KEGG   NETWORK: N00026
Entry
N00026                      Network                                

Name
EGF-EGFR-PLCG-CAMK signaling pathway
Definition
EGF -> EGFR -> PLCG -> IP3 -> Ca2+ -> CALM -- CAMK
  Expanded
1950 -> 1956 -> (5335,5336) -> C01245 -> C00076 -> (801,805,808) -- (8536,57118,57172,815,816,817,818,814)
Class
nt06220 Calcium signaling
nt06273 Glioma
Type
Reference
Pathway
hsa04020  Calcium signaling pathway
Gene
1950  EGF; epidermal growth factor
1956  EGFR; epidermal growth factor receptor
5335  PLCG1; phospholipase C gamma 1
5336  PLCG2; phospholipase C gamma 2
801  CALM1; calmodulin 1
805  CALM2; calmodulin 2
808  CALM3; calmodulin 3
8536  CAMK1; calcium/calmodulin dependent protein kinase I
57118  CAMK1D; calcium/calmodulin dependent protein kinase ID
57172  CAMK1G; calcium/calmodulin dependent protein kinase IG
815  CAMK2A; calcium/calmodulin dependent protein kinase II alpha
816  CAMK2B; calcium/calmodulin dependent protein kinase II beta
817  CAMK2D; calcium/calmodulin dependent protein kinase II delta
818  CAMK2G; calcium/calmodulin dependent protein kinase II gamma
814  CAMK4; calcium/calmodulin dependent protein kinase IV
Metabolite
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
Reference
  Authors
Roderick HL, Cook SJ
  Title
Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival.
  Journal
Nat Rev Cancer 8:361-75 (2008)
DOI:10.1038/nrc2374

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