KEGG   NETWORK: N00079Help
Entry
N00079                      Network                                

Name
HIF-1 signaling pathway
Definition
HIF1A -- ARNT => (SLC2A1,VEGFA,TGFB,PDGFB,TGFA)
  Expanded
3091 -- 405 => (6513,7422,7040,7042,7043,5155,7039)
Class
nt06225 HIF-1 signaling
nt06264 Renal cell carcinoma
Type
Reference
Pathway
hsa04066  HIF-1 signaling pathway
Gene
3091  HIF1A; hypoxia inducible factor 1 alpha subunit
405  ARNT; aryl hydrocarbon receptor nuclear translocator
6513  SLC2A1; solute carrier family 2 member 1
7422  VEGFA; vascular endothelial growth factor A
7040  TGFB1; transforming growth factor beta 1
7042  TGFB2; transforming growth factor beta 2
7043  TGFB3; transforming growth factor beta 3
5155  PDGFB; platelet derived growth factor subunit B
7039  TGFA; transforming growth factor alpha
Reference
  Authors
Greer SN, Metcalf JL, Wang Y, Ohh M
  Title
The updated biology of hypoxia-inducible factor.
  Journal
EMBO J 31:2448-60 (2012)
DOI:10.1038/emboj.2012.125
Reference
  Authors
Semenza GL
  Title
Regulation of oxygen homeostasis by hypoxia-inducible factor 1.
  Journal
Physiology (Bethesda) 24:97-106 (2009)
DOI:10.1152/physiol.00045.2008
Reference
  Authors
Lee JW, Bae SH, Jeong JW, Kim SH, Kim KW
  Title
Hypoxia-inducible factor (HIF-1)alpha: its protein stability and biological functions.
  Journal
Exp Mol Med 36:1-12 (2004)
DOI:10.1038/emm.2004.1

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