KEGG   NETWORK: N00102Help
Entry
N00102                      Network                                

Name
Loss of DCC to DCC-apoptotic pathway
Definition
CASP3 // DCC* // (CASP9+APPL1)
  Expanded
836 // 1630v1 // (842+26060)
Class
nt06231 Apoptosis
nt06260 Colorectal cancer
Type
Variant
Pathway
hsa05210  Colorectal cancer
Disease
H00020  Colorectal cancer
Gene
836  CASP3; caspase 3
1630  DCC; DCC netrin 1 receptor
842  CASP9; caspase 9
26060  APPL1; adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
Variant
1630v1  DCC loss
Reference
  Authors
Arakawa H.
  Title
Netrin-1 and its receptors in tumorigenesis.
  Journal
Nat Rev Cancer 4:978-87 (2004)
DOI:10.1038/nrc1504
Reference
  Authors
Ko SY, Dass CR, Nurgali K
  Title
Netrin-1 in the developing enteric nervous system and colorectal cancer.
  Journal
Trends Mol Med 18:544-54 (2012)
DOI:10.1016/j.molmed.2012.07.001

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