Entry |
|
Name |
Amplified MYCN to transcriptional repression
|
Definition |
MYCN* == MAX == (SP1+ZBTB17) => (NTRK1,NGFR) |
Expanded |
4613v1 == 4149 == (6667+7709) => (4914,4804) |
Class |
|
Type |
Variant
|
Disease |
|
Gene |
4613 | MYCN; MYCN proto-oncogene, bHLH transcription factor |
4149 | MAX; MYC associated factor X |
6667 | SP1; Sp1 transcription factor |
7709 | ZBTB17; zinc finger and BTB domain containing 17 |
4914 | NTRK1; neurotrophic receptor tyrosine kinase 1 |
4804 | NGFR; nerve growth factor receptor |
|
Variant |
4613v1 (MYCN*) MYCN amplification
|
Reference |
|
Authors |
Westermark UK, Wilhelm M, Frenzel A, Henriksson MA |
Title |
The MYCN oncogene and differentiation in neuroblastoma. |
Journal |
|
Reference |
|
Authors |
Iraci N, Diolaiti D, Papa A, Porro A, Valli E, Gherardi S, Herold S, Eilers M, Bernardoni R, Della Valle G, Perini G |
Title |
A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF. |
Journal |
|