KEGG   NETWORK: N00024Help
Entry
N00024                      Network                                

Name
Mutation-activated EGFR to PLCG-ERK signaling pathway
Definition
EGFR* -> PLCG -> (Ca2+,DAG) -> PKC -> RAF -> MEK -> ERK -> CCND1
  Expanded
(1956v2,1956v3) -> (5335,5336) -> (C00076,C00165) -> (5578,5579,5582) -> (369,673,5894) -> (5604,5605) -> (5594,5595) -> 595
Class
nt06210 ERK signaling
nt06266 Non-small cell lung cancer
Type
Variant
Pathway
hsa05223  Non-small cell lung cancer
Disease
H00014  Non-small cell lung cancer
Gene
1956  EGFR; epidermal growth factor receptor
5335  PLCG1; phospholipase C gamma 1
5336  PLCG2; phospholipase C gamma 2
5578  PRKCA; protein kinase C alpha
5579  PRKCB; protein kinase C beta
5582  PRKCG; protein kinase C gamma
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
595  CCND1; cyclin D1
Variant
1956v2  EGFR mutation in non-small cell lung cancer
1956v3  First generation TKI-resistant EGFR mutation
Reference
  Authors
Osada H, Takahashi T.
  Title
Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer.
  Journal
Oncogene 21:7421-34 (2002)
DOI:10.1038/sj.onc.1205802

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