KEGG   NETWORK: N00043Help
Entry
N00043                      Network                                

Name
HGF-MET-PI3K signaling pathway
Definition
HGF -> MET -> GAB1 -> PI3K -> PIP3 -> AKT -| BAD
  Expanded
3082 -> 4233 -> 2549 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -| 572
Class
nt06214 PI3K signaling
nt06261 Gastric cancer
nt06263 Hepatocellular carcinoma
nt06264 Renal cell carcinoma
Type
Reference
Pathway
hsa04151  PI3K-Akt signaling pathway
Gene
3082  HGF; hepatocyte growth factor
2549  GAB1; GRB2 associated binding protein 1
4233  MET; MET proto-oncogene, receptor tyrosine kinase
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF.
  Title
Met, metastasis, motility and more.
  Journal
Nat Rev Mol Cell Biol 4:915-25 (2003)
DOI:10.1038/nrm1261
Reference
  Authors
Bradley CA, Salto-Tellez M, Laurent-Puig P, Bardelli A, Rolfo C, Tabernero J, Khawaja HA, Lawler M, Johnston PG, Van Schaeybroeck S
  Title
Targeting c-MET in gastrointestinal tumours: rationale, opportunities and challenges.
  Journal
Nat Rev Clin Oncol 14:562-576 (2017)
DOI:10.1038/nrclinonc.2017.40
Reference
  Authors
Meyer R, D'Alessandro LA, Kar S, Kramer B, She B, Kaschek D, Hahn B, Wrangborg D, Karlsson J, Kvarnstrom M, Jirstrand M, Lehmann WD, Timmer J, Hofer T, Klingmuller U
  Title
Heterogeneous kinetics of AKT signaling in individual cells are accounted for by variable protein concentration.
  Journal
Front Physiol 3:451 (2012)
DOI:10.3389/fphys.2012.00451

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