KEGG   NETWORK: N00052
Entry
N00052                      Network                                

Name
Mutation-inactivated PTEN to PI3K signaling pathway
Definition
PTEN* // PIP3 -> AKT
  Expanded
5728v2 // C05981 -> (207,208,10000)
Class
nt06214 PI3K signaling
nt06263 Hepatocellular carcinoma
nt06267 Small cell lung cancer
nt06268 Melanoma
nt06270 Breast cancer
nt06271 Endometrial cancer
nt06272 Prostate cancer
nt06273 Glioma
Type
Variant
Pathway
hsa05225  Hepatocellular carcinoma
hsa05214  Glioma
hsa05218  Melanoma
hsa05215  Prostate cancer
hsa05213  Endometrial cancer
hsa05224  Breast cancer
hsa05222  Small cell lung cancer
Disease
H00048  Hepatocellular carcinoma
H00042  Glioma
H00038  Melanoma
H00024  Prostate cancer
H00026  Endometrial cancer
H00031  Breast cancer
H00013  Small cell lung cancer
Gene
5728  PTEN; phosphatase and tensin homolog
207  AKT1; AKT serine/threonine kinase 1
208  AKT2; AKT serine/threonine kinase 2
10000  AKT3; AKT serine/threonine kinase 3
Variant
5728v2 (PTEN*)  PTEN mutation
Metabolite
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Chalhoub N, Baker SJ
  Title
PTEN and the PI3-kinase pathway in cancer.
  Journal
Annu Rev Pathol 4:127-50 (2009)
DOI:10.1146/annurev.pathol.4.110807.092311
Reference
  Authors
Zhu Y, Parada LF.
  Title
The molecular and genetic basis of neurological tumours.
  Journal
Nat Rev Cancer 2:616-26 (2002)
DOI:10.1038/nrc866
Reference
  Authors
Knobbe CB, Merlo A, Reifenberger G.
  Title
Pten signaling in gliomas.
  Journal
Neuro-oncol 4:196-211 (2002)
DOI:10.1093/neuonc/4.3.196
Reference
  Authors
Curtin JA, Fridlyand J, Kageshita T, Patel HN, Busam KJ, Kutzner H, Cho KH, Aiba S, Brocker EB, LeBoit PE, Pinkel D, Bastian BC
  Title
Distinct sets of genetic alterations in melanoma.
  Journal
N Engl J Med 353:2135-47 (2005)
DOI:10.1056/NEJMoa050092
Reference
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166
Reference
  Authors
Whittaker S, Marais R, Zhu AX
  Title
The role of signaling pathways in the development and treatment of hepatocellular carcinoma.
  Journal
Oncogene 29:4989-5005 (2010)
DOI:10.1038/onc.2010.236

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