KEGG   Mycolicibacterium smegmatis MC2 155: MSMEG_0954
Entry
MSMEG_0954        CDS       T00434                                 
Symbol
hemD
Name
(GenBank) uroporphyrinogen-III synthase
  KO
K13542  uroporphyrinogen III methyltransferase / synthase [EC:2.1.1.107 4.2.1.75]
Organism
msm  Mycolicibacterium smegmatis MC2 155
Pathway
msm00860  Porphyrin metabolism
msm01100  Metabolic pathways
msm01110  Biosynthesis of secondary metabolites
msm01120  Microbial metabolism in diverse environments
msm01240  Biosynthesis of cofactors
Module
msm_M00846  Siroheme biosynthesis, glutamyl-tRNA => siroheme
msm_M00926  Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:msm00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    MSMEG_0954 (hemD)
Enzymes [BR:msm01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.107  uroporphyrinogen-III C-methyltransferase
     MSMEG_0954 (hemD)
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.75  uroporphyrinogen-III synthase
     MSMEG_0954 (hemD)
SSDB
Motif
Pfam: HEM4 TP_methylase
Other DBs
NCBI-ProteinID: ABK75236
UniProt: A0QR19
Position
1031413..1033245
AA seq 610 aa
MGGADSLTKVGGADAAVAVVGAAEGSVGAAESPASDPQPRESSSRSRSRKVKPGRITFVG
SGPGDPGLLTTRAQAVLAHAELVFTDPDVPEAVLALVGTDLPPAAGPAPAKKNDKADKAT
DKSDKSDKADKADDAKSDDPAVIPGGPEVRPALGDPAEVAKTLASEARHGYNVVRLIAGD
PLSVDAVITEINALAKTHLTFEIVPGLPDTTAVPTYAGLPLGSSHTVADVRGDVDWAALA
AAPGPLILHATASHLPDAARTLIEHGLVENTPAVVTANGTTCQQRSVETTLVGLTDKTVV
EKPAGSELLGPLTGPLVVTIGKTVANRAKLNWWESRALYGWTVLVPRTKDQAGEMSERLV
THGALPIEVPTIAVEPPRSPAQMERAVKGLVDGRFQWVVFTSTNAVRAVWEKFNEFGLDA
RAFSGVKIACVGQATADKVRAFGINPELVPSGEQSSLGLLDEFPPYDEVFDPVNRVLLPR
ADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPAHTREMIKTGGFDAVCFTSSSTVRNL
VGIAGKPHARTIVACIGPKTAETAIEFGLRVDVQPETAAVGPLVEALAEHAARLRAEGAL
PPPRKKSRRR
NT seq 1833 nt   +upstreamnt  +downstreamnt
atgggcggagccgacagtctcaccaaggtgggcggtgccgacgctgcggttgcggtggtc
ggtgcggccgagggttcggtcggtgcggccgagagcccggcgtccgaccctcagccgcgt
gagagctcgagccggtcgcgcagccgcaaggtcaagcccggtcgcatcacgttcgtcggt
tcgggccccggtgacccgggcctgctgaccaccagggcgcaggccgtgctcgcgcatgcc
gagctggtcttcaccgatcccgatgtgcccgaggcggtgctcgccctcgtcggcaccgat
ctgcccccggcggcgggtccggcgcccgccaagaagaacgacaaggccgacaaggccacc
gacaagtcggacaagtccgacaaggccgacaaggccgatgacgccaagtccgacgatccg
gcggtcatccccggcggacccgaggtgcgtcccgcgctcggcgacccggccgaggtcgcc
aagacgctcgcgtccgaggcgcgccacggatacaacgtcgtgcgcctgatcgcgggtgac
ccgctgtcggtggatgccgtgatcaccgagatcaacgcactggccaagacgcatctgacc
ttcgagatcgtcccgggtctgcccgacaccaccgcggttccgacgtacgccggcctgccg
ctggggtcgtcgcacaccgtcgccgacgtgcgtggcgacgtcgactgggccgcactggcg
gccgcgccggggccgctgatcctgcatgcgaccgcgtcgcacctgccggatgccgcccgc
acgctcatcgagcacgggctcgtcgagaacacgcccgcggtcgtcacggccaacggcacc
acctgccagcagcgttcggtcgagaccacgctggtggggctcaccgacaagaccgtggtg
gagaagcccgcgggcagcgagctgttgggcccgctgaccggaccgctggtggtcaccatc
ggcaagaccgtcgccaaccgcgccaagctgaactggtgggagagccgcgccctgtacggc
tggaccgtgctggtgccgcgcaccaaggatcaggccggcgagatgagcgagcggctcgtc
acgcacggcgccctgccgatcgaggtgcccaccatcgccgtcgagccgccgcgcagcccg
gcgcagatggagcgcgcggtcaagggcctggtcgacggccggttccagtgggtcgtgttc
acctccaccaacgccgttcgcgcggtgtgggagaagttcaacgagttcggtctggacgcc
cgcgcgttctccggcgtgaagatcgcctgcgtggggcaggccaccgcggacaaggtgcgc
gcgttcgggatcaatcccgaactggtgccgtcgggcgagcagtcctcgctcggcctgctg
gatgaattcccgccctacgacgaggttttcgacccggtcaaccgtgtgttgctgccgcgt
gcggacatcgccaccgagacgctggccgagggtctgcgtgagcgtggctgggagatcgag
gacgtcacggcgtaccgcaccgtgcgtgcggccccgccgcctgcgcacacccgcgagatg
atcaagaccggtggtttcgacgcggtgtgcttcacgtcgagttcgaccgtgcgcaacctc
gtcggcatcgcgggcaagccgcacgcccgcaccatcgtggcctgcatcggaccgaaaacc
gcagaaaccgcaatcgaattcggtctgcgcgtggatgtgcagcccgagacagccgcggtc
ggaccgctggtcgaggcgctcgccgagcacgccgcccggttgcgcgccgagggtgcgctc
ccgccgccgcgcaagaagagccgccgcaggtaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (10)   
   KEGG PATHWAY (5)   
   KEGG MODULE (5)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG ENZYME (2)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   OC (1)   
Protein sequence (1)   
   UniProt (1)   
Protein domain (2)   
   Pfam (2)   
All databases (29)   

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