KEGG   Mycobacterium tuberculosis H37Rv: Rv0509
Entry
Rv0509            CDS       T00015                                 
Symbol
hemA
Name
(RefSeq) glutamyl-tRNA reductase
  KO
K02492  glutamyl-tRNA reductase [EC:1.2.1.70]
Organism
mtu  Mycobacterium tuberculosis H37Rv
Pathway
mtu00860  Porphyrin metabolism
mtu01100  Metabolic pathways
mtu01110  Biosynthesis of secondary metabolites
mtu01120  Microbial metabolism in diverse environments
mtu01240  Biosynthesis of cofactors
Module
mtu_M00846  Siroheme biosynthesis, glutamyl-tRNA => siroheme
mtu_M00926  Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:mtu00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00860 Porphyrin metabolism
    Rv0509 (hemA)
Enzymes [BR:mtu01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.70  glutamyl-tRNA reductase
     Rv0509 (hemA)
SSDB
Motif
Pfam: GlutR_N Shikimate_DH GlutR_dimer Glu_dehyd_C Sacchrp_dh_NADP NAD_binding_2 ThiF ApbA F420_oxidored NAD_binding_7 2-Hacid_dh_C NAD_binding_10
Other DBs
NCBI-GeneID: 887292
NCBI-ProteinID: NP_215023
TubercuList: Rv0509
UniProt: P9WMP7
Position
600441..601847
AA seq 468 aa
MSVLLFGVSHRSAPVVVLEQLSIDESDQVKIIDRVLASPLVTEAMVLSTCNRVEVYAVVD
AFHGGLSVIGQVLAEHSGMSMGELTKYAYVRYSEAAVEHLFAVASGLDSAVIGEQQVLGQ
VRRAYAVAESNRTVGRVLHELAQRALSVGKRVHSETAIDAAGASVVSVALGMAERKLGSL
AGTTAVVIGAGAMGALSAVHLTRAGVGHIQVLNRSLSRAQRLARRIRESGVPAEALALDR
LANVLADADVVVSCTGAVRPVVSLADVHHALAAARRDEATRPLVICDLGMPRDVDPAVAR
LPCVWVVDVDSVQHEPSAHAAAADVEAARHIVAAEVASYLVGQRMAEVTPTVTALRQRAA
EVVEAELLRLDNRLPGLQSVQREEVARTVRRVVDKLLHAPTVRIKQLASAPGGDSYAEAL
RELFELDQTAVDAVATAGELPVVPSGFDAESRRGGGDMQSSPKRSPSN
NT seq 1407 nt   +upstreamnt  +downstreamnt
gtgagcgtgctgctcttcggggtgtcgcatcgtagcgcgccggtcgtcgtccttgaacaa
ctcagtatcgacgaatccgatcaagtcaagatcatcgaccgagtgctggcttcgccgctg
gtgaccgaggcgatggtgctgtcgacttgcaaccgcgtcgaggtctacgccgtagtggac
gcgttccatggcggcctgtcggtgatcgggcaggtgcttgccgaacactccggtatgtcg
atgggggagctgaccaagtacgcatatgtccgctacagcgaggcagcagttgagcacctg
ttcgcggttgccagcggcctggactcggcggtgatcggcgagcagcaggtgcttggtcag
gtgcgccgcgcctatgccgtcgccgaatccaaccgcacggtcggccgcgtgctgcacgaa
ttggcccagcgggcgctgtcggtgggcaagcgagtgcactccgaaaccgccattgacgct
gccggtgcctccgtggtgtcggtcgccctgggaatggccgagcgcaaattgggctcgttg
gcgggcacgaccgcggtggtgatcggcgccggggcgatgggcgcgctgtcggcggtacat
ctgacccgtgccggcgtcgggcacattcaggtgctcaaccggtcgttgtcccgggcgcag
cggttggcccgaaggatccgcgaatctggcgtgccggccgaggcgctagcgctcgaccgc
ctggctaatgtcctggccgatgccgacgtggtggtcagctgtactggggcggtgcgtccg
gtggtgtcgctggccgatgtgcatcatgcgctggccgccgcccgccgtgacgaggccacc
cgtccgttggtgatatgcgacttgggcatgccgcgtgacgtcgatcctgcggtggccaga
ttaccgtgtgtgtgggtcgtggacgtggatagcgtgcaacatgaaccctcggcacatgcc
gcggctgccgacgttgaggccgcccgccacatcgtcgccgccgaagttgccagctatctg
gtggggcagcggatggccgaggtcaccccaaccgtgacggcgttgcgccagcgagccgcc
gaagtggtcgaagcggaattgctgcgcctggacaaccggctgcccggcctgcagagtgtc
cagcgcgaggaggtggcccgcaccgtacggcgagtcgtggacaagctgttgcacgcgcct
accgtgcggatcaagcagctcgccagtgcgcccggcggtgacagctacgccgaggcgctg
cgcgaactcttcgagcttgaccagaccgccgtcgatgccgtcgccactgcaggtgaatta
ccggtggtgccaagcggattcgacgctgaaagtcgccgcggtggaggcgacatgcaaagc
agcccgaagcgatcgccgagtaactga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (8)   
   KEGG PATHWAY (5)   
   KEGG MODULE (3)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
   TUBERCULIST (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
Protein domain (12)   
   Pfam (12)   
All databases (45)   

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