KEGG   NETWORK: N00112Help
Entry
N00112                      Network                                

Name
AML1-ETO fusion to PU.1-mediated transcription
Definition
AML1-ETO -| SPI1 => (CD14,ITGAM,FCGR1A)
  Expanded
861v2 -| 6688 => (929,3684,2209)
Class
nt06240 Transcription
nt06275 Acute myeloid leukemia
Type
Variant
Pathway
hsa05221  Acute myeloid leukemia
hsa05202  Transcriptional misregulation in cancer
Disease
H00003  Acute myeloid leukemia
Gene
861  RUNX1; runt related transcription factor 1
6688  SPI1; Spi-1 proto-oncogene
929  CD14; CD14 molecule
3684  ITGAM; integrin subunit alpha M
2209  FCGR1A; Fc fragment of IgG receptor Ia
Variant
861v2  AML1-ETO fusion
Reference
  Authors
Vangala RK, Heiss-Neumann MS, Rangatia JS, Singh SM, Schoch C, Tenen DG, Hiddemann W, Behre G
  Title
The myeloid master regulator transcription factor PU.1 is inactivated by AML1-ETO in t(8;21) myeloid leukemia.
  Journal
Blood 101:270-7 (2003)
DOI:10.1182/blood-2002-04-1288

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