KEGG   Mus musculus (house mouse): 74055
Entry
74055             CDS       T01002                                 
Symbol
Plce1, 4933403A21Rik, PLCepsilon, Plce, mKIAA1516
Name
(RefSeq) phospholipase C, epsilon 1
  KO
K05860  phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
Organism
mmu  Mus musculus (house mouse)
Pathway
mmu00562  Inositol phosphate metabolism
mmu01100  Metabolic pathways
mmu04014  Ras signaling pathway
mmu04015  Rap1 signaling pathway
mmu04020  Calcium signaling pathway
mmu04024  cAMP signaling pathway
mmu04070  Phosphatidylinositol signaling system
mmu04919  Thyroid hormone signaling pathway
mmu04933  AGE-RAGE signaling pathway in diabetic complications
mmu05205  Proteoglycans in cancer
Module
mmu_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mmu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    74055 (Plce1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    74055 (Plce1)
   04015 Rap1 signaling pathway
    74055 (Plce1)
   04020 Calcium signaling pathway
    74055 (Plce1)
   04070 Phosphatidylinositol signaling system
    74055 (Plce1)
   04024 cAMP signaling pathway
    74055 (Plce1)
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    74055 (Plce1)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    74055 (Plce1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    74055 (Plce1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mmu04131]
    74055 (Plce1)
Enzymes [BR:mmu01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     74055 (Plce1)
Membrane trafficking [BR:mmu04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    74055 (Plce1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    74055 (Plce1)
SSDB
Motif
Pfam: PI-PLC-X PI-PLC-Y RasGEF RA C2 EF-hand_like GDPD
Other DBs
NCBI-GeneID: 74055
NCBI-ProteinID: NP_062534
MGI: 1921305
Ensembl: ENSMUSG00000024998
UniProt: Q8K4S1
Position
19:38469438..38773549
AA seq 2282 aa
MTSEEMAASVLIPVTQRKVASAQSVAEERSVKVSDAGIPRARAGRQGALIPPTISQWNKH
KEESSRSDLSKVFSIARGELVCDENSNEEGWEENAPDSPENHAMNGNSLVQSHQHQFPRS
QLCEARDSVTEDPCLQPGIPSPLERKVLPGIQLEMEDSPMDVSPAGSQPRIMESSGPHSD
RNTAVFHFHYEADRTMSDAFHTLSENLILDDCANCVTLPGGQQNKNCMAYACKLVELTRT
CGSKNGQVQCEHCTSLRDEYLCFESSCSKADEVCSGGGFCEDGFAHGPAAKTFLNPLEDF
SDNCEDVDDFFKSKKERSTLLVRRFCKNDREVKKSVYTGTRAIMRTLPSGCIGPAAWNYV
DQKKAGLLWPCGNVMGTLSAMDIRQSGSQRLSEAQWCLIYSAVRRGEEIEDTVGSLLHCS
TQLPNSETAHGRIEDGPCLKQCVRDTECEFRATLQRTSIAQYITGSLLEATTSLGARSGL
LSSFGGSTGRIMLKERQLGTSMANSNPVPSSSAGISKELIDLQPLIQFPEEVASILTEQE
QNIYRRVLPMDYLCFLTRDLSSPECQRSLPRLKASISESILTSQSGEHNALEDLVMRFNE
VSSWVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSRKVLKMWQFM
DQSDIETMRSLKDAMAQHESSVEYKKVVTRALHIPGCKVVPFCGVFLKELCEVLDGASGL
LKLCPRYSSQEEALEFVADYSGQDNFLQRVGQNGLKNSEKELTVNSIFQVIRSCSRSLEM
EEEDSASEGSGSRKNSLKDKARWQFIIGDLLDSENDIFEKSKECDPHGSEESQKAFDHGT
ELIPWYVLSIQADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWMKPPTASPAG
