KEGG   Mycobacterium tuberculosis CDC1551: MT2216Help
Entry
MT2216            CDS       T00053                                 

Gene name
murF
Definition
(GenBank) UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase
  KO
K01929  UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]
Organism
mtc  Mycobacterium tuberculosis CDC1551
Pathway
mtc00300  Lysine biosynthesis
mtc00550  Peptidoglycan biosynthesis
mtc01100  Metabolic pathways
mtc01502  Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:mtc00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    MT2216 (murF)
  09107 Glycan biosynthesis and metabolism
   00550 Peptidoglycan biosynthesis
    MT2216 (murF)
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01502 Vancomycin resistance
    MT2216 (murF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01011 Peptidoglycan biosynthesis and degradation proteins [BR:mtc01011]
    MT2216 (murF)
Enzymes [BR:mtc01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.10  UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
     MT2216 (murF)
Peptidoglycan biosynthesis and degradation proteins [BR:mtc01011]
 Precursor biosynthesis
  Amino acid ligase
   MT2216 (murF)
BRITE hierarchy
SSDB OrthologParalogGene clusterGFIT
Motif
Pfam: Mur_ligase_M Mur_ligase_C Mur_ligase DUF108 MFS_2
Motif
Other DBs
NCBI-ProteinID: AAK46500
UniProt: P9WJL0
Position
complement(2416164..2417696)
Genome map
AA seq 510 aa AA seqDB search
MIELTVAQIAEIVGGAVADISPQDAAHRRVTGTVEFDSRAIGPGGLFLRLPGARADGHDH
AASAVAAGAAVVLAARPVGVPAIVVPPVAAPNVLAGVLEHDNDGSGAAVLAALAKLATAV
AAQLVAGGLTIIGITGSSGKTSTKDLMAAVLAPLGEVVAPPGSFNNELGHPWTVLRATRR
TDYLILEMAARHHGNIAALAEIAPPSIGVVLNVGTAHLGEFGSREVIAQTKAELPQAVPH
SGAVVLNADDPAVAAMAKLTAARVVRVSRDNTGDVWAGPVSLDELARPRFTLHAHDAQAE
VRLGVCGDHQVTNALCAAAVALECGASVEQVAAALTAAPPVSRHRMQVTTRGDGVTVIDD
AYNANPDSMRAGLQALAWIAHQPEATRRSWAVLGEMAELGEDAIAEHDRIGRLAVRLDVS
RLVVVGTGRSISAMHHGAVLEEAWGSGEATADHGADRTAVNVADGDAALALLRAELRPGD
VVLVKASNAAGLGAVADALVADDTCGSVRP
NT seq 1533 nt NT seq  +upstreamnt  +downstreamnt
atgatcgagctgaccgtcgcgcagatcgccgagatcgtcgggggcgcagtggccgatatc
tccccgcaagacgccgcgcaccgccgcgtcaccgggaccgtcgagttcgactcgcgcgcc
atcggcccgggcgggctgttcctccgcctgccgggggcgcgcgccgacggccacgaccat
gccgcgtcggcggtagccgcgggcgccgccgtcgtgctggccgcccgcccggtgggggtg
ccggccatcgtggttccgccagtggccgcgccgaacgtattggccggcgtcctcgagcac
gacaacgacgggtcgggggcggcggtgctggccgcgctggccaagctggccaccgcggtg
gccgcgcagttggtggccggcgggctcaccatcatcgggatcaccggctcgtcgggcaag
acgtcgaccaaggacctgatggccgccgtgctggccccgctgggggaggtggtggccccg
cccggatcgttcaacaacgagctgggtcacccgtggacggtgctgcgcgcgacgcggcgc
accgactacctgattttggagatggcggcacgccatcacggcaacatcgccgcgctcgcc
gagatcgcgcccccgtcgatcggagtcgtgctcaacgtcggcaccgcacatttgggtgag
ttcggctcccgcgaggtcatcgcacagaccaaagccgaactgccgcaggctgttccgcat
tccggagcggtcgtcctcaacgctgatgaccccgcggtggcggcgatggccaagctgacc
gcggcccgggtggtgcgggtcagccgggacaacaccggtgacgtttgggcggggccggtg
tcgctggacgaattggccaggccgcgctttacgctgcatgcccacgatgcccaagccgag
gtccgactcggggtctgcggcgaccaccaggtcactaacgcgctgtgcgccgcggcggtc
gcgctggagtgtggggccagcgttgaacaggtcgcggccgcgctgaccgcggcgccgccg
gtgtcgcggcatcggatgcaggtgaccacccgcggcgacggggtgacggtgatcgacgac
gcctacaacgccaaccccgactccatgcgggccgggctgcaggcgctggcctggatcgcg
caccaacccgaggccacccgccgcagctgggcggtgctgggtgagatggccgagctgggt
gaggacgcgatagccgagcacgatcgcatcggccggctcgcggtgcgcttagatgtgtct
cgactcgttgtcgtgggaaccgggaggtcgatcagcgccatgcaccacggagcggtcctg
gaggaggcgtggggctcgggggaagccactgctgatcacggtgcggatcgcacggccgtc
aatgtggccgacggtgacgccgccctggcactactgcgcgccgagctgcgacccggggat
gtggtcttggtcaaggcctcgaacgcggccgggctgggtgcggtggccgatgcattggtc
gcagacgacacatgcgggagtgtgcgcccatga

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