KEGG   NETWORK: N00096Help
Entry
N00096                      Network                                

Name
EGF-EGFR-RAS-RASSF1 signaling pathway
Definition
EGF -> EGFR -> GRB2 -> SOS -> RAS -> (RASSF1+RASSF5) -> STK4
  Expanded
1950 -> 1956 -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (11186+83593) -> 6789
Class
nt06213 Other RAS signaling
nt06266 Non-small cell lung cancer
Type
Reference
Pathway
hsa04014  Ras signaling pathway
Gene
1950  EGF; epidermal growth factor
1956  EGFR; epidermal growth factor receptor
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
11186  RASSF1; Ras association domain family member 1
83593  RASSF5; Ras association domain family member 5
6789  STK4; serine/threonine kinase 4
Reference
  Authors
Donninger H, Vos MD, Clark GJ
  Title
The RASSF1A tumor suppressor.
  Journal
J Cell Sci 120:3163-72 (2007)
DOI:10.1242/jcs.010389
Reference
  Authors
Cox AD, Der CJ
  Title
The dark side of Ras: regulation of apoptosis.
  Journal
Oncogene 22:8999-9006 (2003)
DOI:10.1038/sj.onc.1207111
Reference
  Authors
Wong CM, Ng IO
  Title
Molecular pathogenesis of hepatocellular carcinoma.
  Journal
Liver Int 28:160-74 (2008)
DOI:10.1111/j.1478-3231.2007.01637.x

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