KEGG   NETWORK: N00070Help
Entry
N00070                      Network                                

Name
Mutation-inactivated p16(INK4a) to p16-cell cycle G1/S
Definition
CDKN2A* // (CCND+CDK4/6) -> RB1 // E2F
  Expanded
1029v2 // ((595,894,896)+(1019,1021)) -> 5925 // (1869,1870,1871)
Class
nt06230 Cell cycle G1/S
nt06262 Pancreatic cancer
nt06266 Non-small cell lung cancer
nt06268 Melanoma
nt06276 Chronic myeloid leukemia
Type
Variant
Pathway
hsa05212  Pancreatic cancer
hsa05220  Chronic myeloid leukemia
hsa05218  Melanoma
hsa05223  Non-small cell lung cancer
Disease
H00019  Pancreatic cancer
H00004  Chronic myeloid leukemia
H00038  Melanoma
H00014  Non-small cell lung cancer
Gene
1029  CDKN2A; cyclin dependent kinase inhibitor 2A
595  CCND1; cyclin D1
894  CCND2; cyclin D2
896  CCND3; cyclin D3
1019  CDK4; cyclin dependent kinase 4
1021  CDK6; cyclin dependent kinase 6
5925  RB1; RB transcriptional corepressor 1
1869  E2F1; E2F transcription factor 1
1870  E2F2; E2F transcription factor 2
1871  E2F3; E2F transcription factor 3
Variant
1029v2  CDKN2A mutation
Reference
  Authors
Schmid RM.
  Title
Genetic basis of pancreatic cancer.
  Journal
Best Pract Res Clin Gastroenterol 16:421-33 (2002)
DOI:10.1053/bega.2002.0316
Reference
  Authors
Calabretta B, Perrotti D.
  Title
The biology of CML blast crisis.
  Journal
Blood 103:4010-22 (2004)
DOI:10.1182/blood-2003-12-4111
Reference
  Authors
Miller AJ, Mihm MC Jr.
  Title
Melanoma.
  Journal
N Engl J Med 355:51-65 (2006)
DOI:10.1056/NEJMra052166
Reference
  Authors
Meuwissen R, Berns A.
  Title
Mouse models for human lung cancer.
  Journal
Genes Dev 19:643-64 (2005)
DOI:10.1101/gad.1284505

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