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Entry
N00115                      Network                                

Name
Mutation-inactivated TP53 to transcription
Definition
TP53* // (CDKN1A,GADD45,BAX,BAK1,DDB2,POLK)
  Expanded
7157v1 // (1026,1647,4616,10912,581,578,1643,51426)
Class
nt06240 Transcription
nt06260 Colorectal cancer
nt06261 Gastric cancer
nt06262 Pancreatic cancer
nt06263 Hepatocellular carcinoma
nt06265 Bladder cancer
nt06266 Non-small cell lung cancer
nt06267 Small cell lung cancer
nt06268 Melanoma
nt06269 Basal cell carcinoma
nt06270 Breast cancer
nt06271 Endometrial cancer
nt06273 Glioma
nt06274 Thyroid cancer
nt06276 Chronic myeloid leukemia
Type
Variant
Pathway
hsa05210  Colorectal cancer
hsa05212  Pancreatic cancer
hsa05225  Hepatocellular carcinoma
hsa05226  Gastric cancer
hsa05214  Glioma
hsa05220  Chronic myeloid leukemia
hsa05217  Basal cell carcinoma
hsa05218  Melanoma
hsa05216  Thyroid cancer
hsa05219  Bladder cancer
hsa05213  Endometrial cancer
hsa05224  Breast cancer
hsa05222  Small cell lung cancer
hsa05223  Non-small cell lung cancer
hsa05202  Transcriptional misregulation in cancer
Disease
H00020  Colorectal cancer
H00019  Pancreatic cancer
H00048  Hepatocellular carcinoma
H00018  Gastric cancer
H00042  Glioma
H00004  Chronic myeloid leukemia
H00039  Basal cell carcinoma
H00038  Melanoma
H00032  Thyroid cancer
H00022  Bladder cancer
H00026  Endometrial cancer
H00031  Breast cancer
H00013  Small cell lung cancer
H00014  Non-small cell lung cancer
Gene
7157  TP53; tumor protein p53
1026  CDKN1A; cyclin dependent kinase inhibitor 1A
1647  GADD45A; growth arrest and DNA damage inducible alpha
4616  GADD45B; growth arrest and DNA damage inducible beta
10912  GADD45G; growth arrest and DNA damage inducible gamma
581  BAX; BCL2 associated X, apoptosis regulator
578  BAK1; BCL2 antagonist/killer 1
1643  DDB2; damage specific DNA binding protein 2
51426  POLK; DNA polymerase kappa
Variant
7157v1  TP53 mutation
Reference
PMID:9738588
  Authors
Kirsch DG, Kastan MB
  Title
Tumor-suppressor p53: implications for tumor development and prognosis.
  Journal
J Clin Oncol 16:3158-68 (1998)
DOI:10.1200/JCO.1998.16.9.3158
Reference
  Authors
Fridman JS, Lowe SW
  Title
Control of apoptosis by p53.
  Journal
Oncogene 22:9030-40 (2003)
DOI:10.1038/sj.onc.1207116
Reference
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
  Authors
Reed SM, Quelle DE
  Title
p53 Acetylation: Regulation and Consequences.
  Journal
Cancers (Basel) 7:30-69 (2014)
DOI:10.3390/cancers7010030

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