ARPKLGVLSNMAEPGKFPSPGNAGVSGLAEGILDLFSVKAVYMGHPGIDIHTVCVQNKLS
SMLLSETGVTLLYGLQTTDNRLLHFVAPKHTAEMLFSGLLELTTAVRKIRRFPDQRQQWL
RKQYVSLYQEDGRYEGPTLAHAVELFGGRRWSTRNPSPGMSAKNAEKPNMQRNNTLGIST
TKKKKKMLMRGESGEVTDDEMATRKAKMYRECRSRSGSDPQDVNEQEESEANVITNPPNP
LHSRRAYSLTTAGSPNLATGMSSPISAWSSSSWHGRIRGGMQGFQSFMVSDSNMSFVEFV
ELFKSFSIRSRKDLKDIFDIYSVPCNRSASESAPLYTNLTIEENTSDLQPDLDLLTRNVS
DLGLFIKSKQQLSDNQRQISDAIAAASIVTNGTGIESTSLGIFGVGILQLNDFLVNCQGE
HCTYDEILSIIQKFEPSVSMCHQGLLSFEGFARFLMDKDNFASKNDESRENKKELQLPLS
YYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSIELDCWDGDDGMPIIYHGHTLTTK
IPFKEVVEAIDRSAFITSDLPIIISIENHCSLPQQRKMAEIFKSVFGEKLVAKFLFETDF
SDDPMLPSPDQLRRKVLLKNKKLKAHQTPVDILKQKAHQLASMQAQAFTGGNANPPPASN
EEEEDEEDEYDYDYESLSDDNILEDRPENKSCADKLQFEYNEEVPKRIKKADNSSGNKGK
VYDMELGEEFYLPQNKKESRQIAPELSDLVIYCQAVKFPGLSTLNSSGSSRGKERKSRKS
IFGNNPGRMSPGETAPFNRTSGKGSCEGMRHTWEESSPLSPSTSLSAIIRTPKCYHISSL
NENAAKRLCRRGSQKLIQHTAYQLLRTYPAATRIDSSNPNPIMFWLHGIQLVALNYQTDD
LPLHLNAAMFEANGGCGYVLKPPVLWDKSCPMYQKFSPLERDLDNLDPAIYSLTIISGQN
VCPSNSTGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFRVHFEDLVFLRFAV
VENNSSAITAQRIIPLRALKRGYRHLQLRNLHNEILEISSLFINSRRMEENPSGSSMPAS
LMFNTEERKCSQTHKVTVHGVPGPEPFAVFTINEGTKAKQLLQQVLAVDQDTKCTATDYF
LMEEKHFISKEKNECRKQPFQRAVGPEEDIVQILNSWFPEEGYVGRIVLKPQQETLEEKS
IVFDDKEVILSSEEESFFVQVHDVSPEQPRTVIKAPRVSTAQDVIQQTLCKAKYSYSILN
NPNPCDYVLLEEVLKDAANKKSSTPKSSQRILLDQECVFQAQSKWKGAGKFILKLKEQVQ
ASREDKRRGISFASELKKLTKSTKQSRGLPSPPQLVASESVQSKEEKPVGALSSSDTVGY
QQ
NT seq 6849 nt   +upstreamnt  +downstreamnt
atgacgtcggaagaaatggccgcttctgtcctcatccctgtgactcaaaggaaagtggct
tctgcccagtcggtggcagaagagaggagtgtaaaggtctcagatgcggggattcctcgg
gcacgtgctggcaggcagggtgcgctcatccctcctaccatctcacagtggaacaaacat
aaggaagagtcgtctagaagtgatttgtccaaggtcttctcaatagcgaggggggaacta
gtctgcgatgagaattccaacgaagagggctgggaggaaaacgcaccggactccccggaa
aaccacgcgatgaacggcaacagtttagtgcaaagccaccagcaccagtttccccggagc
cagctttgtgaagcccgtgactctgtcacagaagacccgtgtttgcagcctggaattcct
tctcccctggaaaggaaggtgctccctggaattcaactggagatggaggactctcccatg
gacgtgagccctgcgggaagtcagcctaggatcatggagtccagcggacctcactctgac
cgcaacacggcggtatttcacttccattatgaagctgacaggacaatgtcggatgctttt
cataccctgtcagaaaacctgattttggatgactgtgcaaattgtgttactcttcctggg
gggcagcaaaataaaaattgcatggcgtatgcttgcaaactggtggagttgacaagaacc
tgtggaagtaagaatgggcaagtccagtgtgagcactgtacctcgctgcgcgatgaatac
ctgtgcttcgaaagctcctgctcaaaggccgatgaggtctgctcaggtggtggcttttgc
gaggacggctttgctcacggtcctgctgccaagacttttctgaaccctctggaggatttc
tctgacaattgtgaagacgtagacgatttttttaaaagcaaaaaggagcggtccacgttg
ttagtccgaaggttttgtaaaaatgacagggaagttaagaagtctgtgtatactgggacc
agagccatcatgagaactctgccttctggctgtattgggccagctgcttggaattacgtt
gatcagaagaaagctggtctcctatggccttgtgggaatgtaatgggaactctgtcagca
atggacataaggcaaagtgggagccaacgtctgtctgaagcccagtggtgcctgatctac
agtgccgtgagaagaggggaagaaatagaagatacggttggatctcttctccattgctcc
acacagctcccaaactctgagacagcccatggaaggattgaagatggtccctgcttaaag
