KEGG   NETWORK: N00017Help
Entry
N00017                      Network                                

Name
Mutation-activated SMO to Hedgehog signaling pathway
Definition
SMO* -> SUFU // GLI => (BMP2/4,HHIP,GLI1,PTCH,WNT)
  Expanded
6608v1 -> 51684 // (2735,2736,2737) => (650,652,64399,2735,5727,8643,7471,7472,7482,7473,89780,54361,7474,81029,7475,7476,7477,7478,7479,7483,7484,80326,7480,51384)
Class
nt06217 HH signaling
nt06269 Basal cell carcinoma
Type
Variant
Pathway
hsa05217  Basal cell carcinoma
Disease
H00039  Basal cell carcinoma
Gene
6608  SMO; smoothened, frizzled class receptor
51684  SUFU; SUFU negative regulator of hedgehog signaling
2735  GLI1; GLI family zinc finger 1
2736  GLI2; GLI family zinc finger 2
2737  GLI3; GLI family zinc finger 3
650  BMP2; bone morphogenetic protein 2
652  BMP4; bone morphogenetic protein 4
64399  HHIP; hedgehog interacting protein
5727  PTCH1; patched 1
8643  PTCH2; patched 2
7471  WNT1; Wnt family member 1
7472  WNT2; Wnt family member 2
7482  WNT2B; Wnt family member 2B
7473  WNT3; Wnt family member 3
89780  WNT3A; Wnt family member 3A
54361  WNT4; Wnt family member 4
7474  WNT5A; Wnt family member 5A
81029  WNT5B; Wnt family member 5B
7475  WNT6; Wnt family member 6
7476  WNT7A; Wnt family member 7A
7477  WNT7B; Wnt family member 7B
7478  WNT8A; Wnt family member 8A
7479  WNT8B; Wnt family member 8B
7483  WNT9A; Wnt family member 9A
7484  WNT9B; Wnt family member 9B
80326  WNT10A; Wnt family member 10A
7480  WNT10B; Wnt family member 10B
51384  WNT16; Wnt family member 16
Variant
6608v1  SMO mutation
Reference
  Authors
Pasca di Magliano M, Hebrok M.
  Title
Hedgehog signalling in cancer formation and maintenance.
  Journal
Nat Rev Cancer 3:903-11 (2003)
DOI:10.1038/nrc1229
Reference
  Authors
Saldanha G, Fletcher A, Slater DN.
  Title
Basal cell carcinoma: a dermatopathological and molecular biological update.
  Journal
Br J Dermatol 148:195-202 (2003)
DOI:10.1046/j.1365-2133.2003.05151.x
Reference
  Authors
Tsai KY, Tsao H.
  Title
The genetics of skin cancer.
  Journal
Am J Med Genet C Semin Med Genet 131C:82-92 (2004)
DOI:10.1002/ajmg.c.30037
Reference
  Authors
Iwasaki JK, Srivastava D, Moy RL, Lin HJ, Kouba DJ
  Title
The molecular genetics underlying basal cell carcinoma pathogenesis and links to targeted therapeutics.
  Journal
J Am Acad Dermatol 66:e167-78 (2012)
DOI:10.1016/j.jaad.2010.06.054

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