KEGG   NETWORK: N00080
Entry
N00080                      Network                                

Name
Loss of VHL to HIF-1 signaling pathway
Definition
(VHL*+RBX1+ELOC+ELOB+CUL2) // HIF1A -- ARNT => (SLC2A1,VEGFA,TGFB,PDGFB,TGFA)
  Expanded
(7428v1+9978+6921+6923+8453) // 3091 -- 405 => (6513,7422,7040,7042,7043,5155,7039)
Class
nt06225 HIF-1 signaling
nt06264 Renal cell carcinoma
Type
Variant
Pathway
hsa05211  Renal cell carcinoma
Disease
H00021  Renal cell carcinoma
Gene
7428  VHL; von Hippel-Lindau tumor suppressor
9978  RBX1; ring-box 1
6921  ELOC; elongin C
6923  ELOB; elongin B
8453  CUL2; cullin 2
3091  HIF1A; hypoxia inducible factor 1 alpha subunit
405  ARNT; aryl hydrocarbon receptor nuclear translocator
6513  SLC2A1; solute carrier family 2 member 1
7422  VEGFA; vascular endothelial growth factor A
7040  TGFB1; transforming growth factor beta 1
7042  TGFB2; transforming growth factor beta 2
7043  TGFB3; transforming growth factor beta 3
5155  PDGFB; platelet derived growth factor subunit B
7039  TGFA; transforming growth factor alpha
Variant
7428v1 (VHL*)  VHL loss
Reference
  Authors
Cohen HT, McGovern FJ.
  Title
Renal-cell carcinoma.
  Journal
N Engl J Med 353:2477-90 (2005)
DOI:10.1056/NEJMra043172
Reference
  Authors
Linehan WM, Zbar B.
  Title
Focus on kidney cancer.
  Journal
Cancer Cell 6:223-8 (2004)
DOI:10.1016/j.ccr.2004.09.006
Reference
  Authors
Pavlovich CP, Schmidt LS.
  Title
Searching for the hereditary causes of renal-cell carcinoma.
  Journal
Nat Rev Cancer 4:381-93 (2004)
DOI:10.1038/nrc1364

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