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Entry
N00037                      Network                                

Name
FGF-FGFR-PI3K signaling pathway
Definition
FGF -> FGFR -> PI3K -> PIP3 -> AKT -> MTOR -> S6K
  Expanded
(2246,2247,2248,2249,2250,2251,2252,2253,2254,2255,8823,8822,8817,9965,26281,26291,27006,8074) -> (2260,2263,2261,2264) -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475 -> (6198,6199)
Class
nt06214 PI3K signaling
nt06261 Gastric cancer
nt06270 Breast cancer
Type
Reference
Pathway
hsa04151  PI3K-Akt signaling pathway
Gene
2246  FGF1; fibroblast growth factor 1
2247  FGF2; fibroblast growth factor 2
2248  FGF3; fibroblast growth factor 3
2249  FGF4; fibroblast growth factor 4
2250  FGF5; fibroblast growth factor 5
2251  FGF6; fibroblast growth factor 6
2252  FGF7; fibroblast growth factor 7
2253  FGF8; fibroblast growth factor 8
2254  FGF9; fibroblast growth factor 9
2255  FGF10; fibroblast growth factor 10
8823  FGF16; fibroblast growth factor 16
8822  FGF17; fibroblast growth factor 17
8817  FGF18; fibroblast growth factor 18
9965  FGF19; fibroblast growth factor 19
26281  FGF20; fibroblast growth factor 20
26291  FGF21; fibroblast growth factor 21
27006  FGF22; fibroblast growth factor 22
8074  FGF23; fibroblast growth factor 23
2260  FGFR1; fibroblast growth factor receptor 1
2263  FGFR2; fibroblast growth factor receptor 2
2261  FGFR3; fibroblast growth factor receptor 3
2264  FGFR4; fibroblast growth factor receptor 4
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin
6198  RPS6KB1; ribosomal protein S6 kinase B1
6199  RPS6KB2; ribosomal protein S6 kinase B2
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Liu P, Cheng H, Roberts TM, Zhao JJ
  Title
Targeting the phosphoinositide 3-kinase pathway in cancer.
  Journal
Nat Rev Drug Discov 8:627-44 (2009)
DOI:10.1038/nrd2926
Reference
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8

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