KEGG   NETWORK: N00032Help
Entry
N00032                      Network                                

Name
Mutation-activated KRAS/NRAS to PI3K signaling pathway
Definition
(KRAS*,NRAS*) -> PI3K -> PIP3 -> AKT -| BAD
  Expanded
(3845v1,4893v1) -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572
Class
nt06214 PI3K signaling
nt06260 Colorectal cancer
nt06262 Pancreatic cancer
nt06266 Non-small cell lung cancer
nt06268 Melanoma
nt06275 Acute myeloid leukemia
Type
Variant
Pathway
hsa05210  Colorectal cancer
hsa05212  Pancreatic cancer
hsa05221  Acute myeloid leukemia
hsa05223  Non-small cell lung cancer
hsa05218  Melanoma
Disease
H00020  Colorectal cancer
H00019  Pancreatic cancer
H00003  Acute myeloid leukemia
H00014  Non-small cell lung cancer
H00038  Melanoma
Gene
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
572  BAD; BCL2 associated agonist of cell death
Variant
3845v1  KRAS mutation
4893v1  NRAS mutation
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Schubbert S, Shannon K, Bollag G
  Title
Hyperactive Ras in developmental disorders and cancer.
  Journal
Nat Rev Cancer 7:295-308 (2007)
DOI:10.1038/nrc2109
Reference
  Authors
Adjei AA.
  Title
Blocking oncogenic Ras signaling for cancer therapy.
  Journal
J Natl Cancer Inst 93:1062-74 (2001)
DOI:10.1093/jnci/93.14.1062
Reference
  Authors
Janssen KP.
  Title
Murine models of colorectal cancer: studying the role of oncogenic K-ras.
  Journal
Cell Mol Life Sci 60:495-506 (2003)
DOI:10.1007/s000180300041
Reference
  Authors
Martelli AM, Nyakern M, Tabellini G, Bortul R, Tazzari PL, Evangelisti C, Cocco L.
  Title
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia.
  Journal
Leukemia 20:911-28 (2006)
DOI:10.1038/sj.leu.2404245
Reference
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166

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