KEGG   NETWORK: N00097Help
Entry
N00097                      Network                                

Name
Loss of RASSF1 to RAS-RASSF1 signaling pathway
Definition
RAS // (RASSF1*+RASSF5) // STK4
  Expanded
(3265,3845,4893) // (11186v1+83593) // 6789
Class
nt06213 Other RAS signaling
nt06266 Non-small cell lung cancer
Type
Variant
Pathway
hsa05223  Non-small cell lung cancer
Disease
H00014  Non-small cell lung cancer
Gene
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
11186  RASSF1; Ras association domain family member 1
83593  RASSF5; Ras association domain family member 5
6789  STK4; serine/threonine kinase 4
Variant
11186v1  RASSF1 loss
Reference
  Authors
Aviel-Ronen S, Blackhall FH, Shepherd FA, Tsao MS.
  Title
K-ras mutations in non-small-cell lung carcinoma: a review.
  Journal
Clin Lung Cancer 8:30-8 (2006)
DOI:10.3816/CLC.2006.n.030
Reference
  Authors
Pfeifer GP, Dammann R.
  Title
Methylation of the tumor suppressor gene RASSF1A in human tumors.
  Journal
Biochemistry (Mosc) 70:576-83 (2005)

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