ
EIQCLGLHLMGCLMTKKNFCIGTGHLLAKILASTLQRFKDVAEVQTTGLQTTLSILELSV
SFSKLLVHYSFDVVIFHQMSSSVVEQKDEQFLNLCCKCFAKVAVDDELKNTMLERACDQN
NSIMVECLLLLGADANQVKGATSLIYQVCEKESSPKLVELLLNGGCREQDVRKALTVSIQ
KGDSQVISLLLRKLALDLANNSICLGGFGIGKIDPSWLGPLFPDKSSNLRKQTNTGSVLA
RKVLRYQMRNTLQEGVASGSDGKFSEDALAKFGEWTFIPDSSMDSVFGQSDDLDSEGSES
SFLVKRKSNSISVGEVYRDLALQRCSPNAQRHSNSLGPVFDHEDLLRRKRKILSSDESLR
SSRLPSHMRQSDSSSSLASEREHITSLDLSANELKDIDALSQKCCLSSHLEHLTKLELHQ
NSLTSFPQQLCETLKCLIHLDLHSNKFTSFPSFVLKMPRITNLDASRNDIGPTVVLDPAM
KCPSLKQLNLSYNQLSSIPENLAQVVEKLEQLLLEGNKISGICSPLSLKELKILNLSKNH
IPSLPGDFLEACSKVESFSARMNFLAAMPALPSSITSLKLSQNSFTCIPEAIFSLPHLRS
LDMSHNNIECLPGPAHWKSLNLRELIFSKNQISTLDFSENPHVWSRVEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDGLHLNFDFKHVGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKMKKPELGMQGATVGIDVRDWSIQI
RGKRRKDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKACISKITKELLNKRGFPTIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKAVPTEFPVINRKHLLQLVNEH
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVDGCLK
HPKGIISRRDVEKFLSKKKRFPKNYMMQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPFMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNRPESFLKITVPSCRKGCILLGRVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDELMKKAEEGDLLINPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEEAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLHDIWTTGSRIMEGLRFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLITKCLKENPQERPTSAQVFDILNSAELICLMRHILIPKNIIVECMVATNL
NSKSATLWLGCGNTEKGQLSLFDLNTERYSYEEVADSRILCLALVHLAAEKESWVVCGTQ
SGALLVINVEEETKRHTLEKMTDSVTCLHCNSLAKQSKQSNFLLVGTADGNLMIFEDKAV
KCKGAAPLKTLHIGDVSTPLMCLSESLNSSERHITWGGCGTKVFSFSNDFTIQKLIETKT
NQLFSYAAFSDSNIIALAVDTALYIAKKNSPVVEVWDKKTEKLCELIDCVHFLKEVMVKL
NKESKHQLSYSGRVKALCLQKNTALWIGTGGGHILLLDLSTRRVIRTIHNFCDSVRAMAT
AQLGSLKNVMLVLGYKRKSTEGIQEQKEIQSCLSIWDLNLPHEVQNLEKHIEVRTELADK
MRKTSVE
NT seq 7584 nt   +upstreamnt  +downstreamnt
atggccagtggcgcctgtcagggctgcgaagaggaagaggaggaggaggctctgaagaag
ttgatagtcaggctgaataatgtccaggaaggcaagcagatcgagacgttgcttcagctc
ctggaggacatgctggtgttcacctactcggaccgcgcctccaagttatttgaagataaa
aatttccacgtgcctctgttgattgtcctggactcctacatgagagttgccagtgtacag
caggcggggtggtcacttctgtgcaaattaatagaagtctgtccagggacattgcaaagc
ttaataggaccccaggatattggaaatgattgggaagtccttggtattcaccggctgatt
cttaaaatgttaactgttcatcacgccaatgtaaacctgtcaatagttggactaaaagcc
ttggatctcctcctagattcaggtaaactcaccttgctgatactggatgaagaatgtgat
attttcttgttaatttttgatgccatgcacagatattcagccaatgatgaagtccaaaaa
ctgggatgcaaagctttacacgtgctttttgagagagtttccgaggaacagctgactgag
