KEGG   NETWORK: N00051
Entry
N00051                      Network                                

Name
Deleted PTEN to PI3K signaling pathway
Definition
PTEN* // PIP3 -> AKT
  Expanded
5728v1 // C05981 -> (207,208,10000)
Class
nt06214 PI3K signaling
nt06267 Small cell lung cancer
nt06268 Melanoma
nt06273 Glioma
Type
Variant
Pathway
hsa05214  Glioma
hsa05218  Melanoma
hsa05222  Small cell lung cancer
Disease
H00042  Glioma
H00038  Melanoma
H00013  Small cell lung cancer
Gene
5728  PTEN; phosphatase and tensin homolog
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Variant
5728v1 (PTEN*)  PTEN deletion
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Chalhoub N, Baker SJ
  Title
PTEN and the PI3-kinase pathway in cancer.
  Journal
Annu Rev Pathol 4:127-50 (2009)
DOI:10.1146/annurev.pathol.4.110807.092311
Reference
  Authors
Soni D, King JA, Kaye AH, Hovens CM.
  Title
Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.
  Journal
J Clin Neurosci 12:1-5 (2005)
DOI:10.1016/j.jocn.2004.04.001
Reference
  Authors
Curtin JA, Fridlyand J, Kageshita T, Patel HN, Busam KJ, Kutzner H, Cho KH, Aiba S, Brocker EB, LeBoit PE, Pinkel D, Bastian BC
  Title
Distinct sets of genetic alterations in melanoma.
  Journal
N Engl J Med 353:2135-47 (2005)
DOI:10.1056/NEJMoa050092
Reference
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166

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