KEGG   NETWORK: N00054Help
Entry
N00054                      Network                                

Name
Duplication or mutation-activated FLT3 to Jak-STAT signaling pathway
Definition
FLT3* -> STAT5 => PIM1/2
  Expanded
(2322v2,2322v1) -> (6776,6777) => (5292,11040)
Class
nt06219 JAK-STAT signaling
nt06275 Acute myeloid leukemia
Type
Variant
Pathway
hsa05221  Acute myeloid leukemia
Disease
H00003  Acute myeloid leukemia
Gene
2322  FLT3; fms related tyrosine kinase 3
6776  STAT5A; signal transducer and activator of transcription 5A
6777  STAT5B; signal transducer and activator of transcription 5B
5292  PIM1; Pim-1 proto-oncogene, serine/threonine kinase
11040  PIM2; Pim-2 proto-oncogene, serine/threonine kinase
Variant
2322v2  FLT3 internal tandem duplication (ITD)
2322v1  FLT3 kinase domain mutation
Reference
  Authors
Rocnik JL, Okabe R, Yu JC, Lee BH, Giese N, Schenkein DP, Gilliland DG
  Title
Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD.
  Journal
Blood 108:1339-45 (2006)
DOI:10.1182/blood-2005-11-011429
Reference
  Authors
Choudhary C, Muller-Tidow C, Berdel WE, Serve H.
  Title
Signal transduction of oncogenic Flt3.
  Journal
Int J Hematol 82:93-9 (2005)
DOI:10.1532/IJH97.05090
Reference
  Authors
Choudhary C, Brandts C, Schwable J, Tickenbrock L, Sargin B, Ueker A, Bohmer FD, Berdel WE, Muller-Tidow C, Serve H
  Title
Activation mechanisms of STAT5 by oncogenic Flt3-ITD.
  Journal
Blood 110:370-4 (2007)
DOI:10.1182/blood-2006-05-024018

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