tttgtggagaacaaagattacacgatactgctgagtacgttcggcagcttcagaagggac
aaggagattgtgtaccacgtactttgctgcttgcattccctggcggttacatgcagcaat
gtagaggtcctcatgagtgggaatgtccggtgctacaatcttgtggtggaggccatgaaa
gccttccccaccaatgaaaacatccaagaggtgagctgctccttgttccagaagcttaca
ttaggtaactttttcaacatcctggtgttgaacgaagtgcatgtctttgtggtgaaagcg
gtccgacagtatcctgagaacgcagccttacagatctctgcactcagctgtttagcactc
ctcactgagactattttcttaaaccaagacttggaggaaagaagtgagactcaagagcag
agcgaagaggaagacagtgagaagcttttctggctggaaccctgctataaagccctggtg
cgccatcgaaaggacaaacacgtgcaggaggctgcctgctgggcactaaataacctcctt
atgtaccagaacagtttgcatgagaagatcggagatgaagatggccagttccctgcgcac
agggaagtgatgctgtctatgctgatgcactcttcttccaaagatgtcttccaagcagct
gcacatgctctgtccactctcttggaacaaaatgttaatttcaggaaaatcctgctggca
aaaggagtatacctgaatgtcttggaattgatgcagaagcatgcccatgcgcctgaggtg
gcagagagtggctgcaagatgctgagtcacctgtttgaaggaagtaacccttctctggat
acaatggcagcagtggtccctaaaatactaacagtgatgaaagcccacggaacgtctctg
tcagtccagctggaggcgctgcgagctatcttgcatttcgttgtgccaggactattggaa
gaatccagggaggactctcaatgcagaccaaatgtgctcagaaaacagtgtttcaggact
gacatccacaagctggttctagtcgctctgaacaggttcattgggaatcctgggattcag
aaatgtggattgaaagtaatctcttctctcgcgcaccttcctgatgccacagagacattg
tccctgcaaggagcagttgactcagtcctccacaccttacagatgtatccagatgaccaa
gaaattcagtgtctgggcttacaccttatgggatgcttgatgacaaagaagaatttctgc
atagggacagggcacctcctggcaaaaattctggcttccactttgcagcgctttaaagat
gttgctgaggtgcagactacaggattacagacaaccctgtcaatacttgagctgtcagta
tctttctccaagctgctagtgcactattcctttgatgtggtgatatttcatcagatgtct
tccagtgttgtagaacaaaaggatgagcagttcctcaatctatgttgcaaatgctttgca
aaagtggccgtggatgatgagctgaaaaacaccatgctagagagagcctgcgatcagaat
aacagcatcatggttgaatgtttgctcctcttgggagctgatgccaaccaagtgaagggg
gcaacttctttaatctatcaggtatgtgagaaagagagcagtcctaaattggtggaactg
ttgcttaatggtggttgtcgtgaacaagatgtacggaaggccctgaccgtaagcatccaa
aagggcgacagccaggtcatcagcttgctcctcaggaaacttgccctggacctggccaac
aacagcatttgccttggaggatttggcataggaaaaattgatccttcttggcttggtcct
ttatttccagataagtcatccaatttaaggaagcaaacaaacacaggatctgtcctagcg
aggaaagtgctccggtatcagatgagaaacacccttcaagaaggcgtggcctcaggcagt
gacggcaagttttctgaagacgcgctggcgaaatttggagaatggacctttattcccgac
tcttctatggacagtgtgtttggccagagcgatgatctggatagcgaaggcagcgagagc
tcatttctcgtgaagaggaagtccaactcaattagtgtaggggaagtttacagagatcta
gctctgcagcgctgctcaccaaatgctcagaggcattccaattcgctgggtcctgttttt
gaccatgaagacttactgagacgaaaaagaaaaatactgtcttcagatgagtctctcagg
tcctcaaggctgccgtcccatatgaggcaatcagatagctcttcttccctggcttctgag
agagaacacatcacgtcgttagacctatctgccaacgaactcaaagatattgatgctctg
agccagaagtgttgcctcagtagccacctggaacatctcaccaaactggaacttcaccag
