KEGG   NETWORK: N00029
Entry
N00029                      Network                                

Name
Amplified PDGFR to PLCG-CAMK signaling pathway
Definition
PDGFR* -> PLCG -> IP3 -> Ca2+ -> CALM -- CAMK
  Expanded
5156v1 -> (5335,5336) -> C01245 -> C00076 -> (801,805,808) -- (8536,57118,57172,815,816,817,818,814)
Class
nt06220 Calcium signaling
nt06273 Glioma
Type
Variant
Pathway
hsa05214  Glioma
Disease
H00042  Glioma
Gene
5156  PDGFRA; platelet derived growth factor receptor alpha
5335  PLCG1; phospholipase C gamma 1
5336  PLCG2; phospholipase C gamma 2
801  CALM1; calmodulin 1
805  CALM2; calmodulin 2
808  CALM3; calmodulin 3
8536  CAMK1; calcium/calmodulin dependent protein kinase I
57118  CAMK1D; calcium/calmodulin dependent protein kinase ID
57172  CAMK1G; calcium/calmodulin dependent protein kinase IG
815  CAMK2A; calcium/calmodulin dependent protein kinase II alpha
816  CAMK2B; calcium/calmodulin dependent protein kinase II beta
817  CAMK2D; calcium/calmodulin dependent protein kinase II delta
818  CAMK2G; calcium/calmodulin dependent protein kinase II gamma
814  CAMK4; calcium/calmodulin dependent protein kinase IV
Variant
5156v1 (PDGFR*)  PDGFRA amplification
Metabolite
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
Reference
  Authors
Kapoor GS, O'Rourke DM.
  Title
Mitogenic signaling cascades in glial tumors.
  Journal
Neurosurgery 52:1425-34; discussion 1434-5 (2003)
DOI:10.1227/01.NEU.0000065135.28143.39
Reference
  Authors
Khoshyomn S, Penar PL, Rossi J, Wells A, Abramson DL, Bhushan A
  Title
Inhibition of phospholipase C-gamma1 activation blocks glioma cell motility and invasion of fetal rat brain aggregates.
  Journal
Neurosurgery 44:568-77 (1999)
DOI:10.1097/00006123-199903000-00073
Reference
  Authors
Westermark B
  Title
Platelet-derived growth factor in glioblastoma-driver or biomarker?
  Journal
Ups J Med Sci 119:298-305 (2014)
DOI:10.3109/03009734.2014.970304

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