KEGG T05884: 110563735

Meriones unguiculatus (Mongolian gerbil): 110563735

Entry

110563735         CDS       T05884

Name

(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1-like

K00070

3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]

Organism

mun Meriones unguiculatus (Mongolian gerbil)

Pathway

mun00140

Steroid hormone biosynthesis

mun01100

Metabolic pathways

mun04913

Ovarian steroidogenesis

mun04925

Aldosterone synthesis and secretion

mun04927

Cortisol synthesis and secretion

mun04934

Cushing syndrome

Module

mun_M00107

Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone

mun_M00110

C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone

mun_M00976

C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone

Brite

KEGG Orthology (KO) [BR:mun00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    110563735
09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    110563735
   04925 Aldosterone synthesis and secretion
    110563735
   04927 Cortisol synthesis and secretion
    110563735
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    110563735
Enzymes [BR:mun01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     110563735
5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     110563735

SSDB

Motif

Pfam:

3Beta_HSD Epimerase NAD_binding_4 GDP_Man_Dehyd Polysacc_synt_2 NAD_binding_10 NmrA RmlD_sub_bind KR Ldh_1_N Ufm1 Sacchrp_dh_NADP

Other DBs

NCBI-GeneID:

110563735

NCBI-ProteinID:

XP_021516588

Position

10:106212774..106230983

AA seq 419 aa
MNSADLCYAWCLPLRWTSGILMTEFALSRVTWHHTRSYYNLLPALTMPGWSCLVTGAGGF
LGQKIIQMLVQEKDLQEIRALDKVFRPETKEEFSRLQTKTKVTVLEGDILDAQCLRRACQ
GISVVIHTAAVIDVQGVIPRQTILDVNLKGTQKLLEACVQANVSSFILTSTVDVAGPNSY
KQIILDGHEEDNLESTWSDPYPYSKKMAEKAVLAANGCTLRNGGTLHTCALRPMCIYGEK
SSIFYNIIIGALKNKGVLDTTGKFSRVNPVYVGNAAWAHILAARGLRDPKKSPSIQGQFY
YISDDTPHQSYDDLNYTLSKEWGLRPDSSWSLPLPLLYWLAFLLETVSFLLRPVYNYRPP
FTCHLVTLSNSTFAFSYKKAQHDLGYEPCVTWEEAKQKTSEWIGTLVEQHKETMNSKTR

NT seq 1260 nt +upstreamnt +downstreamnt
atgaacagtgctgatttgtgttacgcttggtgtttgcctttgaggtggacttctgggatc
ctgatgactgagtttgccctttccagggtcacttggcaccacacccggtcctactataat
ctgcttccagcattgaccatgccagggtggagctgcctggtgacaggagcaggagggttt
ctgggccagaagatcatccaaatgttggtgcaggagaaagacctgcaggagatcagggct
ctggacaaggtcttcagaccagaaaccaaggaggaattctctaggctgcagacaaaaacc
aaggtgacagtgcttgagggagacattctggatgcccagtgcctgagaagagcctgccag
ggcatctctgttgtcatccacactgctgctgtcattgatgtccaaggggtcattcccaga
cagaccatcctagatgtcaatctgaaaggtacccagaagctgttggaggcgtgtgtccaa
gctaatgtgtcatccttcatcttaaccagcacagttgatgtggcagggcccaactcctac
aagcagatcatcttggatggccatgaagaagacaatctagaaagtacatggtctgatcca
tatccatacagcaaaaagatggctgagaaggcagtgctggcagccaatgggtgcaccctg
agaaatggtggcactttacatacttgtgccttaaggcccatgtgcatttatggggaaaaa
agctcaatcttttataacataataattggagctctgaaaaataagggtgttctggatact
acaggcaaattctctagagtcaacccagtatatgtaggaaacgcagcctgggcacacatt
ctggctgccaggggcctacgcgaccccaagaagtcacccagcatccaaggtcagttctac
tacatttcagatgacacccctcaccaaagctatgatgacttaaattacaccctgagcaag
gaatggggcctccgccctgattccagttggagccttcctctgcccctgctctactggctt
gccttcctgctggaaactgtgagcttcctgctgcgtccagtctacaactaccggcccccc
tttacctgccacttggttacgctgtccaacagcacgtttgccttctcctacaagaaagcc
cagcacgatctcggctatgagccgtgtgtcacctgggaggaagccaagcagaaaacctca
gagtggatcgggacactagtggagcaacacaaggagacaatgaactcaaagactcggtga

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