KEGG   NETWORK: N00016Help
Entry
N00016                      Network                                

Name
PDGF-overexpression to RAS-ERK signaling pathway
Definition
PDGF* -> PDGFR -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
  Expanded
(5154v1,5155v1) -> (5156,5159) -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06210 ERK signaling
nt06273 Glioma
Type
Variant
Pathway
hsa05214  Glioma
Disease
H00042  Glioma
Gene
5154  PDGFA; platelet derived growth factor subunit A
5155  PDGFB; platelet derived growth factor subunit B
5156  PDGFRA; platelet derived growth factor receptor alpha
5159  PDGFRB; platelet derived growth factor receptor beta
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Variant
5154v1  PDGFA overexpression
5155v1  PDGFB overexpression
Reference
  Authors
Westermark B
  Title
Platelet-derived growth factor in glioblastoma-driver or biomarker?
  Journal
Ups J Med Sci 119:298-305 (2014)
DOI:10.3109/03009734.2014.970304
Reference
  Authors
Zhu Y, Parada LF.
  Title
The molecular and genetic basis of neurological tumours.
  Journal
Nat Rev Cancer 2:616-26 (2002)
DOI:10.1038/nrc866
Reference
  Authors
Holland EC.
  Title
Gliomagenesis: genetic alterations and mouse models.
  Journal
Nat Rev Genet 2:120-9 (2001)
DOI:10.1038/35052535

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