KEGG   Mycobacterium tuberculosis HKBS1: HKBS1_2247
Entry
HKBS1_2247        CDS       T03154                                 
Symbol
metH
Name
(GenBank) 5-methyltetrahydrofolate-homocysteine methyltransferase
  KO
K00548  5-methyltetrahydrofolate--homocysteine methyltransferase [EC:2.1.1.13]
Organism
mtq  Mycobacterium tuberculosis HKBS1
Pathway
mtq00270  Cysteine and methionine metabolism
mtq00450  Selenocompound metabolism
mtq00670  One carbon pool by folate
mtq01100  Metabolic pathways
mtq01110  Biosynthesis of secondary metabolites
mtq01230  Biosynthesis of amino acids
mtq04980  Cobalamin transport and metabolism
Module
mtq_M00017  Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:mtq00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    HKBS1_2247 (metH)
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    HKBS1_2247 (metH)
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    HKBS1_2247 (metH)
 09150 Organismal Systems
  09154 Digestive system
   04980 Cobalamin transport and metabolism
    HKBS1_2247 (metH)
Enzymes [BR:mtq01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.13  methionine synthase
     HKBS1_2247 (metH)
SSDB
Motif
Pfam: S-methyl_trans Pterin_bind Met_synt_B12 B12-binding_2 B12-binding Na_Ca_ex_C HTH_39
Other DBs
NCBI-ProteinID: AHJ42893
Position
complement(2378620..2382198)
AA seq 1192 aa
MTAADKHLYDTDLLDVLSQRVMVGDGAMGTQLQAADLTLDDFRGLEGCNEILNETRPDVL
ETIHRNYFEAGADAVETNTFGCNLSNLGDYDIADRIRDLSQKGTAIARRVADELGSPDRK
RYVLGSMGPGTKLPTLGHTEYAVIRDAYTEAALGMLDGGADAILVETCQDLLQLKAAVLG
SRRAMTRAGRHIPVFAHVTVETTGTMLLGSEIGAALTAVEPLGVDMIGLNCATGPAEMSE
HLRHLSRHARIPVSVMPNAGLPVLGAKGAEYPLLPDELAEALAGFIAEFGLSLVGGCCGT
TPAHIREVAAAVANIKRPERQVSYEPSVSSLYTAIPFAQDASVLVIGERTNANGSKGFRE
AMIAEDYQKCLDIAKDQTRDGAHLLDLCVDYVGRDGVADMKALASRLATSSTLPIMLDST
ETAVLQAGLEHLGGRCAINSVNYEDGDGPESRFAKTMALVAEHGAAVVALTIDEEGQART
AQKKVEIAERLINDITGNWGVDESSILIDTLTFTIATGQEESRRDGIETIEAIRELKKRH
PDVQTTLGLSNISFGLNPAARQVLNSVFLHECQEAGLDSAIVHASKILPMNRIPEEQRNV
ALDLVYDRRREDYDPLQELMRLFEGVSAASSKEDRLAELAGLPLFERLAQRIVDGERNGL
DADLDEAMTQKPPLQIINEHLLAGMKTVGELFGSGQMQLPFVLQSAEVMKAAVAYLEPHM
ERSDDDSGKGRIVLATVKGDVHDIGKNLVDIILSNNGYEVVNIGIKQPIATILEVAEDKS
ADVVGMSGLLVKSTVVMKENLEEMNTRGVAEKFPVLLGGAALTRSYVENDLAEIYQGEVH
YARDAFEGLKLMDTIMSAKRGEAPDENSPEAIKAREKEAERKARHQRSKRIAAQRKAAEE
PVEVPERSDVAADIEVPAPPFWGSRIVKGLAVADYTGLLDERALFLGQWGLRGQRGGEGP
SYEDLVETEGRPRLRYWLDRLSTDGILAHAAVVYGYFPAVSEGNDIVVLTEPKPDAPVRY
RFHFPRQQRGRFLCIADFIRSRELAAERGEVDVLPFQLVTMGQPIADFANELFASNAYRD
YLEVHGIGVQLTEALAEYWHRRIREELKFSGDRAMAAEDPEAKEDYFKLGYRGARFAFGY
GACPDLEDRAKMMALLEPERIGVTLSEELQLHPEQSTDAFVLHHPEAKYFNV
NT seq 3579 nt   +upstreamnt  +downstreamnt
gtgactgcggccgacaagcacctctacgacaccgatctgctcgacgtcttgtcgcagcga
gtgatggtcggcgacggtgcaatgggaacccaactacaggccgcggacctcacgctcgac
gacttccgcggcctggagggctgcaacgagatcctcaacgaaacccgccctgacgtgctg
gaaaccattcaccgcaactatttcgaagcgggcgccgacgccgtcgagacgaacacgttt
ggctgcaacctgtccaacctcggcgactacgacatcgccgacaggatccgcgatctatca
cagaagggcaccgcgatcgcacgccgggtggccgacgagctgggcagtcccgaccgcaag
cgctacgtgctggggtcgatggggccgggcaccaagctgccgactctgggccacaccgaa
tacgcggtgatccgcgacgcctacaccgaggccgcgctgggcatgctggacggcggagcc
gacgccatcctggtggaaacctgccaggacctactgcagctgaaggcggcggtgttgggg
tcgcggcgggcgatgacgcgggccgggcggcacattccggtgtttgcccacgtcaccgtc
gagaccaccggcaccatgctgctgggcagcgagatcggggcggcgttgaccgctgtcgag
