KEGG   NETWORK: N00084Help
Entry
N00084                      Network                                

Name
Amplified AR to androgen receptor signaling pathway
Definition
(T,DHT) -> AR* => KLK3
  Expanded
(C00535,C03917) -> 367v1 => 354
Class
nt06227 NR signaling
nt06272 Prostate cancer
Type
Variant
Pathway
hsa05215  Prostate cancer
Disease
H00024  Prostate cancer
Gene
367  AR; androgen receptor
354  KLK3; kallikrein related peptidase 3
Variant
367v1  AR amplification
Metabolite
C00535  Testosterone
C03917  Dihydrotestosterone
Reference
  Authors
Nelson WG, De Marzo AM, Isaacs WB.
  Title
Prostate cancer.
  Journal
N Engl J Med 349:366-81 (2003)
DOI:10.1056/NEJMra021562
Reference
PMID:8145761
  Authors
Culig Z, Hobisch A, Cronauer MV, Cato AC, Hittmair A, Radmayr C, Eberle J, Bartsch G, Klocker H
  Title
Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone.
  Journal
Mol Endocrinol 7:1541-50 (1993)
DOI:10.1210/mend.7.12.8145761
Reference
  Authors
Pienta KJ, Bradley D.
  Title
Mechanisms underlying the development of androgen-independent prostate cancer.
  Journal
Clin Cancer Res 12:1665-71 (2006)
DOI:10.1158/1078-0432.CCR-06-0067
Reference
  Authors
Feldman BJ, Feldman D.
  Title
The development of androgen-independent prostate cancer.
  Journal
Nat Rev Cancer 1:34-45 (2001)
DOI:10.1038/35094009
Reference
PMID:9422516
  Authors
Koivisto P, Kolmer M, Visakorpi T, Kallioniemi OP.
  Title
Androgen receptor gene and hormonal therapy failure of prostate cancer.
  Journal
Am J Pathol 152:1-9 (1998)

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