KEGG   NETWORK: N00049Help
Entry
N00049                      Network                                

Name
Mutation-activated PI3K to PI3K signaling pathway
Definition
PI3K* -> PIP3 -> AKT -> MTOR -> S6K
  Expanded
5290v1 -> C05981 -> (207,208,10000) -> 2475 -> (6198,6199)
Class
nt06214 PI3K signaling
nt06263 Hepatocellular carcinoma
nt06270 Breast cancer
Type
Variant
Pathway
hsa05225  Hepatocellular carcinoma
hsa05224  Breast cancer
Disease
H00048  Hepatocellular carcinoma
H00031  Breast cancer
Gene
5290  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
2475  MTOR; mechanistic target of rapamycin
6198  RPS6KB1; ribosomal protein S6 kinase B1
6199  RPS6KB2; ribosomal protein S6 kinase B2
Variant
5290v1  PIK3CA mutation
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Ignatiadis M, Sotiriou C
  Title
Luminal breast cancer: from biology to treatment.
  Journal
Nat Rev Clin Oncol 10:494-506 (2013)
DOI:10.1038/nrclinonc.2013.124
Reference
  Authors
Mukohara T
  Title
PI3K mutations in breast cancer: prognostic and therapeutic implications.
  Journal
Breast Cancer (Dove Med Press) 7:111-23 (2015)
DOI:10.2147/BCTT.S60696
Reference
  Authors
Whittaker S, Marais R, Zhu AX
  Title
The role of signaling pathways in the development and treatment of hepatocellular carcinoma.
  Journal
Oncogene 29:4989-5005 (2010)
DOI:10.1038/onc.2010.236

DBGET integrated database retrieval system