ccgctcggtgtggacatgatcggcttgaactgcgcgacgggtccggccgagatgagcgag
cacctgcgccacctgtcccggcacgcccgcatcccggtgtcggtgatgcccaacgccggg
ttgccggtgctgggcgccaagggcgccgaatatccgttgctgcccgacgaattggccgag
gcgctggccggcttcatcgccgagttcgggctctcgctggtcggtggctgctgcggcacc
accccggcccatatccgcgaagtggctgccgcggttgcgaacatcaagcgtcccgagcga
caggtcagctacgagccgtcggtgtcgtcgctgtacaccgcaatcccgttcgcccaggac
gcctcggttctggtgatcggggagcgaacgaacgccaacggctccaagggttttcgtgag
gcgatgatcgccgaggactaccagaagtgcctggacatcgccaaggaccagacccgcgac
ggcgcccacctgctggacctgtgtgtggactacgtgggccgcgacggtgtggccgacatg
aaggcgctggccagccggctggccacgtcctcgacgctgccgatcatgctggactccacc
gaaaccgcggtgctgcaggcgggtttggagcatctgggtggccgttgcgcgatcaactcg
gtgaactacgaggacggcgacggcccggaatcgcgctttgccaagaccatggcgctggtc
gccgagcacggcgcggcggtggtcgcgctgaccatcgacgaagagggccaggcccgcacc
gcgcagaagaaggtcgagatcgccgagcggctgatcaacgacatcaccggcaactggggc
gtcgacgaatcatccatcctcatcgacaccttgacgttcaccatcgccaccggtcaggag
gagtcccgccgcgacggcatcgagaccatcgaggcgatccgcgaactgaaaaagcgccac
ccggatgtgcagaccacacttggtctgtccaacatctcgtttggtctcaatcccgcagcg
cgccaggtgctcaactcggtgttcctgcacgaatgccaagaagcggggctggattcggcg
atcgtgcacgcgtcgaagatcctgccgatgaaccggattcccgaggagcaacgcaacgtc
gccctggatctggtctacgaccgccgccgcgaggactacgatccgctgcaggagctgatg
cggctgttcgaaggcgtgtcggcggcctcctcgaaagaggaccgactggctgaactagct
gggctgccgctgttcgaacggctggcccaacgcatcgtcgacggcgagcgcaacggcctg
gacgccgatctcgacgaggcgatgacgcaaaagccgccgcttcagatcatcaacgaacat
ctgctggccggcatgaagacggtcggcgagctcttcggctccggccagatgcagctgccg
ttcgtgctgcagtcggcggaggtaatgaaagccgccgtcgcgtatctggaaccgcacatg
gagcgctcggacgacgattcgggcaagggacgcatcgtgctggccaccgtcaagggcgac
gtgcacgacatcggcaagaacctggtcgacatcatcttgagcaacaacggctacgaagtg
gtcaacatcggcatcaagcagccaatcgccaccatcctcgaagtcgccgaggacaagagc
gccgacgtggtcggcatgtcgggcctgctggtgaagtcgaccgtggtgatgaaggaaaac
ctcgaggagatgaacacccggggagtcgccgaaaagttcccggtgctgctcggcggcgcg
gcgttgacgcgcagctatgtcgaaaacgacctggccgagatctaccagggcgaagtgcat
tacgcgcgagacgctttcgagggcctgaagttgatggacaccatcatgagcgccaagcgc
ggcgaggcgcccgacgaaaacagcccggaagccattaaggcgcgtgagaaagaagccgaa
cgtaaggcccgccaccagcgatccaaacgcattgccgcacagcgcaaagccgccgaagaa
ccagtcgaggtgcccgaacgctccgatgtcgcggccgacatcgaggtcccggcgccgccg
ttctggggttcgcggatcgtcaagggcctggcggtggccgactacaccggtctgctcgat
gagcgcgcattgtttttgggccagtggggtttacgcggccagcgcggcggtgagggtccg
tcctacgaagatctcgtcgagaccgagggccggccgcggctgcggtactggttggaccgg
ctgtccaccgacggcatcttggcgcacgccgccgtggtgtacggctatttcccggcggtg
tccgagggcaacgacatcgtggtgctcaccgagcccaagcccgacgccccggtgcgctac
cggtttcacttcccgcgccagcagcgcggtcggtttttgtgcattgccgatttcatccgc
tcgcgggagctggccgccgagcgtggcgaggttgacgtgctgccgttccagctggtgacc
atgggtcagccgatcgcggatttcgccaacgagctgttcgcgtccaacgcctaccgcgac
tacctggaggtgcacggtatcggcgtgcagctcaccgaggcgctggccgagtactggcac
cggcggatccgtgaggagctcaagttctccggggatcgggcgatggcggccgaggatccg
gaggcgaaagaagactatttcaagctcggctaccgcggtgctcgctttgccttcggctac
ggcgcatgcccggatctggaggaccgcgccaagatgatggcgctgctggagcccgaacgc
atcggtgtgacgttatccgaggaattacagctgcatcccgaacagtcgaccgacgcgttc
gtcctgcaccatccggaagccaagtacttcaacgtttaa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (8)   
   KEGG PATHWAY (7)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   OC (1)   
Protein domain (7)   
   Pfam (7)   
All databases (32)   

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