KEGG   NETWORK: N00062Help
Entry
N00062                      Network                                

Name
Hedgehog signaling pathway
Definition
SHH -> PTCH1 // SMO -> SUFU // GLI => (GLI1,PTCH,HHIP)
  Expanded
6469 -> 5727 // 6608 -> 51684 // (2735,2736,2737) => (2735,5727,8643,64399)
Class
nt06217 HH signaling
nt06269 Basal cell carcinoma
Type
Reference
Pathway
hsa04340  Hedgehog signaling pathway
Gene
6469  SHH; sonic hedgehog
5727  PTCH1; patched 1
6608  SMO; smoothened, frizzled class receptor
51684  SUFU; SUFU negative regulator of hedgehog signaling
2735  GLI1; GLI family zinc finger 1
2736  GLI2; GLI family zinc finger 2
2737  GLI3; GLI family zinc finger 3
2735  GLI1; GLI family zinc finger 1
5727  PTCH1; patched 1
8643  PTCH2; patched 2
64399  HHIP; hedgehog interacting protein
Reference
  Authors
Briscoe J, Therond PP
  Title
The mechanisms of Hedgehog signalling and its roles in development and disease.
  Journal
Nat Rev Mol Cell Biol 14:416-29 (2013)
DOI:10.1038/nrm3598
Reference
  Authors
Alman BA
  Title
The role of hedgehog signalling in skeletal health and disease.
  Journal
Nat Rev Rheumatol 11:552-60 (2015)
DOI:10.1038/nrrheum.2015.84
Reference
  Authors
Cohen MM Jr.
  Title
The hedgehog signaling network.
  Journal
Am J Med Genet A 123:5-28 (2003)
DOI:10.1002/ajmg.a.20495
Reference
  Authors
Sasai N, Briscoe J
  Title
Primary cilia and graded Sonic Hedgehog signaling.
  Journal
Wiley Interdiscip Rev Dev Biol 1:753-72 (2012)
DOI:10.1002/wdev.43

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