KEGG   NETWORK: N00061Help
Entry
N00061                      Network                                

Name
CDH1-reduced expression to beta-catenin signaling pathway
Definition
CDH1* // CTNNB1 -> TCF/LEF => (MYC,CCND1)
  Expanded
999v1 // 1499 -> (6932,83439,6934,51176) => (4609,595)
Class
nt06215 WNT signaling
nt06274 Thyroid cancer
Type
Variant
Pathway
hsa05216  Thyroid cancer
Disease
H00032  Thyroid cancer
Gene
999  CDH1; cadherin 1
1499  CTNNB1; catenin beta 1
6932  TCF7; transcription factor 7
83439  TCF7L1; transcription factor 7 like 1
6934  TCF7L2; transcription factor 7 like 2
51176  LEF1; lymphoid enhancer binding factor 1
4609  MYC; MYC proto-oncogene, bHLH transcription factor
595  CCND1; cyclin D1
Variant
999v1  CDH1 reduced expression
Reference
  Authors
Kondo T, Ezzat S, Asa SL.
  Title
Pathogenetic mechanisms in thyroid follicular-cell neoplasia.
  Journal
Nat Rev Cancer 6:292-306 (2006)
DOI:10.1038/nrc1836
Reference
  Authors
Rocha AS, Soares P, Seruca R, Maximo V, Matias-Guiu X, Cameselle-Teijeiro J, Sobrinho-Simoes M
  Title
Abnormalities of the E-cadherin/catenin adhesion complex in classical papillary thyroid carcinoma and in its diffuse sclerosing variant.
  Journal
J Pathol 194:358-66 (2001)
DOI:10.1002/path.905
Reference
  Authors
Van Aken E, De Wever O, Correia da Rocha AS, Mareel M
  Title
Defective E-cadherin/catenin complexes in human cancer.
  Journal
Virchows Arch 439:725-51 (2001)
DOI:10.1007/s004280100516

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