KEGG   Mycobacterium tuberculosis H37Rv: Rv3710Help
Entry
Rv3710            CDS       T00015                                 

Gene name
leuA
Definition
(RefSeq) 2-isopropylmalate synthase
  KO
K01649  2-isopropylmalate synthase [EC:2.3.3.13]
Organism
mtu  Mycobacterium tuberculosis H37Rv
Pathway
mtu00290  Valine, leucine and isoleucine biosynthesis
mtu00620  Pyruvate metabolism
mtu01100  Metabolic pathways
mtu01110  Biosynthesis of secondary metabolites
mtu01210  2-Oxocarboxylic acid metabolism
mtu01230  Biosynthesis of amino acids
Module
mtu_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:mtu00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    Rv3710 (leuA)
  09105 Amino acid metabolism
   00290 Valine, leucine and isoleucine biosynthesis
    Rv3710 (leuA)
Enzymes [BR:mtu01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.13  2-isopropylmalate synthase
     Rv3710 (leuA)
BRITE hierarchy
SSDB OrthologParalogGene clusterGFIT
Motif
Pfam: HMGL-like LeuA_dimer
Motif
Other DBs
NCBI-GeneID: 885092
NCBI-ProteinID: NP_218227
TubercuList: Rv3710
UniProt: P9WQB3 I6X854
Structure
PDB: 

Position
4153740..4155674
Genome map
AA seq 644 aa AA seqDB search
MTTSESPDAYTESFGAHTIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRN
RTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQT
DFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVV
FRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIA
PTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELG
FAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPV
HERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGR
TYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEM
WDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVH
ALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPA
QPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR
NT seq 1935 nt NT seq  +upstreamnt  +downstreamnt
gtgacaacttctgaatcgcccgacgcctataccgagtcgtttggggcccacaccatcgtg
aaacccgccggcccacctcgcgtcggtcagccctcgtggaatccgcagcgagcctcgtcg
atgccggtcaaccgctaccggccgttcgccgaggaggtcgagcccatccggctgagaaac
cgcacgtggcctgatcgcgtcatcgatcgtgcgccgctgtggtgcgcggtcgacttacgc
gatggcaaccaggcgctgatcgacccgatgagcccggcccgcaagcgccgcatgttcgac
ctgctggtccggatgggctacaaggagattgaggtggggttcccctcggccagccagacc
gacttcgacttcgtcagagagatcatcgagcagggcgccattcccgacgacgtcaccatc
caggtgctcacccaatgccgtcccgagctgatcgagcgcaccttccaggcgtgttcgggc
gcaccccgggccatcgtgcacttctacaactcgacgtcaatcctgcagcgccgcgtggtc
tttcgcgccaaccgggctgaggtgcaggccatcgcgacagatggggcgcgcaagtgcgtc
gagcaggccgccaaatacccgggcacgcagtggcgattcgagtactccccggagtcctac
accggcaccgaactggaatacgccaaacaggtgtgcgacgccgtcggcgaggtcattgcg
ccgacgccggagcgcccgatcatcttcaacctgcccgccacggtggagatgacgacgccc
aatgtctacgccgactcgatcgagtggatgagccgcaacctagccaaccgggagtcggtc
atcctgagcctgcacccgcacaatgaccgcggaaccgccgtcgccgcagcggaattgggt
ttcgcggccggggctgatcggatcgagggctgcctgttcggcaacggcgagcgcaccggc
aacgtgtgcctggtcacgctgggactcaacctgttctcccgaggtgtggacccgcagatc
gacttctccaatattgacgagatccggcgcacggtggagtactgcaaccagctgccggtg
cacgaacgtcacccctatggcggcgacctggtgtacaccgcgttctccggtagccaccag
gacgccatcaacaagggcctagacgcgatgaagctggatgcggatgccgccgactgtgac
gtcgacgacatgctgtggcaggtgccgtatctgcccatcgacccgcgcgatgtcgggcgc
acctacgaggcggtgatccgggtcaactcgcagtccggcaagggcggcgtggcctacatc
atgaagaccgaccacggcctttccctgccgcggcggctgcagatcgagttttcccaggta
atccagaagatcgcagagggtacagcaggcgagggtggcgaggtctcgcccaaggagatg
tgggatgcgttcgccgaggagtatctggccccggtgcggcctttggagcggataaggcaa
catgtggacgctgccgacgacgacggcggcacgaccagcatcacggcgaccgtcaagatc
aacggcgtggagaccgagatcagcgggtccggtaacggtccgttggccgcgttcgtccat
gcgctggccgatgtcgggtttgacgtggccgtgctggactactacgagcacgcgatgagc
gccggcgacgacgctcaggccgccgcgtatgtggaggcctccgtgacgatcgcgagcccg
gcgcagccgggcgaagcgggtcggcacgcatcggaccccgtgacgatcgcgagcccggcg
cagccgggcgaagcgggtcggcacgcatcggaccccgtgacgagtaagacggtgtggggt
gtcggtatcgcaccgtcaatcaccaccgcgtcgctgcgcgccgtggtgtcggcggtcaac
cgggcggcacgctag

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