Entry |
|
Name |
TEL-AML1 fusion to transcriptional repression
|
Definition |
TEL-AML1 == (HDAC+SIN3A+NCOR1) =| (IL3,CSF2,MPO,DEFA3,ELANE,GZMB) |
Expanded |
861v4 == ((3065,3066)+25942+9611) =| (3562,1437,4353,1668,1991,3002) |
Class |
|
Type |
Variant
|
Disease |
H00001 | B-cell acute lymphoblastic leukemia |
|
Gene |
861 | RUNX1; runt related transcription factor 1 |
3065 | HDAC1; histone deacetylase 1 |
3066 | HDAC2; histone deacetylase 2 |
25942 | SIN3A; SIN3 transcription regulator family member A |
9611 | NCOR1; nuclear receptor corepressor 1 |
1437 | CSF2; colony stimulating factor 2 |
4353 | MPO; myeloperoxidase |
1668 | DEFA3; defensin alpha 3 |
1991 | ELANE; elastase, neutrophil expressed |
|
Variant |
861v4 (TEL-AML1) TEL-AML1 fusion
|
Reference |
|
Authors |
Zelent A, Greaves M, Enver T |
Title |
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia. |
Journal |
|
Reference |
|
Authors |
Sawinska M, Ladon D |
Title |
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia. |
Journal |
|
Reference |
|
Authors |
Gunji H, Waga K, Nakamura F, Maki K, Sasaki K, Nakamura Y, Mitani K |
Title |
TEL/AML1 shows dominant-negative effects over TEL as well as AML1. |
Journal |
|
Reference |
|
Authors |
Lutterbach B, Hiebert SW |
Title |
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation. |
Journal |
|