aattcactcacgagcttcccacagcagctgtgtgagactctgaagtgtttgatacacttg
gatttgcacagtaacaaattcacctcatttccctctttcgtgttgaaaatgccacgtatc
accaacctagatgcctctcgaaatgacatcgggccaacagtagttttagaccctgcgatg
aagtgtccaagcctcaaacagttgaatctgtcctataaccagctctcttcaatcccagag
aatcttgcccaagtggtggagaaacttgagcagctcctactggaaggaaataaaatatcc
gggatttgctctcccctgagcctgaaggaactgaagattttaaatcttagtaaaaatcac
attccatccctacctggagattttcttgaggcttgttcaaaagtcgagagtttcagtgct
cgcatgaattttcttgctgcaatgcctgccttaccttcttccataacgagcttaaaattg
tctcagaactctttcacgtgcattccagaagcgattttcagtcttccgcacttgcggtcc
ttggatatgagccacaacaacattgaatgtctgccgggacctgcacattggaagtctctg
aacttaagggaactcatttttagcaagaatcagatcagcaccttagactttagtgagaac
ccacacgtgtggtcaagagtagagaaactgcatctctctcataataaactgaaagagatt
cctccagaaattggctgccttgaaaatctgacgtctctcgacgtcagttacaacttggaa
ctgaggtccttcccaaatgaaatggggaagttgagcaagatatgggatcttcccttggac
ggactgcatctgaattttgactttaagcacgtaggatgcaaggccaaagacatcataagg
tttctacaacaacgtctgaaaaaggctgtaccctacaaccgaatgaagctcatgattgtg
ggaaatacggggagcggtaagaccactttactgcaacaactcatgaaaatgaagaaacca
gaacttggcatgcagggtgccacagtcggcatagacgtgcgagactggtccatccaaata
cggggcaaaaggagaaaggacctggttctaaacgtgtgggattttgcaggtcgtgaggaa
ttctacagcactcacccccacttcatgacccagagagccctctacctggctgtctatgat
ctcagcaaggggcaggcagaggtggacgccatgaagccctggctcttcaatatcaaggct
cgtgcctcttcttccccggtgattctggtgggcacacatttggatgtttctgatgagaag
cagcggaaagcgtgcataagcaaaatcacgaaggaactcctaaataagcgaggattcccc
accatccgggactaccactttgtgaatgccaccgaggagtcagatgcgctggcaaagctt
cggaaaaccatcataaatgagagccttaatttcaagatccgagatcagcctgtggttggg
cagctaattccagattgctacgtagaactggagaaaatcattttatcagagcggaaagct
gtgccgactgagtttcctgtgattaaccggaaacacctgttacagctcgtgaacgaacat
cagctgcagctggatgagaacgagctcccacacgccgttcacttcctaaatgagtcggga
gttcttctgcattttcaagaccctgccctgcagctaagtgacctgtactttgtggaaccc
aagtggctttgtaaagtcatggcacagatcttgacagtgaaggtagacggctgtctgaaa
catcctaagggcatcatttcccggagagatgtggaaaaattcctttcaaagaagaagcga
ttcccgaagaactatatgatgcaatactttaaactattagaaaaatttcagatcgcattg
ccaataggggaagaatatcttctggttccaagcagcttgtctgaccacaggccagtgata
gagctcccccactgtgagaactctgagatcatcatccggctgtacgaaatgccgtacttt
cccatgggattttggtcaagattgattaaccgattacttgaaatctcacccttcatgctt
tctggcagagagagagcactacgccctaacaggatgtattggcggcaaggcatctacttg
aattggtctccagaagcatactgtctggtaggctctgaagtcttagacaatcgacctgag
agtttcttgaaaatcacagttccgtcttgtagaaaaggttgtattcttctgggccgagtt
gtggatcatattgactcactcatggaagaatggtttcccgggttactggagattgacatt
tgtggggaaggagaaactctgttgaagaaatgggcattgtacagttttaatgatggtgaa
gaacatcagaagatcttgcttgatgagttgatgaagaaggctgaagaaggagacctgtta