cagtgtgtacgagacactgaatgtgaattccgtgctaccctccaaaggacatccatagct
cagtacatcaccggttctcttctagaggcaactacatctttaggagcaagaagtggcctt
ctcagttccttcggaggatccactggacgaataatgctgaaagaacgccaactgggcacc
tctatggccaattccaatcctgttccttcaagttcagctggaatcagcaaggagctgatt
gatctccagcccctcattcagttcccggaggaagtagccagcatcttaacagagcaggaa
cagaacatttaccgcagggtcctgcccatggactacctctgcttcttaacccgggacttg
agttcacctgaatgccagagatcactgccccgtctcaaagcatccatctcagaatccatc
ctcacgtctcaaagtggagaacacaatgcccttgaagaccttgtgatgagatttaacgag
gtgagctcctgggtaacatggctgatcctcacagcaggctccatggaggagaagcgggaa
gtcttttcttatttggtgcatgtggccaaatgctgctggaacatgggcaactacaacgct
gtcatggagttcctggctggcctcaggtcaaggaaagttctaaagatgtggcagttcatg
gaccagtctgacattgagaccatgcggagcctgaaggatgccatggcccagcatgagtct
tccgtggagtacaagaaggtagtgacccgagccttgcacatccccggctgcaaagtggtc
cccttctgtggggtgttcctgaaggagctctgtgaggtgcttgatggtgcctctggcctc
ctgaagctctgcccacggtacagctcccaagaagaagctctggagtttgtagccgattac
agtggacaagataacttcttacaacgagtgggacagaatggcttaaagaattcagagaag
gagctcacggtcaacagcatctttcaggtcatccggagctgcagccgaagtttggagatg
gaggaggaagacagtgccagtgaagggagcggctctaggaaaaactccctgaaggacaaa
gcccgatggcagtttataattggagatttgctggattcagaaaatgacatctttgagaag
tccaaagagtgtgacccccatggatccgaggagtcacagaaagcctttgaccatgggaca
gagcttatcccatggtacgtgctgtccatccaagcagatgtgcaccagttcctattgcag
ggggccacagtcatccactatgaccaggacacacatctctcggcccgctgctttctccag
ttgcagcctgacaatagcacgttgacctggatgaaacctcccactgcctccccagcaggc
gccagacccaagctcggtgtgcttagtaacatggccgagcctggcaagttcccatcccca
ggcaacgccggggtgagcggcctggcagagggaattctggatctgttctcagtgaaggct
gtgtacatgggacaccctggcattgatatacacactgtgtgtgtccagaacaaacttagt
agcatgcttctatcggagacgggggtcacactgctctatgggcttcagaccacggacaat
agattactgcactttgtggcgccaaagcacacggctgagatgcttttcagtggattgctg
gaactcactacagctgtgagaaagataaggaggttccctgaccaacgacagcagtggctt
cggaaacagtatgtcagcctctatcaggaggatggtcggtatgaaggcccaaccttggca
catgctgtggagttgtttggtggtaggcggtggagcactagaaaccccagccctggaatg
tcagcaaagaatgctgagaagcccaacatgcagagaaacaacaccctgggcataagcacc
accaagaaaaagaagaaaatgctcatgaggggagagagtggagaggtgacggacgatgag
atggctacccgcaaggccaaaatgtacagagagtgtcgcagccggagcggctctgatcct
caagacgttaacgaacaagaagagtcggaggccaatgtcatcactaaccctcccaacccc
ctccattccagaagagcctactctttgaccacggctgggtcccccaacttggctaccggg
atgtcatctcccatcagtgcctggagcagcagcagctggcatgggcgaatccgaggagga
atgcaaggcttccagagcttcatggtctcagacagtaacatgagtttcgttgaattcgtc
gagctgttcaaatcattcagcatcaggagccgcaaggacttgaaggacatctttgacatc
tactctgtaccctgcaatcggtctgcctcggagtcagccccactctacaccaacctgaca
atcgaagaaaataccagcgatcttcagcctgacctagatttgctgactagaaacgtctcc
gacctggggctgttcattaaaagtaaacagcagctttctgacaaccagaggcagatatct
gatgctatcgctgctgcaagcatcgtgaccaatggtactgggattgaaagcacgtccctg
ggcatatttggggtcggcatactccagctcaatgacttcctggtgaattgccaaggagaa
cactgcacatatgatgaaatcctgagcatcatccagaaatttgagcctagcgtcagcatg
tgtcatcaaggcctactgtcatttgaagggtttgcaaggtttctgatggataaagacaat
