KEGG   NETWORK: N00118Help
Entry
N00118                      Network                                

Name
TEL-AML1 fusion to transcriptional repression
Definition
TEL-AML1 -- (HDAC+SIN3A+NCOR1) =| (IL3,CSF2,MPO,DEFA3,ELANE,GZMB)
  Expanded
861v4 -- ((3065,3066)+25942+9611) =| (3562,1437,4353,1668,1991,3002)
Class
nt06240 Transcription
Type
Variant
Pathway
hsa05202  Transcriptional misregulation in cancer
Disease
H00001  B-cell acute lymphoblastic leukemia
Gene
861  RUNX1; runt related transcription factor 1
3065  HDAC1; histone deacetylase 1
3066  HDAC2; histone deacetylase 2
25942  SIN3A; SIN3 transcription regulator family member A
9611  NCOR1; nuclear receptor corepressor 1
3562  IL3; interleukin 3
1437  CSF2; colony stimulating factor 2
4353  MPO; myeloperoxidase
1668  DEFA3; defensin alpha 3
1991  ELANE; elastase, neutrophil expressed
3002  GZMB; granzyme B
Variant
861v4  TEL-AML1 fusion
Reference
  Authors
Zelent A, Greaves M, Enver T
  Title
Role of the TEL-AML1 fusion gene in the molecular pathogenesis of childhood acute lymphoblastic leukaemia.
  Journal
Oncogene 23:4275-83 (2004)
DOI:10.1038/sj.onc.1207672
Reference
  Authors
Sawinska M, Ladon D
  Title
Mechanism, detection and clinical significance of the reciprocal translocation t(12;21)(p12;q22) in the children suffering from acute lymphoblastic leukaemia.
  Journal
Leuk Res 28:35-42 (2004)
DOI:10.1016/S0145-2126(03)00160-7
Reference
  Authors
Gunji H, Waga K, Nakamura F, Maki K, Sasaki K, Nakamura Y, Mitani K
  Title
TEL/AML1 shows dominant-negative effects over TEL as well as AML1.
  Journal
Biochem Biophys Res Commun 322:623-30 (2004)
DOI:10.1016/j.bbrc.2004.07.169
Reference
  Authors
Lutterbach B, Hiebert SW
  Title
Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation.
  Journal
Gene 245:223-35 (2000)
DOI:10.1016/S0378-1119(00)00014-7

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