ataaatccagaccaaccaaggctcactattccaatatcccagattgctccggacttgatc
ttggctgacctgcctagaaatatcatgttgaacaatgatgagttggaatttgaggaagca
ccagagtttctcttaggcgatggaagttttggatccgtttatcgagctgcctacgaagga
gaggaagtggctgtgaagatttttaataagcacacatctcttaggctgttaagacaagag
ttggtggtcctttgtcaccttcaccaccccagcctgatatccttgctggcggctggtatt
cgtcctcggatgttggtaatggagttggcctccaaaggttccttggatcgcctgctgcag
caggacaaagccagcctcaccagaaccctccagcacaggatcgcgttgcatgtggccgac
ggcctgaggtatctccactcagccatgattatttaccgtgacctgaagccccacaatgtg
ctgctttttaccctgtatcccaatgctgccatcattgcgaagattgcggactacgggatc
gcacagtactgctgcaggatgggaataaagacatcagagggcaccccagggttccgggca
cctgaagttgccagggggaatgtcatttataaccaacaggccgatgtttattcttttggc
ttactacttcacgatatttggacaactgggagtaggattatggagggtttgaggttccca
aatgagtttgatgagttagccatacaagggaagttgccagatccagttaaagaatatggc
tgtgccccatggcctatggttgagaagttaattacaaagtgtttgaaagaaaatcctcaa
gaaagacccacttctgcccaggtctttgacattttgaattcggctgaattaatttgcctc
atgcgacacattttaatacctaagaacatcattgttgaatgcatggttgccacgaatctc
aatagcaagagtgcgactctctggttgggatgtgggaacacagaaaaaggacagctttcc
ttatttgacttaaacacggaaagatacagctatgaggaagttgctgatagtagaatactg
tgcttggctttggtgcatctcgctgctgagaaagagagctgggttgtgtgcgggacacag
tctggggctctcctggtcatcaatgttgaagaggagacaaagagacacaccctggaaaag
atgactgattctgtcacttgtttgcattgcaattcccttgccaagcagagcaagcaaagt
aactttcttttggtgggaactgctgatggtaacttaatgatatttgaagataaagccgtt
aagtgtaaaggagctgcccccttgaagacactacacataggcgatgtcagtacgcccctg
atgtgcctgagcgagtccctgaattcatctgaaagacacatcacatggggagggtgtggc
acaaaggtcttctccttttccaatgatttcaccattcagaaactcatcgagacaaaaacc
aaccagctgttttcttacgcagctttcagcgattctaacatcatagcgctggcagtagac
acagccctgtatattgccaagaaaaacagccctgtcgtagaggtgtgggacaagaaaaca
gaaaagctctgtgaattaatagactgtgtgcacttcttaaaggaggtgatggtaaaacta
aacaaggaatcgaaacatcagctgtcctactctgggagggtgaaggccctctgcctgcag
aagaacacggctctctggatcggaactggaggaggccacatcttactcctggatctttct
actcggcgagttatccgcaccattcacaatttctgtgattctgtgagagccatggccaca
gcacaattaggaagccttaagaatgtcatgctggttttggggtacaagcggaagagtaca
gagggtatccaagaacaaaaagagatacaatcttgtttgtctatttgggacctcaatctt
ccacacgaggtgcaaaatttagaaaaacacattgaagtaagaacagaattagctgataaa
atgaggaaaacatctgttgaatag

  All links  
Gene (47)   
   RefGene (41)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (2)   
   OC (1)   
Protein sequence (6)   
   UniProt (2)   
   SWISS-PROT (1)   
   RefSeq(pep) (3)   
DNA sequence (26)   
   RefSeq(nuc) (4)   
   GenBank (11)   
   EMBL (11)   
Protein domain (52)   
   Pfam (52)   
All databases (131)   

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