ttcgcctcaaaaaatgatgagtcacgggagaacaagaaagaactgcagctacccctctcc
tactattatatagaatcttcacacaacacctacctcaccggccatcagctcaagggggag
tcctctgtggagctctatagccaggtcctcctgcaaggatgtagaagcatagagctggac
tgctgggacggggatgatgggatgcccatcatctatcatgggcatacactgacaaccaag
atccccttcaaggaagtggtggaagccatcgatcgcagtgccttcatcacctcagacctg
ccaatcatcatatccattgagaaccattgttcattgcctcaacaacgaaaaatggcagaa
attttcaagagtgtgtttggagaaaagctggtggctaagttcttattcgagaccgatttc
tcagatgacccaatgcttccctcacctgatcaacttagaaggaaagtactccttaaaaac
aagaagctaaaggcccatcagacacctgtcgacatcctaaaacaaaaggctcatcagtta
gcatccatgcaagcacaggctttcaccggtgggaatgccaacccgccacctgccagtaat
gaggaagaggaagatgaggaggatgaatatgattacgattacgagtccctgtccgatgac
aatattctggaagacagacctgagaacaaatcatgcgctgacaagcttcagtttgagtac
aatgaagaggtccccaagaggataaagaaagcagacaactcctctggcaataagggaaag
gtgtatgacatggaactgggagaggagttttaccttcctcagaacaaaaaggaaagcagg
cagattgcaccggagctttctgacctcgtcatttattgccaggcagtaaaatttccaggc
ctgtcaactctaaattcatctggctctagcagagggaaagaaaggaaaagcaggaagtcc
atttttggcaacaatcctggcagaatgagccccggggagacagcgccatttaacagaaca
tctggaaaaggttcctgtgaagggatgcgacacacctgggaggaatcttctccactcagc
ccaagcacatccctcagcgctatcatcaggactcctaaatgctatcacatctcctcactg
aacgagaacgccgccaaacgtctgtgccgcaggggttctcagaaactgatccagcacacc
gcttatcagctgctgaggacctacccggcagcgaccagaatcgactcctccaatcccaac
cccatcatgttctggctccatgggatacagcttgtagctctaaactaccaaaccgatgac
cttcctttacatttaaacgccgccatgtttgaggcgaatggtgggtgtggttatgttttg
aagccccctgtcctgtgggataaaagctgtcccatgtaccagaagttttctccactggaa
agagacctagacaacctggatcctgctatctattctttaactatcatctctggccagaat
gtgtgccctagtaacagcaccggaagtccatgcattgaagtcgacgtcttgggcatgccc
ctggacagctgccatttccgcacaaaacccatccatcgaaacactctaaaccccatgtgg
aatgagcagtttctcttccgggttcactttgaagatcttgtatttcttcgttttgcagtc
gtggaaaacaacagttcggcgataacggctcagagaatcattccactcagagctttgaaa
cgaggatatcgacatcttcagctgcggaacctccacaatgaaatcttggaaatctctagc
ttattcataaacagcagaaggatggaagaaaacccctctggcagttccatgccagcctcg
ttgatgtttaatactgaagagaggaaatgttctcagactcacaaagtcacagtgcatggt
gtcccaggtccagagccctttgctgttttcactataaacgaaggcaccaaggcaaagcag
cttctccaacaggttttggcagttgaccaagacaccaaatgtactgccacagactatttt
ttgatggaagagaagcattttatatctaaggaaaagaatgaatgcaggaaacaaccattc
cagagagctgtgggtccagaagaagatattgtgcagattttaaacagttggttcccagaa
gaaggctacgtaggcaggattgtcttaaagccccaacaggaaactctagaagagaaaagc
attgtcttcgacgacaaagaggtgatcttgagctcagaggaggagagtttctttgtgcaa
gtgcatgatgtctctccagagcaacctcgaactgtcatcaaagccccacgtgtcagcact
gcacaggatgtaattcagcagaccttatgcaaagccaaatattcctacagcatcctgaac
aaccccaacccatgtgactatgtgcttttggaagaggtgctgaaagatgcagctaataag
aagtcttctaccccaaagtcctcgcagaggatcctcttggaccaagaatgtgtgtttcaa
gcgcaaagcaagtggaagggtgcgggaaagttcatacttaagctaaaggagcaggtgcag
gcatcccgagaagacaaaaggaggggtatctcctttgcaagtgaactcaagaagctcact
aagtccactaagcagtctcgagggctcccatcacctcctcagcttgtggcctcagaaagt
gttcaaagcaaggaggagaaacctgtgggtgccttgtcctctagtgacacagtgggttac
cagcagtga

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