KEGG   NETWORK: N00045Help
Entry
N00045                      Network                                

Name
KITLG-KIT-PI3K signaling pathway
Definition
KITLG -> KIT -> PI3K -> PIP3 -> AKT -> MTOR -> S6K
  Expanded
4254 -> 3815 -> (5290,5291,5293) -> C05981 -> (207,208,10000) -> 2475 -> (6198,6199)
Class
nt06214 PI3K signaling
nt06275 Acute myeloid leukemia
Type
Reference
Pathway
hsa04151  PI3K-Akt signaling pathway
Gene
4254  KITLG; KIT ligand
3815  KIT; KIT proto-oncogene receptor tyrosine kinase
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5291  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5293  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin
6198  RPS6KB1; ribosomal protein S6 kinase B1
6199  RPS6KB2; ribosomal protein S6 kinase B2
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Mithraprabhu S, Loveland KL
  Title
Control of KIT signalling in male germ cells: what can we learn from other systems?
  Journal
Reproduction 138:743-57 (2009)
DOI:10.1530/REP-08-0537
Reference
  Authors
Draber P, Halova I, Polakovicova I, Kawakami T
  Title
Signal transduction and chemotaxis in mast cells.
  Journal
Eur J Pharmacol 778:11-23 (2016)
DOI:10.1016/j.ejphar.2015.02.057

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